Transcriptome characterization by RNA sequencing identifies a major molecular and clinical subdivision in chronic lymphocytic leukemia.
Pedro G. Ferreira, Pedro Jares, Daniel Rico, Gonzalo Gómez-López, Alejandra Martínez-Trillos, Neus Villamor, Simone Ecker, Abel González-Pérez, David G. Knowles, Jean Monlong, Rory Johnson, Victor Quesada, Sarah Djebali, Panagiotis Papasaikas, Mónica López-Guerra, Dolors Colomer, Cristina Royo, Maite Cazorla, Magda Pinyol, Guillem Clot, Marta Aymerich, Maria Rozman, Marta Kulis, David Tamborero, Anaïs Gouin, Julie Blanc, Marta Gut, Ivo Gut, Xose S. Puente, David G. Pisano, José Ignacio Martin-Subero, Nuria López-Bigas, Armando López-Guillermo, Alfonso Valencia, Carlos López-Otín, Elías Campo, and Roderic Guigó
Vol. 24 (2) 212226.
This month Genome Research highlights cutting edge research in
cancer genomics. In one study, featured on ScienceDaily and
GenomeWeb, integration of human papilloma virus (HPV) increased genomic instability of the host genome
in cervical, head and neck cancers. A molecular and clinical subdivision in chronic lymphocytic leukemia (CLL), which may aid in predicting time to treatment, is
reported in another study. Also in this issue, extensive intra-tumor heterogeneity in ovarian cancer genomes is identified and may contribute to high rates of cancer recurrence.
These studies were profiled on GenomeWebs The Daily Scan, and can be found, along with the other cancer genomics studies
from this issue, here.