My Heart vs. the Real World: Children with Heart Disease, In Photographs & Interviews

“Several of Gerber’s photographs are haunting depictions of the children in their toughest moments — in immense pain just after surgery, for example. But because Gerber has shared the children’s experiences — he was born with bradycardia and has a pacemaker — the photographs feel intimate rather than voyeuristic...The way Gerber manages to convey a complex whirl of emotions and qualities, such as determination, vulnerability, and sorrow, in a single frame is partly due to this shared intimacy with his subjects, but it is also down to his innate skill for portraiture.”

The Cardiovascular System (CSH Symposia on Quantitative Biology LXVII)

This volume presents a remarkable survey of current progress in understanding the genetic basis of cardiovascular function, development, and disease. Sections are devoted to angiogenesis, cardiogenesis, homeostasis, development, vascular biology, and cardiovascular repair and therapy. The book is an essential source of ideas, discoveries, and references for clinical scientists and physicians interested in basic cardiac biology, hypertension, atherosclerosis, coronary artery disease, and heart failure.

The Strongest Boy in the World: How Genetic Information is Reshaping Our Lives, Updated and Expanded Edition

“For the geneticist, Reilly presents a balanced, positive view of ethical and social issues in genetics, and an entertaining background in history, geography and economics, and the way these fields interface with modern genetics and genomics. I’ve often tried to convince my colleagues across campus that genetics should be a part of every undergraduate’s education. No book makes this case more clearly than The Strongest Boy in the World.”

Statistics at the Bench: A Step-by-Step Handbook for Biologists

This is a handbook for working scientists that provides a simple refresher for those who have forgotten what they once knew, and an overview for those wishing to use more quantitative reasoning in their research. Statistical methods, as well as guidelines for the interpretation of results, are explained using simple examples. Throughout the book, examples are accompanied by detailed Excel commands for easy reference.

First web availability of the renowned book series

The first volume of this series, published in 1970, dealt with the lactose operon. Beckwith and Zipser, the editors of that book, began their preface as follows: “ Much of the development of molecular biology has depended on the study of certain key biological systems. The lactose operon of E. coli is clearly one of these systems.” Clearly, phage λ is another.

Like that first book, this one arose out of a conference proposed by Jim Watson. The conference on λ was arranged by Dale Kaiser and Allan Campbell and was held at Cold Spring Harbor in September 1970.

Watson contributed to this book in another way. For years the rumor had gone about that “Jim Watson is thinking of writing a book about λ.” The rumor preserved the subject for the present authors. Read More.

The CSH Monograph Archive offers the complete collection of scholarly monographs published by Cold Spring Harbor Laboratory Press from 1970 to 2009. The archive’s 59 full-text volumes provide the life science community with definitive reviews of progress in areas of molecular, cell, and developmental biology, genetics, evolutionary biology, neuroscience, cancer biology, and molecular pathology. Each text is written and commissioned by foremost researchers in their particular discipline.

It is available online as a complete collection for one-time purchase (with perpetual access) or on pay-per-view basis by book chapter.

Live Cell Imaging: A Laboratory Manual, Second Edition

The second edition of Live Cell Imaging: A Laboratory Manual expands upon and extends the collection of established and evolving methods for studying dynamic changes in living cells and organisms presented in the well-known first edition. There are 16 new chapters and the 21 updated chapters in this new edition. The movies on the accompanying website — www.cshprotocols.org/livecellimaging — display the power of recent advances in technical imaging of living cells.

Mouse Hematology: A Laboratory Manual

Along with a short laboratory manual featuring detailed protocols, Mouse Hematology includes a DVD of short video demonstrations of the techniques and a poster of blood cell types for easy identification at the microscope. These integrated resources can save valuable time essential to the design, development, and interpretation of experiments involving peripheral blood and bone marrow samples.

A new type of online review journal

• Spanning the complete spectrum of the molecular life sciences

• Article collections that build month by month

• Written and commissioned by experts in each field

Read these essential papers in this month’s issue:

Alan Hall and Giovanna Lalli discuss GTPase functions in axon guidance.
The establishment of precise neuronal cell morphology provides the foundation for all aspects of neurobiology. During development, axons emerge from cell bodies after an initial polarization stage, elongate, and navigate towards target regions guided by a range of environmental cues. Read the full text

Organizing bacterial DNA — Esteban Toro and Lucy Shapiro on nucleoid positioning and inheritance.
Bacterial chromosomes are generally _1000 times longer than the cells inwhich they reside, and concurrent replication, segregation, and transcription/translation of this crowded mass of DNA poses a challenging organizational problem. Read the full text

Julian Heuberger and Walter Birchmeier examine interplay between cell adhesion and Wnt signaling.
The epithelial–mesenchymal transition is essential in both embryonic development and the progression of carcinomas. Wnt signaling and cadherin-mediated adhesion have been implicated in both processes; clarifying their role will depend on linking them to rearrangements of cellular structure and behavior. Read the full text

Visit here for this month’s complete table of contents and to learn more.