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A Bioinformatics Guide for Molecular BiologistsExperimental Design for Biologists, Second EditionImmunity and Tolerance

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Signal Transduction

This new textbook for the first time provides a comprehensive view of the subject by covering both the basic mechanisms involved and the roles of signal transduction in fundamental biological processes.

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The Skin and Its Diseases

This book examines the cells that make up the skin and their functions, as well as diseases such as psoriasis that affect the skin and new molecular strategies for treating these.

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Quickstart Molecular Biology: An Introductory Course for Mathematicians, Physicists, and Engineers

Editor’s Pick at 20% Savings!

This book is an introductory course in molecular biology for mathematicians, physicists, and engineers. It covers the basic features of DNA, proteins, and cells but in the context of recent technological advances, such as next generation sequencing and high-throughput screens, and their applications. This enables readers to move rapidly from the basics to an understanding of cutting-edge research in systems biology and genomics.

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Immunity and Tolerance
(Cold Spring Harbor Symposia on Quantitative Biology LXXVIII)

The 78th Symposium covers many aspects of the immune system including the genetics, biochemistry, molecular and cell biology, and developmental biology of immune responses. Fundamental biological insights are described as well as new approaches intended to harness the immune system to treat disease, particularly cancer. The specific topics addressed in this volume include:

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A Bioinformatics Guide for Molecular Biologists

The editors of this book approach the field of bioinformatics from the viewpoint of a molecular biologist, (1) arming the biologist with a basic understanding of the fundamental concepts in the field, (2) presenting approaches for using the tools from the standpoint of the data for which they are created, and (3) showing how the field of informatics is quickly adapting to the advancements in biology and biomedical technologies. It is a must-read for those interested in learning informatics techniques required for successful research and development in the laboratory.

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Experimental Design for Biologists, Second Edition

This handbook explains how to establish the framework for an experimental project, how to set up all of the components of an experimental system, design experiments within that system, determine and use the correct set of controls, and formulate models to test the veracity and resiliency of the data. This thoroughly updated edition is an essential source of theory and practical guidance for designing a research plan.

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Enjoy Your Cells

“The illustrations in Enjoy Your Cells are fantastic....this is no boring biology textbook. Rolph’s illustrations are rich with color and many have entertaining text bubbles....The book is jam-packed with information for both kids and parents. I’m a biologist and I learned new things from the book. Balkwill works hard to make all this material accessible to young minds...The book certainly made a lasting impression on my daughter.... She...even asked to bring the book to her preschool. It’s pretty neat to see how Enjoy Your Cells has given her a new way of looking at the living world.”

—Washington Post


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A new type of online review journal

• Spanning the complete spectrum of the molecular life sciences

• Article collections that build month by month

• Written and commissioned by experts in each field

Read these essential papers in this month’s issue:



Mark Lemmon and colleagues highlight the unique properties of the EGFR family.
The epidermal growth factor receptor (EGFR) was among the first receptor tyrosine kinases (RTKs) for which ligand binding was studied and for which the importance of ligand-induced dimerization was established. Read the full text.

Clathrins up close: Tom Kirchhausen details the components of clathrin-coated vesicles.
Clathrin is a molecular scaffold for vesicular uptake of cargo at the plasma membrane, where its assembly into cage-like lattices underlies the clathrin-coated pits of classical endocytosis. Read the full text.

Tony Hunter describes the origin and evolution of tyrosine phosphorylation research.
Tyrosine phosphorylation of proteins was discovered in 1979, but this posttranslational modification had been “invented” by evolution more than a billion years ago in single-celled eukaryotic organisms that were the antecedents of the first multicellular animals. Read the full text.

Visit here for this month’s complete table of contents and to learn more.

Cold Spring Harbor Perspectives in Biology
The Authoritative View
www.cshperspectives.org

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Father to Son: Truth, Reason, and Decency
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Next-Generation DNA Sequencing Informatics
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The TGF-β Family
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Landmark Papers in Yeast Biology
Cell Biology of Addiction

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Cold Spring Harbor Symposia 70 Year Online Archive graphic

Hundreds of important advances in biology were announced, debated, and distilled at the Cold Spring Harbor Symposia. These meetings, held each year on the tranquil grounds of one of the world’s leading research institutes, have been notable events in biomedical research since 1933. Now this essential archive, dating from 1933 to 2003, is available online for a one-time fee.

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The Complete, Renowned Book Series Now Online!

From the Preface of Volume 14, Nucleases: In August 1981, at the suggestion of Jim Watson, a meeting was held at Cold Spring Harbor on the topic of nucleases. The idea was to bring together people who study these enzymes, but who do not usually meet as a group because their individual interests in nucleases are primarily in the context of some other field. Historically, nucleases have not usually been considered a field in their own right, rather they have been studied because of their role in some particular biological phenomena such as the four R’s—Replication, Recombination, Repair, and Restriction.

The CSH Monograph Archive offers the complete collection of scholarly monographs published by Cold Spring Harbor Laboratory Press from 1970 to 2009. The archive’s 59 full-text volumes provide the life science community with definitive reviews of progress in areas of molecular, cell, and developmental biology, genetics, evolutionary biology, neuroscience, cancer biology, and molecular pathology. Each text is written and commissioned by foremost researchers in their particular discipline.

It is available online as a complete collection for one-time purchase (with perpetual access) or on pay-per-view basis by book chapter.