© 2012 • 352 pp., illustrations, index
Hardcover • $135 • ISBN  978-1-936113-46-0

The synthesis of proteins by ribosomes is a fundamental cellular process. Cells must tightly control protein synthesis to maintain homeostasis and regulate proliferation, growth, differentiation, and development. Indeed, aberrant translational control is associated with cancer, several neurologic syndromes, and a group of genetic disorders termed

Preface

Principles of Translational Control: An Overview

John W.B. Hershey, Nahum Sonenberg, and Michael B. Mathews

The Structure and Function of the Eukaryotic Ribosome

Daniel N. Wilson and Jamie H. Doudna Cate

The Mechanism of Eukaryotic Translation Initiation: New Insights and Challenges

Alan G. Hinnebusch and Jon R. Lorsch

The Elongation, Termination, and Recycling Phases of Translation in Eukaryotes

Thomas E. Dever and Rachel Green

Single-Molecule Analysis of Translational Dynamics

Alexey Petrov, Jin Chen, Seán O’Leary, Albert Tsai, and Joseph D. Puglisi

The Current Status of Vertebrate Cellular mRNA IRESs

Richard J. Jackson

From Cis-Regulatory Elements to Complex RNPs and Back

Fátima Gebauer, Thomas Preiss, and Matthias W. Hentze

Regulation of mRNATranslation by Signaling Pathways

Philippe P. Roux and Ivan Topisirovic

Protein Secretion and the Endoplasmic Reticulum

Adam M. Benham

New Insights into Translational Regulation in the Endoplasmic Reticulum Unfolded Protein Response

Graham D. Pavitt and David Ron

P-Bodies and Stress Granules: Possible Roles in the Control of Translation and mRNA Degradation

Carolyn J. Decker and Roy Parker

mRNA Localization and Translational Control in Drosophila Oogenesis

Paul Lasko

Toward a Genome-Wide Landscape of Translational Control

Ola Larsson, Bin Tian, and Nahum Sonenberg

Imaging Translation in Single Cells Using Fluorescent Microscopy

Jeffrey A. Chao, Young J. Yoon, and Robert H. Singer

A Molecular Link between miRISCs and Deadenylases Provides New Insight into the Mechanism of Gene Silencing by MicroRNAs

Joerg E. Braun, Eric Huntzinger, and Elisa Izaurralde

Translational Control in Cancer Etiology

Davide Ruggero

Cytoplasmic RNA-Binding Proteins and the Control of Complex Brain Function

Jennifer C. Darnell and Joel D. Richter

Tinkering with Translation: Protein Synthesis in Virus-Infected Cells

Derek Walsh, Michael B. Mathews, and Ian Mohr

Emerging Therapeutics Targeting mRNATranslation

Abba Malina, John R. Mills, and Jerry Pelletier

Index