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Essentials of Glycobiology, Second Edition

Subject Area(s):  Molecular BiologyBiochemistry

Edited by Ajit Varki, University of California, San Diego; Richard D. Cummings, Emory University, School of Medicine, Atlanta; Jeffrey D. Esko, University of California, San Diego; Hudson H. Freeze, Burnham Institute for Medical Research, La Jolla; Pamela Stanley, Albert Einstein College of Medicine of Yeshiva University, New York; Carolyn R. Bertozzi, University of California, Berkeley; Gerald W. Hart, Johns Hopkins University School of Medicine, Baltimore; Marilynn E. Etzler, University of California, Davis

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For corrections to Essentials of Glycobiology, Second Edition, click HERE. (last updated August 2011) —

© 2009 • 784 pp., illus. glossary, study guide, index
Hardcover • $162.00 145.80 (click here to price in UK Pounds)
ISBN  978-087969770-9
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  •     Description    
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The sugar chains of cells—known collectively as glycans—play a variety of impressive, critical, and often surprising roles in biological systems. Glycobiology is the study of the roles of glycans in the growth and development, function, and survival of an organism. Glyco-related processes, described in vivid detail in the text, have become increasingly significant in many areas of basic research as well as biomedicine and biotechnology.

This new edition of Essentials of Glycobiology covers the general principles and describes the structure and biosynthesis, diversity, and function of glycans and their relevance to both normal physiologic processes and human disease. Several new chapters present significant advances that have occurred since the publication of the first edition. Three sections of note describe organismal diversity, advances in our understanding of disease states and related therapeutic applications, and the genomic view of glycobiology. “Glycomics,” analogous to genomics and proteomics, is the systematic study of all glycan structures of a given cell type or organism and paves the way for a more thorough understanding of the functions of these ubiquitous molecules.

The first edition of Essentials of Glycobiology represented also a notable experiment in publishing, as it became one of the first electronic textbooks. And, now, in recognition of its wide audience and the changing ways in which researchers and students learn and access information, the new edition of Essentials will be made available online simultaneously with the print edition. This novel experiment is the result of the collaborative efforts of the Cold Spring Harbor Laboratory Press, the National Center for Biotechnology Information, and the editors of the book. Written and edited by glycobiologists with experience in teaching and in research, this volume will be an invaluable resource, both for students and for established investigators in fields such as developmental biology, cell biology, neuroscience, immunology, and biochemistry who require a complete yet concise introduction to this burgeoning field.

Advance praise for the Second Edition:

“The basic principles of glycobiology are clearly articulated in this volume, and the roles of complex carbohydrates in disease are an important read for all biomedical scientists.”

—Peter Agre, M.D., Nobel Laureate in Chemistry, 2003

“Essentials of Glycobiology is a major resource for understanding these post-translational biochemical reactions that affect the function and fate of proteins produced by the genes that are profoundly changed by their added sugars.”

—Baruch S. Blumberg, Nobel Laureate in Medicine, 1976

“The second edition of Essentials of Glycobiology, superbly printed and illustrated, develops in simple and absolutely precise terms the complicated intricacies of glycobiology. I would have killed to get this encyclopedic treatise 40 years ago when I was working my way through this field.”

—Edmond H. Fischer, Nobel Laureate in Medicine, 1992




1. Historical Background and Overview
A. Varki and N. Sharon
2. Structural Basis of Glycan Diversity
C.R. Bertozzi and D. Rabuka
3. Cellular Organization of Glycosylation
A. Varki, J.D. Esko, and K.J. Colley
4. Glycosylation Precursors
H.H. Freeze and A.D. Elbein
5. Glycosyltransferases and Glycan-processing Enzymes
J.M. Rini, J.D. Esko, and A. Varki
6. Biological Roles of Glycans
A. Varki and J.B. Lowe
7. A Genomic View of Glycobiology
B. Henrissat, A. Surolia, and P. Stanley

8. N-Glycans
P. Stanley, H. Schachter, and N. Taniguchi
9. O-GalNAc Glycans
I. Brockhausen, H. Schachter, and P. Stanley
10. Glycosphingolipids
R.L. Schnaar, A. Suzuki, and P. Stanley
11. Glycosylphosphatidylinositol Anchors
M.A.J. Ferguson, T. Kinoshita, and G.W. Hart
12. Other Classes of ER/Golgi-derived Glycans
H.H. Freeze and R.S. Haltiwanger
13. Structures Common to Different Glycans
P. Stanley and R.D. Cummings
14. Sialic Acids
A. Varki and R. Schauer
15. Hyaluronan
V. Hascall and J.D. Esko
16. Proteoglycans and Sulfated Glycosaminoglycans
J.D. Esko, K. Kimata, and U. Lindahl
17. Nucleocytoplasmic Glycosylation
G.W. Hart and C.M.West
18. The O-GlcNAc Modification
G.W. Hart and Y. Akimoto

19. Evolution of Glycan Diversity
A. Varki, H.H. Freeze, and P. Gagneux
20. Eubacteria and Archaea
J.D. Esko, T.L. Doering, and C.R.H. Raetz
21. Fungi
R.D. Cummings and T.L. Doering
22. Viridiplantae
M.E. Etzler and D. Mohnen
23. Nematoda
R.D. Cummings and J.D. Esko
24. Arthropoda
M. Tiemeyer, S.B. Selleck, and J.D. Esko
25. Deuterostomes
H.H. Freeze, V.D. Vacquier, and J.D. Esko

26. Discovery and Classification of Glycan-binding Proteins
A. Varki, M.E. Etzler, R.D. Cummings, and J.D. Esko
27. Principles of Glycan Recognition
R.D. Cummings and J.D. Esko
28. R-type Lectins
R.D. Cummings and M.E. Etzler
29. L-type Lectins
M.E. Etzler, A. Surolia, and R.D. Cummings
30. P-type Lectins
A. Varki and S. Kornfeld
31. C-type Lectins
R.D. Cummings and R.P. McEver
32. I-type Lectins
A. Varki and P.R. Crocker
33. Galectins
R.D. Cummings and F.-T. Liu
34. Microbial Lectins: Hemagglutinins, Adhesins, and Toxins
J.D. Esko and N. Sharon
35. Proteins that Bind Sulfated Glycosaminoglycans
J.D. Esko and R.J. Linhardt

36. Glycans in Glycoprotein Quality Control
H.H. Freeze, J.D. Esko, and A.J. Parodi
37. Free Glycans as Signaling Molecules
M.E. Etzler and J.D. Esko
38. Glycans in Development and Systemic Physiology
A. Varki, H.H. Freeze, and V.D. Vacquier
39. Bacterial and Viral Infections
V. Nizet and J.D. Esko
40. Parasitic Infections
R.D. Cummings and S. Turco
41. Genetic Disorders of Glycan Degradation
H.H. Freeze
42. Genetic Disorders of Glycosylation
H.H. Freeze and H. Schachter
43. Glycans in Acquired Human Diseases
A. Varki and H.H. Freeze
44. Glycosylation Changes in Cancer
A. Varki, R. Kannagi, and B.P. Toole

45. Antibodies and Lectins in Glycan Analysis
R.D. Cummings and M.E. Etzler
46. Glycosylation Mutants of Cultured Cells
J.D. Esko and P. Stanley
47. Structural Analysis of Glycans
B. Mulloy, G.W. Hart, and P. Stanley
48. Glycomics
C.R. Bertozzi and R. Sasisekharan
49. Chemical and Enzymatic Synthesis of Glycans and Glycoconjugates
P.H. Seeberger, N. Finney, D. Rabuka, and C.R. Bertozzi
50. Chemical Tools for Inhibiting Glycosylation
J.D. Esko and C.R. Bertozzi
51. Glycans in Biotechnology and the Pharmaceutical Industry
C.R. Bertozzi, H.H. Freeze, A. Varki, and J.D. Esko

Study Guide


review:  “[T]his well-written text is a perfect entry point for an overview of this fascinating area of biology. For a broad audience interested in the myriad functions of glycans, particularly in vertebrate biology, this new edition of Essentials of Glycobiology is indeed essential.”
      —Nature Chemical Biology

review:  “Over 50 authors have contributed to this edition, which is reflected in the breadth of the chapter topics. Despite this wide coverage and authorship, the volume benefits from a coherent style with excellent new color illustrations that bring often complex and technical concepts to a readership that may not be familiar with some of the subtleties of glycobiology...

[T]he book provides a helpful overview of the important subject of glycobiology and will be a useful reference for students and researchers.”

review:  “The second edition of Essentials of Glycobiology will be an essential resource for newcomers seeking to become conversant with the area of glycobiology. Experts will enjoy both the breadth of up-to-date information and tripping over the many gemstones scattered throughout. A valuable touch is that each chapter offers up a list of additional references that provide interested students with detailed readings on a specific topic...I recommend Essentials of Glycobiology without reserve for both experts and students.”
      —The Quarterly Review of Biology

review:  “In general, the book is valuable not only for beginners and experts in Glycobiology, but also for many biochemists, molecular biologists, biotechnologists, and physicians.”

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