© 2012 • 305 pp., illus., index
Hardcover • $135 • ISBN  978-1-936113-21-7

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Type 1 diabetes, also known as juvenile-onset or insulin-dependent diabetes mellitus (IDDM), is caused by destruction of insulin-producing

Preface

The Pathogenesis and Natural History of Type 1 Diabetes

Mark A. Atkinson

Breakdown in Peripheral Tolerance in Type 1 Diabetes in Mice and Humans

Lukas T. Jeker, Hélène Bour-Jordan, and Jeffrey A. Bluestone

Generating β Cells from Stem Cells—The Story So Far

Matthias Hebrok

Endoplasmic Reticulum Stress, Pancreatic β-Cell Degeneration, and Diabetes

Feroz R. Papa

Genetics of Type 1 Diabetes

Janelle A. Noble and Henry A. Erlich

Humoral Autoimmunity in Type 1 Diabetes: Prediction, Significance, and Detection of Distinct Disease Subtypes

Massimo Pietropaolo, Roberto Towns, and George S. Eisenbarth

Immunologic and Metabolic Biomarkers of β-Cell Destruction in the Diagnosis of Type 1 Diabetes

Jasmin Lebastchi and Kevan C. Herold

Islet Autoantigens: Structure, Function, Localization, and Regulation

Peter Arvan, Massimo Pietropaolo, David Ostrov, and Christopher J. Rhodes

Do MHCII-Presented Neoantigens Drive Type 1 Diabetes and Other Autoimmune Diseases?

Philippa Marrack and John W. Kappler

Antigen Targets of Type 1 Diabetes Autoimmunity

Bart O. Roep and Mark Peakman

The Hygiene Hypothesis: An Explanation for the Increased Frequency of Insulin-Dependent Diabetes

Jean-François Bach and Lucienne Chatenoud

Environmental Triggers of Type 1 Diabetes

Mikael Knip and Olli Simell

Virus Infections in Type 1 Diabetes

Ken T. Coppieters, Tobias Boettler, and Matthias von Herrath

Connecting Type 1 and Type 2 Diabetes through Innate Immunity

Justin I. Odegaard and Ajay Chawla

Advancing Animal Models of Human Type 1 Diabetes by Engraftment of Functional Human Tissues in Immunodeficient Mice

Michael A. Brehm, Alvin C. Powers, Leonard D. Shultz, and Dale L. Greiner

Antigen-Specific Therapeutic Approaches in Type 1 Diabetes

Xavier Clemente-Casares, Sue Tsai, Carol Huang, and Pere Santamaria

Clinical Immunologic Interventions for the Treatment of Type 1 Diabetes

Lucienne Chatenoud, Katharina Warncke, and Anette-G. Ziegler

Update on Islet Transplantation

Michael McCall and A.M. James Shapiro

Index