© 2004 • 732 pp., illus., index
(Published and /or distributed in conjunction with Benjamin Cummings)
Hardcover • $129 $64.50 • ISBN  978-080534635-0
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This book is co–published with Benjamin Cummings. Requests for textbook examination copies, orders for course adoptions, and ALL individual orders outside of the U.S. should be sent to:

Benjamin Cummings

Pearson Education

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San Francisco, CA 94111

www.aw.com/bc

The first edition of Jim Watson's classic textbook Molecular Biology of the Gene appeared in 1965. This new edition, written with five new authors, has been brought fully up to date, and incorporates insights very recently derived from genome sequencing in a variety of organisms. The book is an authoritative and comprehensive survey of the fundamentals of molecular biology, from basic mechanisms to the elaborate role of gene regulation in embryonic development and evolution. Although updated, the twenty–one chapters of the new edition retain the distinctive and celebrated features of the original work, including introductory chapters on the history of genetics and molecular biology and an emphasis throughout on the chemical underpinnings of molecular biology. The new team of authors brings to this edition award–winning teaching experience and outstanding research achievements. By revealing the intellectual framework and experimental approaches that made new discoveries in the field possible, the new edition highlights the significance of the molecular approach for all of biology.

  “The coverage of the key topics within each [part] is comprehensive and beautifully illustrated with numerous figures that are also available in the accompanying CD, a very useful feature that will provide key resources for both teachers and students....There is no doubt that this is an excellent text book; mature, beautifully discussed and illustrated.”
      —Nature Cell Biology

PART 1: Chemistry and Genetics

Chapter 1: The Mendelian View of the World

Chapter 2: Nucleic Acids Convey Genetic Information

Chapter 3: The Importance of Weak Chemical Interactions

Chapter 4: The Importance of High–Energy Bonds

Chapter 5: Weak and Strong Bonds Determine Macromolecular Structure

PART 2: Maintenance of the Genome

Chapter 6: The Structures of DNA and RNA

Chapter 7: Chromosomes, Chromatin, and the Nucleosome

Chapter 8: The Replication of DNA

Chapter 9: The Mutability and Repair of DNA

Chapter 10: Homologous Recombination at the Molecular Level

Chapter 11: Site–Specific Recombination and Transposition of DNA

PART 3: Expression of the Genome

Chapter 12: Mechanisms of Transcription

Chapter 13: RNA Splicing

Chapter 14: Translation

Chapter 15: The Genetic Code

PART 4: Regulation

Chapter 16: Gene Regulation in Prokaryotes

Chapter 17: Gene Regulation in Eukaryotes

Chapter 18: Gene Regulation during Development

Chapter 19: Comparative Genomics and the Evolution of Animal Diversity

PART 5: Methods

Chapter 20: Techniques of Molecular Biology

Chapter 21: Model Organisms

Index