© 2008 • 841 pp., illus., index
(Published and /or distributed in conjunction with Benjamin Cummings)
Hardcover • $160.40 • ISBN  978-080539592-1

Co-published with Benjamin Cummings. Requests for examination copies for textbook adoptions should be sent to Benjamin Cummings at www.aw-bc.com/watson/.

This sixth edition of James D. Watson’s classic textbook Molecular Biology of the Gene has been thoroughly revised and updated. Accessible to anyone interested in molecular biology and genetics, the book provides a historical basis for the field, concise descriptions of fundamental chemical concepts, a comprehensive survey of genome maintenance and expression, and a discussion of standard techniques and model organisms commonly used in molecular biology studies. It includes all new chapters on the regulatory RNAs and genomics and systems biology. The book has an accompanying Web site (www.aw-bc.com/watson/), which contains interactive tutorials, animations, and critical–thinking exercises designed to help students explore and visualize complex concepts.

PART 1: CHEMISTRY AND GENETICS

1. The Mendelian View of the World

2. Nucleic Acids Convey Genetic Information

3. The Importance of Weak Chemical Interactions

4. The Importance of High-Energy Bonds

5. Weak and Strong Bonds Determine Macromolecular Structure

PART 2:  MAINTENANCE OF THE GENOME

6. The Structures of DNA and RNA

7. Genome Structure, Chromatin, and the Nucleosome

8. The Replication of DNA

9. The Mutability and Repair of DNA

10. Homologous Recombination at the Molecular Level

11. Site-specific Recombination and Transposition of DNA

PART 3: EXPRESSION OF THE GENOME

12. Mechanisms of Transcription

13. RNA Splicing

14. Translation

15. The Genetic Code

PART 4: REGULATION

16. Transcriptional Regulation in Prokaryotes

17. Transcriptional Regulation in Eukaryotes

18. Regulatory RNAs

19. Gene Regulation in Development and Evolution

20. Genome Analysis and Systems Biology

PART 5: METHODS

21. Techniques of Molecular Biology

22. Model Organisms

INDEX