© 2010 • 443 pp., illus., index
Hardcover • $135 27.00 • ISBN  978-0-879698-84-3
You save: 80%
You will receive free shipping on this item at checkout.
Free shipping offer applies to direct website purchases by individual U.S. and Canada customers only.

Cell-cell junctions are multi-molecular complexes that link neighboring cells. They help maintain tissue integrity, act as barriers to permeability, and allow intercellular transport. They also reinforce cell polarity by separating the apical and basolateral domains of the plasma membrane.

Written and edited by experts in the field, this collection from Cold Srping Harbor Perspectives in Biology includes contributions covering each of the main junction types

Preface

Historical Perspective

Discovering the Molecular Components of Intercellular Junctions—A Historical View

Werner W. Franke

 

Overview of Junction Organization

Molecular Basis of the Core Structure of Tight Junctions

Mikio Furuse

Adherens Junction: Molecular Architecture and Regulation

Wenxiang Meng and Masatoshi Takeichi

Gap Junctions

Daniel A. Goodenough and David L. Paul

The Desmosome

Emmanuella Delva, Dana K. Tucker, and Andrew P. Kowalczyk

 

Structural Organization of Junctions

Structure and Biochemistry of Cadherins and Catenins

Lawrence Shapiro and William I. Weis

Physiology and Function of the Tight Junction

James M. Anderson and Christina M. Van Itallie

 

Junction Dynamics and Assembly

Molecular Bases of Cell-Cell Junctions Stability and Dynamics

Matthieu Cavey and Thomas Lecuit

Intercellular Junction Assembly, Dynamics, and Homeostasis

Kathleen J. Green, Spiro Getsios, Sergey Troyanovsky, and L.M. Godsel

 

Junction Signaling

Adhesive and Signaling Functions of Cadherins and Catenins in Vertebrate Development

Ewa Stepniak, Glenn L. Radice, and Valeri Vasioukhin

Interplay of Cadherin-mediated Cell Adhesion and Canonical Wnt Signaling

Julian Heuberger and Walter Birchmeier

Wnt Signaling from Development to Disease: Insights from Model Systems

Ken M. Cadigan and Mark Peifer

Cadherin-mediated Intercellular Adhesion and Signaling Cascades Involving Small GTPases

Takashi Watanabe, Kazuhide Sato, and Kozo Kaibuchi

Junctional Music that the Nucleus Hears: Cell-Cell Contact Signaling and the Modulation of Gene Activity

Pierre D. McCrea, Dongmin Gu, and Maria S. Balda

 

Complex Junction Organization

Cell Adhesion, the Backbone of the Synapse: “Vertebrate” and “Invertebrate” Perspectives

Nikolaos Giagtzoglou, Cindy V. Ly, and Hugo J. Bellen

Modular Design of Immunological Synapses and Kinapses

Michael L. Dustin

Membrane Domains Based on Ankyrin and Spectrin Associated with Cell-Cell Interactions

Vann Bennett and Jane Healy

Planar Cell Polarity: Keeping Hairs Straight Is Not So Simple

Helen McNeill

 

Junctions as Targets for Disease

Listeria monocytogenes Internalin and E-cadherin: From Bench to Bedside

Matteo Bonazzi, Marc Lecuit, and Pascale Cossart

Cadherins as Targets for Genetic Diseases

Aziz El-Amraoui and Christine Petit

Involvement of Members of the Cadherin Superfamily in Cancer

Geert Berx and Frans van Roy

 

Index