© 2000 • 1,020 pp., illus., index
Paperback • ISBN  0-87969-618-4

This title also available in: Cloth

Since the 1996 publication of Translational Control, there has been fresh interest in protein synthesis and recognition of the key role of translational control mechanisms in regulating gene expression. This new monograph updates and expands the scope of the earlier book but it also takes a fresh look at the field. In a new format, the first eight chapters provide broad overviews, while each of the additional twenty-eight has a focus on a research topic of more specific interest. The result is a thoroughly up-to-date account of initiation, elongation, and termination of translation, control mechanisms in development in response to extracellular stimuli, and the effects on the translational machinery of virus infection and disease. This book is essential reading for students entering the field and an invaluable resource for investigators of gene expression and its control.

  "In general, the editors are to be congratulated on assembling a high-powered collection of expert contributors to produce this large monograph, and, if you are seeking a snapshot of all the major topics of importance in the field of protein synthesis (particularly in eukaryotes) at the beginning of the 21st century, Translational Control of Gene Expression is the place to look …. I strongly recommend this publication as an authoritative source-book, both for students entering the field and established practitioners alike, and it should find its way onto many laboratory benches and library shelves."
      —Trends in Genetics

  "This book is the most complete and up-to-date review of translational control mechanisms. It is a must for students entering the field, and it will constitute for many years a major reference guide for any investigator who is seriously interested in the full picture of gene expression."
      —Journal of Cell Science

  "Whether you are an advanced student or an experienced researcher, if you need to bring yourself up to speed on the translational control of gene expression, then this is the book for you. In 36 chapters almost every aspect of translational control, including the mechanisms of initiation, elongation and termination, control during development, control in response to extracellular stimuli and control during virus infection or cancer are dealt with. As you would expect from a Cold Spring Harbor Monograph, the volume is comprehensive, scholarly and as ‘up-to-date’ as this type of multi-author volume can hope to be..I can recommend this volume to individual specialists and institutional libraries, both of which will get a lot of good value for their money."
      —Microbiology Today

Preface

Chapter 1: Origins and Principles of Translational Control

(M.B. Mathews, N. Sonenberg, and J.W.B. Hershey)

Chapter 2: Pathway and Mechanism of Initiation of Protein Synthesis

(J.W.B. Hershey and W.C. Merrick)

Chapter 3: Protein Bioynthesis Elongation Cycle

(W.C. Merrick and J. Nyborg)

Chapter 4: Comparative View of Initiation Site Selection Mechanisms

(R.J. Jackson)

Chapter 5: Mechanism and Regulation of Initiator Methionyl-tRNA Binding to Ribosomes

(A.G. Hinnebusch)

Chapter 6: Regulation of Ribosomal Recruitment in Eukaryotes

(B. Raught, A.-C. Gingras, and N. Sonenberg)

Chapter 7: Translational Control of Developmental Decisions

(M. Wickens, E.B. Goodwin, J. Kimble, S. Strickland, and M. Hentze)

Chapter 8: Viral Translational Strategies and Host Defense Mechanisms

(T. Pe’ery and M.B. Mathews)

Chapter 9: Ribosomal Subunit Joining

(T.V. Pestova, T.E. Dever, and C.U.T. Hellen)

Chapter 10: Physical and Functional Interactions between the mRNA Cap Structure and the Poly(A) Tail

(A. Sachs)

Chapter 11: Translation Termination: It’s Not the End of the Story

(E.M. Welch, W. Wang, and S.W. Peltz)

Chapter 12: Genetic Approaches to Translation Initiation in Saccharomyces cerevisiae

(T.F. Donahue)

Chapter 13: Double-stranded RNA-activated Protein Kinase PKR

(R.J. Kaufman)

Chapter 14: Heme-regulated eIF2 alpha Kinase

(J.-J. Chen)

Chapter 15: PERK and Translational Control by Stress in the Endoplasmic Reticulum

(D. Ron and H.P. Harding)

Chapter 16: Regulation of Translation Initiation in Mammalian Cells by Amino Acids

(S.R. Kimball and L.S. Jefferson)

Chapter 17: Translational Control during Heat Shock

(R.J. Schneider)

Chapter 18: Translational Control by Upstream Open Reading Frames

(A.P. Geballe and M.S. Sachs)

Chapter 19: Cellular Internal Ribosome Entry Site Elements and the Use of cDNA Microarrays in Their Investigation

(M.S. Carter, K.M. Kuhn, and P. Sarnow)

Chapter 20: Translational Control and Cancer

(J.W.B. Hershey and S. Miyamoto)

Chapter 21: Translational Control of Ferritin Synthesis

(T.A. Rouault and J.B. Harford)

Chapter 22: Translational Control of TOP mRNAs

(O. Meyuhas and E. Hornstein)

Chapter 23: S6 Phosphorylation and Signal Transduction

(S. Fumagalli and G. Thomas)

Chapter 24: Control of the Elongation Phase of Protein Synthesis

(C. Proud)

Chapter 25: Programmed Translational Frameshifting, Hopping, and Readthrough of Termination Codons

(P.J. Farabaugh, Q. Qian, and G. Stahl)

Chapter 26: Recoding UGA as Selenocysteine

(M.J. Berry)

Chapter 27: Influence of Polyadenylation-induced Translation on Metazoan Development and Neuronal Synaptic Function

(J.D. Richter)

Chapter 28: Interaction of mRNA Translation and mRNA Degradation in Saccharomyces cerevisiae

(D.C. Schwartz and R. Parker)

Chapter 29: Destabilization of Nonsense-containing Transcripts in Saccharomyces cerevisiae

(Jacobson and S.W. Peltz)

Chapter 30: Nonsense-mediated RNA Decay in Mammalian Cells: A Splicing-dependent Means to Down-regulate the Levels of mRNAs That Prematurely Terminate Translation

(L.E. Maquat)

Chapter 31: Translation Initiation on Picornavirus RNA

(G.J. Belsham and R.J. Jackson)

Chapter 32: Adenovirus Inhibition of Cellular Protein Synthesis and Preferential Translation of Viral mRNAs

(R.J. Schneider)

Chapter 33: Reovirus Translational Control

(A.J. Shatkin)

Chapter 34: Translational Reprogramming during Influenza Virus Infection

(S.-L. Tan, M. Gale, Jr., and M.G. Katze)

Chapter 35: Translational Control in Poxvirus-infected Cells

(B.L. Jacobs)

Chapter 36: Nontranslational Functions of Components of the Translational Apparatus

(T.G. Kinzy and E. Goldman)

Index