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Landmark Papers in Yeast Biology

Subject Area(s):  Cell BiologyGenetics and Genome ScienceMolecular BiologyYeast

Edited by Patrick Linder, University of Geneva; David Shore, University of Geneva; Michael N. Hall, Biozentrum, University of Basel

© 2006 • 306 pp., index, CD
Printed hardcover • $99 24.75 • ISBN  978-087969643-6
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Yeast has been a preeminent experimental organism of genetic research for more than 50 years. Progress in the field has provided the conceptual framework that has driven experiments in many areas of biology. Landmark Papers in Yeast Biology consists of essays by prominent scientists on the context and significance of 71 carefully selected research papers, which are reprinted on the accompanying CD.  The papers include early, hard–to–find classics as well as more recent advances in areas such as signal transduction, membrane trafficking, protein turnover, and genomics. This collection has unique value for all scholars of yeast and could provide the foundation for a literature–based course on molecular cell biology.  As Jasper Rine notes in his eloquent introduction, the editors and contributors share the belief that “deep study of the agreed–on classics is the best training for learning how to recognize those contemporary papers worthy of our personal time....”



review:  “This book, dedicated to the late, great yeast biologist Ira Herskowitz, is a delightful collection of essays that summarizes landmark papers in key areas of the cell and molecular biology of Saccharomyces cerevisiae and Schizosaccharomyces pombe. The volume is designed as a retrospective covering the development of key areas over a period of some 60 years up to around 2002. The editors and contributors have done a terrific job in selecting the best of the best.  For added value we have a DVD with PDF files of all the papers that are covered.  What is often difficult but vital in teaching is to explain the historical development of an expansive field. Here is an extraordinarily helpful aid to that end, and a great read for anyone at the coal–face of yeast genetics. One of the most useful books I have seen in the field in years.”
      —Microbiology Today

review:  “[T]his book contains a history of ideas and thinking within cell and molecular biology, in addition to a wealth of biological information about yeast biology. Who might be interested in reading such a book, and at whom is it aimed? One readership will be yeast scientists like myself who like to look back. However it seems that the intended readership is advanced students—presumably graduate research students—taking advanced courses in yeast biology or aspects of molecular cell biology more generally. The presence of (quite challenging) set questions based on the landmark papers at the end of each chapter certainly suggests a teaching role for the book...In my view it would be valuable for PhD students entering yeast research to acquire some understanding of the roots of the field and especially of the ideas involved, and this book provides an excellent entry point.”
      —Genetical Research

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Introduction, 1 
Jasper Rine

Section 1 Cytoplasmic Inheritance, 11 
Susan W. Liebman and Fred Sherman
Ephrussi B., Hottinguer H., and Tavlitzki J. 1949. Action de l’acriflavine sur les levures. II. Étude génétique du mutant “petite colonie”
Thomas D.Y. and Wilkie D. 1968. Recombination of mitochondrial drug-resistance factors in Saccharomyces cerevisiae
Tzagoloff A., Akai A., Needleman R.B., and Zulch G. 1975. Assembly of the mitochondrial membrane system. Cytoplasmic mutants of Saccharomyces cerevisiae with lesions in enzymes of the respiratory chain and in the mitochondrial ATPase
Cox B.S. 1965. Ψ, a cytoplasmic suppressor of super-suppressor in yeast
Wickner R.B. 1994. [URE3] as an altered URE2 protein: Evidence for a prion analog in Saccharomyces cerevisiae

Section 2 Homologous Recombination, 33 
Lorraine Symington
Hurst D.D., Fogel S., and Mortimer R.K. 1972. Conversion-associated recombination in yeast (hybrids/meiosis/tetrads/marker loci/models)
Nicolas A., Treco D., Schultes N.P., and Szostak J.W. 1989. An initiation site for meiotic gene conversion in the yeast Saccharomyces cerevisiae
Cao L., Alani E., and Kleckner N. 1990. A pathway for generation and processing of double-strand breaks during meiotic recombination in S. cerevisiae
Allers T. and Lichten M. 2001. Differential timing and control of noncrossover and crossover recombination during meiosis

Section 3 Chromosome Replication and Segregation, 49 
Carol S. Newlon
Stinchcomb D.T., Struhl K., and Davis R.W. 1979. Isolation and characterisation of a yeast chromosomal replicator
Brewer B.J. and Fangman W.L. 1987. The localization of replication origins on ARS plasmids in S. cerevisiae
Bell S.P. and Stillman B. 1992. ATP-dependent recognition of eukaryotic origins of DNA replication by a multiprotein complex
Lundblad V. and Szostak J.W. 1989. A mutant with a defect in telomere elongation leads to senescence in yeast
Clarke L. and Carbon J. 1980. Isolation of a yeast centromere and construction of functional small circular chromosomes

Section 4 Transcription, 67 
Fred Winston
Matsumoto K., Toh-e A., and Oshima Y. 1978. Genetic control of galactokinase synthesis in Saccharomyces cerevisiae: Evidence for constitutive expression of the positive regulatory gene gal4
Guarente L., Yocum R.R., and Gifford P. 1982. A GAL10-CYC1 hybrid yeast promoter identifies the GAL4 regulatory region as an upstream site
Brent R. and Ptashne M. 1985. A eukaryotic transcriptional activator bearing the DNA specificity of a prokaryotic repressor
Hirschhorn J.N., Brown S.A., Clark C.D., and Winston F. 1992. Evidence that SCF2/ SWI2 and SNF5 activate transcription in yeast by altering chromatin structure
Thompson C.M., Koleske A.J., Chao D.M., and Young R.A. 1993. A multisubunit complex associated with the RNA polymerase II CTD and TATA-binding protein in yeast

Section 5 Translation, 85 
Alan G. Hinnebusch
Sherman F., Stewart J.W., and Schweingruber A.M. 1980. Mutants of yeast initiating translation of iso-1-cytochrome c within a region spanning 37 nucleotides
Donahue T.F., Cigan A.M., Pabich E.K., and Castilho Valavicius B. 1988. Mutations at a Zn(II) finger motif in the yeast eIF-2β gene alter ribosomal start-site selection during the scanning process
Mueller P.P. and Hinnebusch A.G. 1986. Multiple upstream AUG codons mediate translational control of GCN4, 94
Altmann M., Sonenberg N., and Trachsel H. 1989. Translation in Saccharomyces cerevisiae: Initiation factor 4E-dependent cell-free system vTarun S.Z., Jr., Wells S.E., Deardorff J.A., and Sachs A.B. 1997. Translation initiation factor eIF4G mediates in vitro poly(A) tail-dependent translation

Section 6 Cell Division, 109 
Kim Nasmyth
Diffley J.F.X., Cocker J.H., Dowell S.J., and Rowley A. 1994. Two steps in the assembly of complexes at yeast replication origins in vivo
Irniger S., Piatti S., Michaelis C., and Nasmyth K. 1995. Genes involved in sister chromatid separation are needed for B-type cyclin proteolysis in budding yeast
Nurse P. and Thuriaux P. 1980. Regulatory genes controlling mitosis in the fission yeast Schizosaccharomyces pombe
Weinert T.A. and Hartwell L.H. 1988. The RAD9 gene controls the cell cycle response to DNA damage in Saccharomyces cerevisiae

Section 7 Cell Growth, 127 
James R. Broach
Johnston G.C., Pringle J.R., and Hartwell L.H. 1977. Coordination of growth with cell division in the yeast Saccharomyces cerevisiae
Toda T., Uno I., Ishikawa T., Powers S., Kataoka T., Broek D., Cameron S., Broach J., Matsumoto K., and Wigler M. 1985. In yeast, RAS proteins are controlling elements of adenylate cyclase
Cameron S., Levin L., Zoller M., and Wigler M. 1988. cAMP-independent control of sporulation, glycogen metabolism, and heat shock resistance in S. cerevisiae
Barbet N.C., Schneider U., Helliwell S.B., Stansfield I., Tuite M.F., and Hall M.N. 1996. TOR controls translation initiation and early G1 progression in yeast

Section 8 Differentiation: Mating and Filamentation, 141 
George F. Sprague, Jr.
Strathern J., Hicks J., and Herskowitz I. 1981. Control of cell type in yeast by the mating type locus: The α1-α2 hypothesis
Bender A. and Sprague G.F., Jr. 1987. MATα1 protein, a yeast transcription activator, binds synergistically with a second protein to a set of cell-type-specific genes
Keleher C.A., Redd M.J., Schultz J., Carlson M., and Johnson A.D. 1992. Ssn6-Tup1 is a general repressor of transcription in yeast
Hicks J.B. and Herskowitz I. 1977. Interconversion of yeast mating types. II. Restoration of mating ability to sterile mutants in homothallic and heterothallic strains
Gimeno C.J., Ljungdahl P.O., Styles C.A., and Fink G.R. 1992. Unipolar cell divisions in the yeast S. cerevisiae lead to filamentous growth: Regulation by starvation and RAS

Section 9 Meiosis and Spore Development, 157 
Rochelle E. Esposito
Esposito R.E., Frink N., Bernstein P., and Esposito M.S. 1972. The genetic control of sporulation in Saccharomyces. II. Dominance and complementation of mutants of meiosis and spore formation
Kassir Y., Granot D., and Simchen G. 1988. IME1, a positive regulator gene of meiosis in S. cerevisiae
Sym M., Engebrecht J.A., and Roeder G.S. 1993. ZIP1 is a synaptonemal complex protein required for meiotic chromosome synapsis
Watanabe Y. and Nurse P. 1999. Cohesin Rec8 is required for reductional chromosome segregation at meiosis
Hepworth S.R., Friesen H., and Segall J. 1998. NDT80 and the meiotic recombination checkpoint regulate expression of middle sporulation-specific genes in Saccharomyces cerevisiae

Section 10 Signal Transduction, 193 
Jeremy Thorner
Hartwell L.H. 1980. Mutants of Saccharomyces cerevisiae unresponsive to cell division control by polypeptide mating hormone
Whiteway M., Hougan L., Dignard D., Thomas D.Y., Bell L., Saari G.C., Grant F.J., O’Hara P., and MacKay V.L. 1989. The STE4 and STE18 genes of yeast encode potential β and γ subunits of the mating factor receptor-coupled G protein
Stevenson B.J., Rhodes N., Errede B., and Sprague G.F., Jr. 1992. Constitutive mutants of the protein kinase STE11 activate the yeast pheromone response pathway in the absence of the G protein
Choi K-Y., Satterberg B., Lyons D.M., and Elion E.A. 1994. Ste5 tethers multiple protein kinases in the MAP kinase cascade required for mating in S. cerevisiae

Section 11 Cytoskeleton and Morphogenesis, 211 
John R. Pringle
Byers B. and Goetsch L. 1975. Behavior of spindles and spindle plaques in the cell cycle and conjugation of Saccharomyces cerevisiae
Rout M.P. and Kilmartin J.V. 1990. Components of the yeast spindle and spindle pole body
Jacobs C.W., Adams A.E.M., Szaniszlo P.J., and Pringle J.R. 1988. Functions of microtubules in the Saccharomyces cerevisiae cell cycle
Kilmartin J.V. and Adams A.E.M. 1984. Structural rearrangements of tubulin and actin during the cell cycle of the yeast Saccharomyces
Sloat B.F., Adams A., and Pringle J.R. 1981. Roles of the CDC24 gene product in cellular morphogenesis during the Saccharomyces cerevisiae cell cycle
Chant J. and Herskowitz I. 1991. Genetic control of bud site selection in yeast by a set of gene products that constitute a morphogenetic pathway
Lew D.J. and Reed S.I. 1993. Morphogenesis in the yeast cell cycle: Regulation by Cdc28 and cyclins

Section 12 Membrane Traffic, 243 
Randy Schekman
Novick P., Field C., and Schekman R. 1980. Identification of 23 complementation groups required for post-translational events in the yeast secretory pathway
Salminen A. and Novick P.J. 1987. A ras-like protein is required for a post-Golgi event in yeast secretion
Schu P.V., Takegawa K., Fry M.J., Stack J.H., Waterfield M.D., and Emr S.D. 1993. Phosphatidylinositol 3-kinase encoded by yeast VPS34 gene essential for protein sorting
Lewis M.J., Sweet D.J., and Pelham H.R.B. 1990. The ERD2 gene determines the specificity of the luminal ER protein retention system

Section 13 Protein Translocation, 253 
Howard Riezman
Hall M.N., Hereford L., and Herskowitz I. 1984. Targeting of E. coli β-galactosidase to the nucleus in yeast
Deshaies R.J. and Schekman R. 1987. A yeast mutant defective at an early stage in import of secretory protein precursors into the endoplasmic reticulum
Schleyer M. and Neupert W. 1985. Transport of proteins into mitochondria: Translocational intermediates spanning contact sites between outer and inner membranes
Eilers M. and Schatz G. 1986. Binding of a specific ligand inhibits import of a purified precursor protein into mitochondria

Section 14 Ubiquitination and Protein Turnover, 267 
Mark Hochstrasser
Bachmair A., Finley D., and Varshavsky A. 1986. In vivo half-life of a protein is a function of its amino-terminal residue
Hiller M.M., Finger A., Schweiger M., and Wolf D.H. 1996. ER degradation of a misfolded luminal protein by the cytosolic ubiquitin-proteasome pathway
Kölling R. and Hollenberg C.P. 1994. The ABC-transporter Ste6 accumulates in the plasma membrane in a ubiquitinated form in endocytosis mutants
Schwob E., Böhm T., Mendenhall M.D., and Nasmyth K. 1994. The B-type cyclin kinase inhibitor p40SIC1 controls the G1 to S transition in S. cerevisiae
Mizushima N., Noda T., Yoshimori T., Tanaka Y., Ishii T., George M.D., Klionsky D.J., Ohsumi M., and Ohsumi Y. 1998. A protein conjugation system essential for autophagy

Section 15 Genomics, 285 
Mark Johnston and Philip Hieter
Petes T.D. and Botstein D. 1977. Simple Mendelian inheritance of the reiterated ribosomal DNA of yeast
Olson M.V., Dutchik J.E., Graham M.Y., Brodeur G.M., Helms C., Frank M., MacCollin M., Scheinman R., and Frank T. 1986. Random-clone strategy for genomic restriction mapping in yeast
Oliver S.G., van der Aart Q.J., Agostoni-Carbone M.L., Aigle M., Alberghina L., Alexandraki D., Antoine G., Anwar R., Ballesta J.P.M., Benit P., et al. 1992. The complete DNA sequence of yeast chromosome III
Winzeler E.A., Richards D.R., Conway A.R., Goldstein A.L., Kalman S., McCullough M.J., McCusker J.H., Stevens D.A., Wodicka L., Lockhart D.J., and Davis R.W. 1998. Direct allelic variation scanning of the yeast genome
Giaever G., Chu A.M., Ni L., Connelly C., Riles L., Véronneau S., Dow S., Lucau-Danila A., Anderson K., André B., et al. 2002. Functional profiling of the Saccharomyces cerevisiae genome
Index, 301


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