|
Save 15% on Antibodies, A Laboratory Manual, Second Edition for a limited time only. Discount applies to direct purchase by individual U.S. and Canada customers only.
(Note: You do not need to be a member of our Discount Program to receive this discount; however, if you are a member or if you register on our site to become a member of our Discount Program, you will receive an additional 10% discount.)
|
Not to be combined with any other discounts. Offer expires June 30th, 2013. Free shipping offer applies to direct website purchases by individual U.S. and Canada customers only and only to the titles listed.
|
|
|
Click here for more sale titles at 80% off
|
|
|
Mammalian Development: Networks, Switches, and Morphogenetic Processes
This book provides a contemporary overview of the conceptual framework of molecular and cellular mechanisms of mammalian development, and a glimpse into future directions in mammalian developmental biology and its relevance to cellular and tissue therapy. Major areas of focus are transcriptional and epigenetic switches and the activity of genetic networks in cell differentiation, the role of signaling pathways, and tissue modeling and organ formation. Another major focus is on the translation of basic knowledge of developmental processes into stem cell biology, directed differentiation of pluripotent or lineage-biased progenitors, and the potential for regenerative medicine.
|
Immune Tolerance
Written and edited by experts in the field, this work reviews how self-tolerant T- and B-cell populations are produced. The contributors discuss the elimination of autoreactive lymphocytes during their development in the thymus and bone marrow, the suppression of autoreactive cells by regulatory T cells in the periphery, and intrinsic mechanisms that produce clonal anergy. The roles of dendritic cells in antigen presentation and mechanisms that prevent autoreactivity in natural killer cells are also covered. Including discussions of autoimmune diseases, their genetic bases, and therapeutic strategies, this volume is a valuable reference for all immunologists and clinicians wishing to understand or develop treatments for autoimmune diseases.
|
Hemoglobin and Its Diseases
This collection from Cold Spring Harbor Perspectives in Medicine covers all aspects of hemoglobin and its diseases. Contributors examine the structure, expression, and evolution of the globin genes, the assembly of globin subunits into functional forms of hemoglobin, and the numerous variants that result from genetic alterations. The pathophysiological consequences of hemoglobin disorders (e.g., ineffective erythropoiesis and aberrant iron homeostasis), their clinical manifestations, and epidemiological trends are also described. It includes discussions of management and treatment strategies for hemoglobin disorders, such as transfusions, iron-chelating agents, gene therapy, and stem cell transplantation. It is an indispensable reference for biochemists, geneticists, cell and developmental biologists, physiologists, and all who are interested in reducing the medical burden of these common genetic diseases.
|
The Biology of Plants
(Cold Spring Harbor Symposia on Quantitative Biology LXXVII)
During the past several decades plant biology has been revolutionized first by molecular biology and then by the genomic era. With the genomes of more than thirty plant species now available and many more planned in the near future, the impact on our understanding of plant evolution and biology continues to grow. Our increased ability to engineer plant species to a variety of ends may provide novel solutions to ensure adequate and reliable food production and renewable energy even as climate change impacts our environment. The decision to focus the 2012 Symposium on plant science reflects the enormous research progress achieved in recent years, and is intended to provide a broad synthesis of the current state of the field, setting the stage for future discoveries and application. This is the first Symposium in this historic series focused exclusively on the botanical sciences.
|
Cystic Fibrosis: A Trilogy of Biochemistry, Physiology, and Therapy
This volume from Cold Spring Harbor Perspectives in Medicine examines the numerous mutations in the CFTR gene and their phenotypic consequences, the function and regulation of the CFTR channel, and the role of CFTR in the lung airway epithelium, intestine, and pancreas. The physical and biochemical properties of mucus, and its overproduction during cystic fibrosis, are also discussed. The book also covers therapeutic strategies for treating cystic fibrosis, so it will be an essential reference for molecular and cellular biologists, physiologists, and other scientists pursuing the biological basis and treatment of the disease.
|
|
 |
|
|
| Top Sellers This Month |
|
Visit the Sale Shelf
|
|
|
|
 |
|
|
Hundreds of important advances in biology were announced, debated, and distilled at the Cold Spring Harbor Symposia.
These meetings, held each year on the tranquil grounds of one of the world’s leading research institutes, have been notable events in biomedical research since 1933.
Now this essential archive, dating from 1933 to 2003, is available online for a one-time fee.
|
|
|
A new type of online review journal
• Spanning the complete spectrum of the molecular life sciences
• Article collections that build month by month
• Written and commissioned by experts in each field
Read these essential papers in this month’s issue:
Going the distance: Thomas Schwarz on mitochondrial trafficking in neurons.
Neurons, perhaps more than any other cell type, depend on mitochondrial trafficking for their survival. Recent studies have elucidated a motor/adaptor complex on the mitochondrial surface that is shared between neurons and other animal cells. In addition to kinesin and dynein, this complex contains the proteins Miro (also called RhoT1/2) and milton (also called TRAK1/2) and is responsible for much, although not necessarily all, mitochondrial movement.
Read the full text.
Sally Kornbluth reviews caspase regulation in apoptosis and other cellular processes.
Caspases are the primary drivers of apoptotic cell death, cleaving cellular proteins that are critical for dismantling the dying cell. Initially translated as inactive zymogenic precursors, caspases are activated in response to a variety of cell death stimuli. In addition to factors required for their direct activation (e.g., dimerizing adaptor proteins in the case of initiator caspases that lie at the apex of apoptotic signaling cascades), caspases are regulated by a variety of cellular factors in a myriad of physiological and pathological settings.
Read the full text.
Alexander Sorkin describes how endocytosis controls signaling by receptor tyrosine kinases.
Endocytosis is the major regulator of signaling from receptor tyrosine kinases (RTKs). The canonical model of RTK endocytosis involves rapid internalization of an RTK activated by ligand binding at the cell surface and subsequent sorting of internalized ligand-RTK complexes to lysosomes for degradation.
Read the full text.
Visit here for this month’s complete table of contents and to learn more.
|
The Complete, Renowned Book Series Now Online!
From the Preface of Volume I: The Molecular and Cellular Biology of the Yeast Saccharomyces: Genome Dynamics, Protein Synthesis, and Energetics:
In all eukaryotic cells, each fundamental process-cycle progression and its control, protein secretion and targeting, transcription and its regulation, mRNA processing, and DNA replication-accomplished by essentially identical cellular machinery composed of essentially identical protein components. This conservation of function has catapulted the yeasts Saccharomyces cerevisiae and Schizosaccharomyces pombe from parochial backwaters to the forefront of experimental molecular biology: What is true for a yeast is true for an elephant, and in experiments you can get the answer a lot faster from a yeast.
The CSH Monograph Archive offers the complete collection of scholarly monographs published by Cold Spring Harbor Laboratory Press from 1970 to 2009. The archive’s 59
full-text volumes provide the life science community with definitive reviews of progress in areas of molecular, cell, and developmental biology, genetics, evolutionary biology, neuroscience,
cancer biology, and molecular pathology. Each text is written and commissioned by foremost researchers in their particular discipline.
It is available online as a complete collection for one-time purchase (with perpetual access) or on pay-per-view basis by book chapter.
|
|
Checkout/View Cart
