© 2011 • 522 pp., illus. (62 4C and 11 B&W), index
Hardcover • $135 • ISBN  978-1-936113-43-9

Angiogenesis is the process by which new blood vessels are generated from preexisting vessels. It is vital for proper embryonic development, patterning of the vascular system, and wound healing. It is rate limiting in cancer progression, because the formation of new blood vessels is essential for growth and survival of tumors.

Written and edited by experts in the field, this volume reviews the mechanisms of angiogenesis that operate in normal development and in diseases such as cancer. The contributors review the biology of endothelial cells, describing the specific roles of tip and stalk cells in vessel sprouting and lumen formation. They discuss the key angiogenic regulators (e.g., vascular endothelial growth factor [VEGF]), as well as antiangiogenic agents including microRNAs, thrombospondins, and semaphorins. Therapeutic approaches that target pathological angiogenesis, such as the ongoing clinical trials of anti-VEGF drugs, are also covered.

This volume, which includes discussions of other vascular dysfunctions (e.g., arteriovenous malformations) and comparisons between the blood vascular system and the lymphatic system, is a vital reference for developmental and cancer biologists, as well as anyone seeking to understand the biology and pathology of the vascular system.

Preface

ENDOTHELIAL CELLS, ANGIOGENESIS

Endothelial Cell Heterogeneity

William C. Aird

Human Endothelial Progenitor Cells

Mervin C. Yoder

VEGF-Directed Blood Vessel Patterning: From Cells to Organisms

Victoria L. Bautch

VEGF and Notch in Tip and Stalk Cell Selection

Raquel Blanco and Holger Gerhardt

Tips, Stalks, Tubes: Notch-Mediated Cell Fate Determination and Mechanisms of Tubulogenesis during Angiogenesis

Jennifer J. Tung, Ian W. Tattersall, and Jan Kitajewski

Vascular Lumen Formation

Eckhard Lammert and Jennifer Axnick

miRNAs as Modulators of Angiogenesis

Shira Landskroner-Eiger, Isabelle Moneke, and William C. Sessa

 

LYMPHANGIOGENESIS

Myeloid Cells and Lymphangiogenesis

Adrian Zumsteg and Gerhard Christofori

The New Era of the Lymphatic System: No Longer Secondary to the Blood Vascular System

Inho Choi, Sunju Lee, and Young-Kwon Hong

 

VASCULAR DEVELOPMENT

Vascular Development in the Zebrafish

Aniket V. Gore, Kathryn Monzo, Young R. Cha, Weijun Pan, and Brant M. Weinstein

Molecular Parallels between Neural and Vascular Development

Anne Eichmann and Jean-Léon Thomas

 

ANGIOGENESIS STIMULATORS AND INHIBITORS

Signal Transduction by Vascular Endothelial Growth Factor Receptors

Sina Koch and Lena Claesson-Welsh

Vascular Hyperpermeability, Angiogenesis, and Stroma Generation

Janice A. Nagy, Ann M. Dvorak, and Harold F. Dvorak

PIGF: A Multitasking Cytokine with Disease-Restricted Activity

Mieke Dewerchin and Peter Carmeliet

The Complex Role of Angiopoietin-2 in the Angiopoietin–Tie Signaling Pathway

Gavin Thurston and Christopher Daly

Molecular Basis for the Regulation of Angiogenesis by Thrombospondin-1 and -2

Patrick R. Lawler and Jack Lawler

Semaphorins in Angiogenesis and Tumor Progression

Gera Neufeld, Adi D. Sabag, Noa Rabinovicz, and Ofra Kessler

 

VASCULAR PATHOLOGY

Tumor Endothelial Cells

Andrew C. Dudley

Infantile Hemangioma—Mechanism(s) of Drug Action on a Vascular Tumor

Shoshana Greenberger and Joyce Bischoff

Endothelial Cell-to-Cell Junctions: Adhesion and Signaling in Physiology and Pathology

Maria Grazia Lampugnani

av Integrins in Angiogenesis and Cancer

Sara M. Weis and David A. Cheresh

Vascular Normalization as a Therapeutic Strategy for Malignant and Nonmalignant Disease

Shom Goel, Andus Hon-Kit Wong, and Rakesh K. Jain

Antiangiogenic Therapy for Ischemic Retinopathies

Motasem Al-Latayfeh, Paolo S. Silva, Jennifer K. Sun, and Lloyd Paul Aiello

Angiogenic Factors in Preeclampsia and Related Disorders

Ana Sofia Cerdeira and S. Ananth Karumanchi

The Role of the Tumor Microenvironment in Regulating Angiogenesis

Randolph S. Watnick

Common Polymorphisms in Angiogenesis

Michael S. Rogers and Robert J. D’Amato

 

VASCULAR ANOMALIES

Arteriovenous Malformations and Other Vascular Malformation Syndromes

Kevin J. Whitehead, Matthew C.P. Smith, and Dean Y. Li

Vascular Anomalies: From Genetics toward Models for Therapeutic Trials

Melanie Uebelhoer, Laurence M. Boon, and Miikka Vikkula

 

CLINICAL APPLICATIONS, EVALUATIONS

Anti-VEGF Therapies in the Clinic

Kellen L. Meadows and Herbert I. Hurwitz

The VEGF Pathway in Cancer and Disease: Responses, Resistance, and the Path Forward

Mark W. Kieran, Raghu Kalluri, and Yoon-Jae Cho

Index