© 2004 • 1,050 pp., illus., color plates, glossary, appendix, index
Hardcover • $147 29.40 • ISBN  978-087969693-1
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This volume is a new edition of the most authoritative book on Prion Biology, first published in 1999 and edited by the Nobel Prize–winning founder of the field. This expanded edition has been completely updated, and includes chapters on therapeutics, and diagnostic methods and approaches.

  “Because of the increasing importance of prions to public health, and the burgeoning rate of discovery in prion biology, this is a timely occasion for a second edition of the book Prion Biology and Diseases.  As with the first edition (published in 1999), the extensively revised and updated second edition is edited and substantially written by Stanley Prusiner.

The book is comprehensive, authoritative, accessible and, for the most part, exciting to read. It will serve admirably as a standard of the new science of “prionology” for scientists, physicians and students.”
      —Nature Cell Biology

  “The Editor hoped this book would stimulate and tempt young investigators to prion research. It certainly informs the novice that there is more to prions than mad cows and cannibals! And for the established researcher? This book should make a useful reference text as data from an extensive number of studies are contained within the same volume.”
      —Microbiology Today

PRION BIOLOGY

Chapter 1: An Introduction to Prion Biology and Diseases

S.B. Prusiner

Chapter 2: Development of the Prion Concept

S.B. Prusiner

Chapter 3: Bioassays of Prions

S.B. Prusiner, J. Safar, and S.J. DeArmond

Chapter 4: Transmission and Replication of Prions

S.B. Prusiner, M.R. Scott, S.J. DeArmond, and G. Carlson

Chapter 5: Structural Studies of Prion Proteins

C. Govaerts, H. Wille, S.B. Prusiner, and F.E. Cohen

Chapter 6: Doppel, a New PrP–like Mammalian Protein

D. Westaway, L.E. Hood, and S.B. Prusiner

FUNGAL PRIONS

Chapter 7: Prions of Yeast and Filamentous Fungi: [URE3], [PSI⁺], [PIN⁺], and [Het–s]

R.B. Wickner, S.W. Liebman, and S.J. Saupe

TRANSGENETICS AND CELL BIOLOGY OF PRIONS

Chapter 8: Knockouts, Knockins, Transgenics, and Transplants in Prion Research

E. Flechsig, J.C. Manson, R. Barron, A. Aguzzi, and C. Weissmann

Chapter 9: Transgenetic Investigations of the Species Barrier and Prion Strains

M. Scott, D. Peretz, R.M. Ridley, H.F. Baker, S.J. DeArmond, and S.B. Prusiner

Chapter 10: Cell Biology of Prions

D.A. Harris, P.J. Peters, A. Taraboulos, V. Lingappa, S.J. DeArmond, and S.B. Prusiner

PRION DISEASES IN ANIMALS

Chapter 11: Scrapie, Chronic Wasting Disease, and Transmissible Mink Encephalopathy

S.B. Prusiner, E. Williams, J.–L. Laplanche, and M. Shinagawa

Chapter 12: Bovine Spongiform Encephalopathy and Related Diseases

G.A.H. Wells and J.W. Wilesmith

HUMAN PRION DISEASES

Chapter 13: Infectious and Sporadic Prion Diseases

R.G. Will, M.P. Alpers, D. Dormont, and L.B. Schonberger

Chapter 14: Inherited Prion Diseases

Q. Kong, W.K. Surewicz, R.B. Petersen, W. Zou, S.G. Chen, P. Gambetti, P. Parchi, S. Capellari, L. Goldfarb, P. Montagna, E. Lugaresi, P. Piccardo, and B. Ghetti

Chapter 15: Neuropathology of Prion Diseases

S.J. DeArmond, J.W. Ironside, E. Bouzamondo–Bernstein, D. Peretz, and J.R. Fraser

METHODOLOGY, BIOSAFETY, AND THERAPEUTICS

Chapter 16: Some Strategies and Methods for the Study of Prions

S.B. Prusiner, G. Legname, S.J. DeArmond, F.E. Cohen, J. Safar, D. Riesner, and K. Kaneko

Chapter 17: Biosafety Issues in Prion Diseases

H. Baron, J. Safar, D. Groth, S.J. DeArmond, and S.B. Prusiner

Chapter 18: Therapeutic Approaches to Prion Diseases

S.B. Prusiner, B.C.H. May, and F.E. Cohen

Glossary

Appendix

Index