This monograph, written by experts in the field, is devoted to the molecular analysis of addiction pathways in the brain. It provides an intensive overview of the fundamentals, stateoftheart advances, and major gaps in the cell and molecular biology of drug addiction within the broader context of neuroscience. Addiction research is a branch of neuroscience and psychology. The emphasis in this book is on hard science and the market for it will be found among research investigators and grad students within the field of neuroscience. The research presented is not only applicable to the study of drug abuse and addiction, but has clear implications for clarifying mechanisms of learning and memory, neuroadaptation, perception, volitional behavior, motivation, reward, and other disciplines of neuroscience.
1. Introduction, B.K. Madras
PART 1: GENETICS
2. Addiction Genetics and Genomics, G.R.Uhl
3. CatecholOmethyltransferase Genotype, Intermediate Phenotype, and Psychiatric Disorders, K. Xu and D. Goldman
4. Identifying Genes Affecting Addiction Risk in Animal Models, J.C. Crabbe
5. Endorphins, Gene Polymorphisms, Stress Responsivity, and Special Addictions: Selected Topics, M.J. Kreek
6. Imaging the Addicted Brain, N.D. Volkow, G.J. Wang, J.S. Fowler, and R.Z. Goldstein
7. Neurotoxin Effects of Drug of Abuse: Imaging and Mechanisms, D.F. Wong
PART 2: DEVELOPMENT AND DRUG ABUSE
8. Development of Midbrain Dopaminergic Pathways, M. Cooper and R. Zhou
PART 3: CELL BIOLOGY AND PHARMACOLOGY
9. Transporter Structure and Function, G. Rudnick
10. Neuronal Nicotinic Acetylcholine Receptors and Nicotine Dependence, A.R. Tapper, R. Nashmi, and H.A. Lester
11. Opioids as a Model for Cell Biological Studies of Addictive Drug Action, M. von Zastrow and C.J. Evans
12. Receptorreceptor Interactions Modulate Opioid Receptor Function, I. Gomes and L.A. Devi
13. The Endocannabinoid System: From Cell Biology to Therapy, D. Piomelli
14. Cocaine Neurobiology: From Targets to Treatment, B.K. Madras and Z. Lin
15. The Oligomerization of Gproteincoupled Receptors, M.M.C. Kong, B.F. ODowd, and S.R. George
16. The Critical Role of Adenosine A2a Receptors and Gi Βγ Subunits in Alcoholism and Addiction: From Cell Biology to Behavior, I. Diamond and L. Yao
17. Neurotransmitter Transporters: Mechanisms and Function, R. Edwards
PART 4: SYNAPTIC PLASTICITY AND ADDICTION
18. Synaptic Vesicle Trafficking and Drug Addiction in Synapsin Triple Knockout Mice, D. Gitler, J. Feng, Y. Takagishi, V.M. Pogorelov, R.M. Rodriguiz, B.J. Venton, P.E.M. Phillips, Y. Ren, H.T. Kao, M. Wightman, P. Greengard, W.C. Wetsel, and G.J. Augustine
19. Synaptic Plasticity in the Mesolimbic Dopamine System and Addiction, D. Saal and R.C. Malenka
20. Longterm Memory Storage in Aplysia, J.H. Schwartz
21. Molecular Mechanisms of Drug Addiction, E.J. Nestler
PART 5: SYSTEMS ANALYSIS OF DRUG ABUSE
22. Dynamic Analyses of Neural Representations Using the Statespace Modeling Paradigm, E.N. Brown and R. Barbieri
23. Quantitative Functional Genomics and Proteomics of Drug Abuse, W.M. Freeman and K.E. Vrana
Cell Biology of Addiction, a groundbreaking and comprehensive book, describes exquisite and rigorous scientific inquiry into the molecular and cellular underpinnings of addiction, examining, as Bertha K. Madras states in the introduction, genetic influences, biological targets of drugs, neurotoxicity, and the signaling pathways that trigger neuroadaptive processes to drive or contribute to compulsive and uncontrollable drug use, withdrawal, craving, and relapse. The chapters are based on a course designed by leaders in the field to teach this subject at the Cold Spring Harbor Laboratory to the next generation of neuroscientists, who now have the opportunity to unravel the powerful forces that propel the addicted patient and consequently overwhelm todays society in so many ways....
Readers of this exciting book will find it satisfying on two levelsthe scientific and the symbolic. Scientifically, it is indeed gratifying that so much of what we have learned about the functioning of the brain has been derived from attempts to elucidate the mechanistic underpinnings of addiction. And symbolically, we have reason for optimism because of the many basic neuroscientists who are devoting themselves to the challenge of understanding a disorder that affects so many.
The New England Journal of Medicine
This book has evolved from a course presented at Cold Spring Harbor Laboratory over the period 2001-2005. It claims to provide readers with an intensive overview of the fundamentals, state-of-the-art advances and major gaps in the cell and molecular biology of drug addiction within the broader context of neuroscience. Overall, it fulfills these claims.
To summarise, this book provides a very good overview for PhD students and those just entering the field. The established expert will also glean useful information, given the diversity of topics covered which are generally presented in a highly readable fashion.
British Neuroscience Association Bulletin