© 2008 • 1,114 pp., illus., index
Hardcover • $135 • ISBN  978-087969752-5

TGF-β is the prototype of a protein superfamily which, in humans, contains at least 35 members, including activins, inhibins, bone morphogenetic proteins, growth/differentiation factors, and Müllerian inhibiting substance. This monograph draws on the world’s leading laboratories to comprehensively cover all aspects of the biology of TGF-β and serve as a reference work for both specialists and researchers less familiar with the field.

  “The breadth and depth of the coverage of current TGF-β research is the most compelling feature of this book...[I]t is my recommendation that every principal investigator studying TGF-β should have a copy of this book...[T]he process of ‘getting up to speed’ becomes far less arduous.”
      —Development

  “The book includes numerous figures and tables, which make each chapter accessible and pleasant to read. This volume will be of interest both for basic scientists concerned with topics such as transcriptional control of TFG-β signaling, as well as for translational scientists and clinicians focused on agents used to target the TGF-β signaling pathway...In summary, this book can be considered as a true TGF-β family encyclopedia.”
      —The Quarterly Review of Biology

  “I found The TGF-β Family a great book. Tables and illustrations will surely prove useful in guiding the reader through complex problems and the book can be certainly recommended for teaching purposes. The clarity and comprehensiveness of the monograph, the eminence of the editors and authors, and the extensive bibliography at the end of each chapter make this book a ‘must-have’ reference for established investigators and clinicians and for newcomers attracted to TGF-β from various fields.”
      —Nature Cell Biology

Preface

Foreword

M.B. Sporn

1. The Discovery of TGF-β: A Historical Perspective

H.L. Moses and A.B. Roberts

2. TGF-β and the TGF-β Family

R. Derynck and M. Miyazono

CELL BIOLOGY

3. TGF-β: A Multipotential Cytokine

S.H. Schilling, A.B. Hjelmeland, J.N. Rich, and X.-F. Wang

4. Activins and Inhibins

E. Wiater and W. Vale

5. The Bone Morphogenetic Proteins

T. Katagiri, T. Suda, and K. Miyazono

SIGNALING

6. Signaling Receptors of the TGF-β Family

J.L. Wrana, B. Ozdamar, C. Le Roy, and H. Benchabane

7. TGF-β Bioavailability: Latency, Targeting, and Activation

B. Dabovic and D.B. Rifkin

8. Agonists and Antagonists of the TGF-β Family Ligands

C. Chang

9. TGF-β Signaling from Receptors to Smads

C.-H. Heldin

10. Transcriptional Control via Smads

X. Lin, Y.-G. Chen, and X.-H. Feng

11. Growth Control by TGF-β: Mechanisms Controlling Cell Cycle Progression and Apoptosis

P.M. Siegel and J. Massagué

12. Regulation of TGF-β Family Signaling by Inhibitory Smads

K. Miyazono

13. Structural Basis for TGF-β Family Receptor Assembly and Signaling Specificity

K. Lin and S. Choe

14. Non-Smad TGF-β Signaling Pathways

Y.E. Zhang

15. Regulation of the Smad Pathway by Signaling Cross-Talk

K. Luo

DIFFERENTIATION, DEVELOPMENT, AND PHYSIOLOGY

16. TGF-β Family Signaling in Early Postimplantation Development of the Mouse

S. Miura, M. Whitman, and Y. Mishina

17. TGF-β Family Signaling in Drosophila

G. Pyrowolakis, B. Hartmann, and M. Affolter

18. TGF-β Signaling in the Nematode C. elegans

G.I. Patterson and R.W. Padgett

19. TGF-β Family Signaling in Xenopus and Zebrafish Embryos

M. Whitman

20. TGF-β Family Signaling in Stem Cell Renewal and Differentiation

T. Watabe and K. Miyazono

21. TGF-β Family Signaling in Mesenchymal Differentiation

R. Derynck, E. Piek, R.A. Schneider, L. Choy, and T. Alliston

22. TGF-β Family Signaling in Skeletal Development, Maintenance, and Disease

T. Alliston, E. Piek, and R. Derynck

23. TGF-β Family in Epithelial Development

N.M. Muñoz and W.M. Grady

24. The TGF-β Family in Endothelial Cell Differentiation and Cardiovascular Development and Function

M.-J. Goumans, R. Carvalho, C. Mummery, and P. ten Dijke

25. TGF-β as a Regulator of Myeloid and Lymphoid Development and Function

J.J. Letterio and F.W. Ruscetti

26. The TGF-β Family in Neural and Neuronal Differentiation and Development

J. Samanta, M.A. Bonaguidi, and J.A. Kessler

27. The TGF-β Family in the Reproductive Tract

S.A. Pangas and M.M. Matzuk

CANCER AND DISEASE

28. TGF-β Signaling Pathway and Tumor Suppression

W.M. Grady and S.D. Markowitz

29. TGF-β Signaling in Epithelial–Mesenchymal Transition and Invasion and Metastasis

R.J. Akhurst

30. TGF-β and the Tumor Microenvironment

B. Bierie and H.L. Moses

31. TGF-β and Fibrosis

E.P. Böttinger

32. Development of TGF-β-based Therapeutic Agents: Capitalizing on TGF-β’s Mechanisms of Action and Signal Transduction Pathways

C.L. Arteaga and J.M. McPherson

33. BMP-based Therapeutics and the BMP Signaling Pathways

G. Bain, A.J. Celeste, and J.M. Wozney

Index