© 2012 • 352 pp., illustrations, index
Hardcover • $135 • ISBN  978-1-936113-46-0

The synthesis of proteins by ribosomes is a fundamental cellular process. Cells must tightly control protein synthesis to maintain homeostasis and regulate proliferation, growth, differentiation, and development. Indeed, aberrant translational control is associated with cancer, several neurologic syndromes, and a group of genetic disorders termed “ribosomopathies.”

Written and edited by experts in the field, this collection from Cold Spring Harbor Perspectives in Biology covers our current understanding of all aspects of protein synthesis and its control. The contributors describe the fundamental steps in protein synthesis (initiation, elongation, and termination), the factors involved, and high-resolution structures of translational machinery where this takes place. They review the targets of translational control (e.g., initiation factors, mRNAs, and ribosomes) and how signaling pathways modulate this machinery. The roles of the endoplasmic reticulum, the unfolded protein response, processing bodies (P-bodies), stress granules, and small RNAs are also covered.

This volume includes discussion of translational deregulation in cancer and the development of therapeutic agents that target translation initiation. Thus, it is an essential reference for cell and molecular biologists, as well as cancer biologists and all those investigating human diseases associated with translation dysfunction.

Preface

Principles of Translational Control: An Overview

John W.B. Hershey, Nahum Sonenberg, and Michael B. Mathews

The Structure and Function of the Eukaryotic Ribosome

Daniel N. Wilson and Jamie H. Doudna Cate

The Mechanism of Eukaryotic Translation Initiation: New Insights and Challenges

Alan G. Hinnebusch and Jon R. Lorsch

The Elongation, Termination, and Recycling Phases of Translation in Eukaryotes

Thomas E. Dever and Rachel Green

Single-Molecule Analysis of Translational Dynamics

Alexey Petrov, Jin Chen, Seán O’Leary, Albert Tsai, and Joseph D. Puglisi

The Current Status of Vertebrate Cellular mRNA IRESs

Richard J. Jackson

From Cis-Regulatory Elements to Complex RNPs and Back

Fátima Gebauer, Thomas Preiss, and Matthias W. Hentze

Regulation of mRNATranslation by Signaling Pathways

Philippe P. Roux and Ivan Topisirovic

Protein Secretion and the Endoplasmic Reticulum

Adam M. Benham

New Insights into Translational Regulation in the Endoplasmic Reticulum Unfolded Protein Response

Graham D. Pavitt and David Ron

P-Bodies and Stress Granules: Possible Roles in the Control of Translation and mRNA Degradation

Carolyn J. Decker and Roy Parker

mRNA Localization and Translational Control in Drosophila Oogenesis

Paul Lasko

Toward a Genome-Wide Landscape of Translational Control

Ola Larsson, Bin Tian, and Nahum Sonenberg

Imaging Translation in Single Cells Using Fluorescent Microscopy

Jeffrey A. Chao, Young J. Yoon, and Robert H. Singer

A Molecular Link between miRISCs and Deadenylases Provides New Insight into the Mechanism of Gene Silencing by MicroRNAs

Joerg E. Braun, Eric Huntzinger, and Elisa Izaurralde

Translational Control in Cancer Etiology

Davide Ruggero

Cytoplasmic RNA-Binding Proteins and the Control of Complex Brain Function

Jennifer C. Darnell and Joel D. Richter

Tinkering with Translation: Protein Synthesis in Virus-Infected Cells

Derek Walsh, Michael B. Mathews, and Ian Mohr

Emerging Therapeutics Targeting mRNATranslation

Abba Malina, John R. Mills, and Jerry Pelletier

Index