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HIV: From Biology to Prevention and Treatment


Subject Area(s):  DiseasesImmunology, Vaccines, and Therapeutic ProteinsInfectious Diseases

Edited by Frederic D. Bushman, University of Pennsylvania School of Medicine;  Gary J. Nabel, NIAID, National Institutes of Health; Ronald Swanstrom, University of North Carolina at Chapel Hill

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© 2011 • 572 pp., illus. (95 4C and 4 B&W), index
Hardcover • $135 • ISBN  978-1-936113-40-8


Description

The worldwide AIDS epidemic makes research on HIV, the disease processes it induces, and potential HIV therapies among the most critical in biomedical science. Furthermore, the basic biology of HIV infections provides a model for a more general understanding of retroviruses and their hosts.

Written and edited by experts in the field, this collection from Cold Spring Harbor Perspectives in Medicine provides a comprehensive review of HIV research, covering everything from the pathogenesis of HIV infection to prevention. Contributors explore the origins and evolution of HIV, the HIV replication cycle, host–virus interactions, host immune responses, and HIV transmission. Vaccines, cell and gene therapies, antiretroviral drugs, microbicides, and behavioral strategies for the treatment and prevention of HIV infections are also explored.

This volume, which includes discussions of social and economic factors that affect HIV transmission and treatment, is an essential reference for virologists, cell and molecular biologists, and immunologists, as well as epidemiologists, physicians, and other public health professionals.

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Contents

Preface
 
Origins of HIV and the AIDS Pandemic
Paul M. Sharp and Beatrice H. Hahn
 
HIV REPLICATION
 
HIV: Cell Binding and Entry
Craig B. Wilen, John C. Tilton, and Robert W. Doms
HIV-1 Reverse Transcription
Wei-Shau Hu and Stephen H. Hughes
HIV DNA Integration
Robert Craigie and Frederic D. Bushman
Transcriptional and Posttranscriptional Regulation of HIV-1 Gene Expression
Jonathan Karn and C. Martin Stoltzfus
HIV Assembly, Budding, and Maturation
Wesley I. Sundquist and Hans-Georg Kraüsslich
HIV Restriction Factors and Mechanisms of Evasion
Michael H. Malim and Paul D. Bieniasz
 
HIV TRANSMISSION AND PATHOGENESIS
 
HIV Transmission
George M. Shaw and Eric Hunter
HIV-1 Pathogenesis: The Virus
Ronald Swanstrom and John Coffin
HIV Pathogenesis: Dynamics and Genetics of Viral Populations and Infected Cells
John Coffin and Ronald Swanstrom
HIV Pathogenesis: The Host
A.A. Lackner, Michael M. Lederman, and Benigno Rodriguez
The Antibody Response against HIV-1
Julie Overbaugh and Lynn Morris
The T-Cell Response to HIV
Bruce Walker and Andrew McMichael
Innate Immune Control of HIV
Mary Carrington and Galit Alter
HIV Latency
Robert F. Siliciano and Warner C. Greene
HIV-1-Related Central Nervous System Disease: Current Issues in Pathogenesis, Diagnosis, and Treatment
Serena Spudich and Francisco González-Scarano
Nonpathogenic Simian Immunodeficiency Virus Infections
Nichole R. Klatt, Guido Silvestri, and Vanessa Hirsch
 
THERAPY AND PREVENTION
 
HIV-1 Antiretroviral Drug Therapy
Eric J. Arts and Daria J. Hazuda
Novel Cell and Gene Therapies for HIV
James A. Hoxie and Carl H. June
The HIV-1 Epidemic: Low- to Middle-Income Countries
Yiming Shao and Carolyn Williamson
The HIV Epidemic: High-Income Countries
Sten H. Vermund and Andrew J. Leigh-Brown
Host Genes Important to HIV Replication and Evolution
Amalio Telenti and Welkin E. Johnson
Vaccine Design for CD8 T Lymphocyte Responses
Richard A. Koup and Daniel C. Douek
Rational Design of Vaccines to Elicit Broadly Neutralizing Antibodies to HIV-1
Peter D. Kwong, John R. Mascola, and Gary J. Nabel
Lessons in Nonhuman Primate Models for AIDS Vaccine Research: From Minefields to Milestones
Jeffrey D. Lifson and Nancy L. Haigwood
Human Immunodeficiency Virus Vaccine Trials
Robert J. O’Connell, Jerome H. Kim, Lawrence Corey, and Nelson L. Michael
Microbicides: Topical Prevention against HIV
Robin J. Shattock and Zeda Rosenberg
HIV Prevention by Oral Preexposure Prophylaxis
Walid Heneine and Angela Kashuba
Behavioral and Biomedical Combination Strategies for HIV Prevention
Linda-Gail Bekker, Chris Beyrer, and Thomas C. Quinn
 
Index
 
          
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