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(Cold Spring Harbor Monograph Series 46)

Book Series:  Cold Spring Harbor Monograph Series
Subject Area(s):  Genetics and Genome Science

Edited by Hillary E. Sussman, Cold Spring Harbor Laboratory; Maria A. Smit, Cold Spring Harbor Laboratory

© 2006 • 475 pp., illus., index
Hardcover • $139 34.75 • ISBN  978-087969806-5
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This title also available in: Paperback


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Hundreds of genomes have been completely sequenced in the past decade, significantly advancing our understanding of genome structure and function. Genomes comprises a collection of review articles reprinted from the 10th Anniversary issue of the journal Genome Research that capture the status of genomic research in a selection of model species—from microbes to human.

Written by leaders in the field, each chapter focuses on a kingdom, group, or species and offers a unique perspective on the history, the current status, and future of genomics research. Topics addressed include gene regulatory networks in the fruit fly and the sea squirt, fungal genome evolution, mouse and rat mutagenesis, the future of crop plant genomics, how livestock genomics informs human medicine, the importance of the dog genome in studying human disease, and the search for “humanness” through human and chimp genome comparison. In addition, updates on emerging technologies in DNA sequencing and in gene prediction, as well as direction to relevant public resources, are given.

This book serves as a valuable reference and teaching tool for established scientists in the genomics field and as a comprehensive overview for those with more general interests in biology.



review:  “This collection of 20 chapters was originally published in a 2005 issue of the journal Genome Research to commemorate the 10th anniversary of its inception. With contributions spanning a diverse array of organisms from microbes to humans, leaders in the field describe their work and its relevance to our understanding of the structure and function of genomes in what is now known as the ‘postgenomic age.’ ... As we embrace a future of databases of hundreds of genomes, this volume is an exemplary treatment of how biological questions in comparative genomics should be portrayed.”
      —The Quarterly Review of Biology

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Foreword, J.D. Watson
1. Insights on Biology and Evolution from Microbial Genome Sequencing
2. Changing Perspectives in Yeast Research Nearly a Decade after the Genome Sequence
3. Genomics of the Fungal Kingdom: Insights into Eukaryotic Biology
4. The Arabidopsis Genome: A Foundation for Plant Research
5. Grains of Knowledge: Genomics of Model Cereals
6. Genomics in Caenorhabditis elegans: So Many Genes, Such a Little Worm
7. Drosophila melanogaster: A Case Study of a Model Genomic Sequence and Its Consequences
8. Unraveling Genomic Regulatory Networks in the Simple Chordate, Ciona intestinalis
9. Fish Genomics and Biology
10. Xenomics
11. Chicken Genome: Current Status and Future Opportunities
12. Advances in Livestock Genomics: Opening the Barn Door
13. The Canine Genome
14. Impact of Genomics on Research in the Rat
15. The Mouse Genome
16. Genomics of the Future: Identification of Quantitative Trait Loci in the Mouse
17. Comparing the Human and Chimpanzee Genomes: Searching for Needles in a Haystack
18. Structure and Function of the Human Genome
19. Emerging Technologies in DNA Sequencing
20. Genome Annotation Past, Present, and Future: How to Define an Open Reading Frame at Each Locus

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