© 2011 • 422 pp., illus., index
(Paperback edition does not include online access)
Paperback • $129 • ISBN  978-1-936113-57-6

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This volume is based on presentations by world-renowned investigators who gathered at the 76th Cold Spring Harbor Symposium on Quantitative Biology. It reviews the latest advances in our understanding of metabolism and disease, including research on fat, exercise and rhythms; insulin resistance and sensitivity; lifespan, aging and cancer; regulation and dysregulation of metabolism; signaling and gene regulation; environment and sensing; metabolic reprogramming; clocks and intermediary metabolism; metabolism and cancer; and autophagy, timing and small RNAs.

Symposium Participants

Foreword

 

Introduction

 

Bioenergetic Origins of Complexity and Disease

D.C. Wallace

Nuclear Receptors and AMPK: Resetting Metabolism

W. Fan, M. Downes, A. Atkins, R. Yu, and R.M. Evans

Rethinking the Regulation of Cellular Metabolism

C.B. Thompson

 

Clocks and Rhythms

 

The Time of Metabolism: NAD⁺, SIRT1, and the Circadian Clock

M.M. Bellet, R. Orozco-Solis, S. Sahar, K. Eckel-Mahan, and P. Sassone-Corsi

The Mammalian Circadian Timing System: Synchronization of Peripheral Clocks

C. Saini, D.M. Suter, A. Liani, P. Gos, and U. Schibler

Circadian Epigenomic Remodeling and Hepatic Lipogenesis: Lessons from HDAC3

Z. Sun, D. Feng, L.J. Everett, A. Bugge, and M.A. Lazar

Estrogen-Related Receptor α, the Molecular Clock, and Transcriptional Control of Metabolic Outputs

V. Giguère, C.R. Dufour, L.J. Eichner, G. Deblois, and N. Cermakian

Circadian Clocks in Fuel Harvesting and Energy Homeostasis

K.M Ramsey and J. Bass

 

Life Span and Aging

 

Gamete Formation Resets the Aging Clock in Yeast

E. Ünal and A. Amon

Sirtuins, Aging, and Metabolism

L. Guarente

The Heat Shock Response: Systems Biology of Proteotoxic Stress in Aging and Disease

R.I. Morimoto

Skeletal Muscle Stem Cells: Effects of Aging and Metabolism on Muscle Regenerative Function

Y.C. Jang, M. Sinha, M. Cerletti, C. Dall’Osso, and A.J. Wagers

The C. elegans DAF-2 Insulin-Like Receptor is Abundantly Expressed in the Nervous System and Regulated by Nutritional Status

K.D. Kimura, D.L. Riddle, and G. Ruvkun

 

Regulation and Dysregulation of Metabolism

 

Surviving Starvation: Essential Role of the Ghrelin-Growth Hormone Axis

J.L. Goldstein, T.-j. Zhao, R.L. Li, D.P. Sherbet, G. Liang, and M.S. Brown

Transcriptional and Posttranscriptional Control of Cholesterol Homeostasis by Liver X Receptors

P. Tontonoz

Roles of FGF19 in Liver Metabolism

S. Kir, S.A. Kliewer, and D.J. Mangelsdorf

A New Approach to an Old Problem: Synthetic Biology Tools for Human Disease and Metabolism

D.R. Burrill, P.M. Boyle, and P.A. Silver

 

Signaling and Gene Regulation

 

Adenosine Monophosphate–Activated Protein Kinase: A Central Regulator of Metabolism with Roles in Diabetes, Cancer, and Viral Infection

D.G. Hardie

Regulated Histone Methyltransferase and Demethylase Complexes in the Control of Genes by Nuclear Receptors

A. Yokoyama, R. Fujiki, F. Ohtake, and S. Kato

Transcriptional Control of Cardiac Fuel Metabolism and Mitochondrial Function

T.C. Leone and D.P. Kelly

Metabolic Specialization of Mouse Embryonic Stem Cells

J. Wang, P. Alexander, S.L. McKnight

On Acetyl-CoA as a Gauge of Cellular Metabolic State

L. Cai and B.P. Tu

 

Metabolic Reprogramming

 

Nutrient-Dependent Acetylation Controls Basic Regulatory Metabolic Switches and Cellular Reprogramming

J.E. Dominy, Z. Gerhart-Hines, and P. Puigserver

Control of Glycolysis through Regulation of PFK1: Old Friends and Recent Additions

I. Mor, E.C. Cheung, and K.H. Vousden

ENTPD5, an Endoplasmic Reticulum (ER) UDPase, Alleviates ER Stress Induced by Protein Overloading in AKT-Activated Cancer Cells

Z. Shen, S. Huang, M. Fang, and X. Wang

MicroRNAs in Metabolism and Metabolic Diseases

V. Rottiers, S.H. Najafi-Shoushtari, F. Kristo, S. Gurumurthy, L. Zhong, Y. Li, D.E Cohen, R.E. Gerszten, N. Bardeesy, R. Mostoslavsky, and A.M. Näär

Metabolomics in Drug Target Discovery

J.D. Rabinowitz, J.G. Purdy, L. Vastag, T. Shenk, and E. Koyuncu

 

Fat, Intermediary Metabolism, and Exercise

 

Transcriptional Networks Controlling Adipocyte Differentiation

R. Siersbæk and S. Mandrup

Adiponectin, Adiponectin Receptors, and Epigenetic Regulation of Adipogenesis

T. Kadowaki, T. Yamauchi, H. Waki, M. Iwabu, M. Okada-Iwabu, and M. Nakamura

SIRT3 Regulates Mitochondrial Protein Acetylation and Intermediary Metabolism

M.D. Hirschey, T. Shimazu, J.-Y. Huang, B. Schwer, and E. Verdin

Regulation of Male Fertility by Bone

G. Karsenty

Regulation of Glycolysis and Gluconeogenesis by Acetylation of PKM and PEPCK

Y. Xiong, Q-Y. Lei, S. Zhao, and K-L. Guan

NAD⁺ as a Signaling Molecule Modulating Metabolism

C. Cantó and J. Auwerx

 

Metabolism and Cancer

 

Cancer Cell Metabolism

R.A. Cairns, I. Harris, S. McCracken, and T.W. Mak

Extracellular Matrix Regulation of Metabolism and Implications for Tumorigenesis

A.R. Grassian, J.L. Coloff, and J.S. Brugge

Metabolic Pathway Alterations that Support Cell Proliferation

M.G. Vander Heiden, S.Y. Lunt, T.L. Dayton, B.P. Fiske, W.J. Israelsen, K.R. Mattaini, N.I. Vokes, G. Stephanopoulos, L.C. Cantley, C.M. Metallo, and J.W. Locasale

Cancer and Altered Metabolism: Potential Importance of Hypoxia-Inducible Factor and 2-Oxoglutarate-Dependent Dioxygenases

W.G. Kaelin, Jr.

Regulation of Metabolism by Hypoxia-Inducible Factor 1

G.L. Semenza

mRNA Translation and Energy Metabolism in Cancer: The Role of the MAPK and mTORC1 Pathways

I. Topisirovic and N. Sonenberg

Therapeutic Targeting of Myc-Reprogrammed Cancer Cell Metabolism

C.V. Dang

 

Apoptosis and Autophagy

 

Integration of Apoptosis and Metabolism

C.H. Yi, H. Vakifahmetoglu-Norberg, and J. Yuan

Autophagy, Stress, and Cancer Metabolism: What Doesn’t Kill You Makes You Stronger

R. Mathew and E. White

Autophagy in Protein and Organelle Turnover

N. Mizushima

 

Summary: Back to the Future: Molecular Biology Meets Metabolism

S. McKnight

 

Author Index

Subject Index