© 2010 • 360 pp., illus. (48 color, 19 b/w), index
Trim size: 7” x 10”
Hardcover • $135 • ISBN  978-0-879698-30-0

The p53 Family front cover image courtesy of Andreas Joerger (see article by Andreas C. Joerger, and Alan R. Fersht).

The p53 tumor suppressor gene—the “guardian of the genome”—protects cells against genotoxic stress but is mutated in many cancers. It encodes one of a family of transcription factors (p53, p63, and p73) that regulate cell proliferation, differentiation, senescence, and cell death. Mutations in p53 allow cells to escape normal growth controls and thereby contribute to tumor malignancy.

Written and edited by experts in the field, this volume provides a comprehensive review of the functions of the p53 family. The contributors examine the normal roles of these transcription factors, the regulatory mechanisms that control p53 activity, and the part played by p53 mutations in tumorigenesis. They also discuss the evolution of the p53 family, which may originally have arisen to protect the integrity of the germ line.

This collection also covers the structure of p53 and its isoforms, model systems for analyzing p53 function, studies of p53 polymorphisms, and therapeutic approaches aimed at targeting p53 defects in cancer.

Preface

The Origins and Evolution of the p53 Family of Genes

Vladimir A. Belyi, Prashanth Ak, Elke Markert, Haijian Wang, Wenwei Hu, Anna Puzio-Kuter, and Arnold J. Levine

The Tumor Suppressor p53: From Structures to Drug Discovery

Andreas C. Joerger and Alan R. Fersht

The Isoforms of the p53 Protein

Marie P. Khoury and Jean-Christophe Bourdon

p63 and p73, the Ancestors of p53

Volker Dötsch, Francesca Bernassola, Daniel Coutandin, Eleonora Candi, and Gerry Melino

Transcriptional Regulation by p53

Rachel Beckerman and Carol Prives

Posttranslational Modification of p53: Cooperative Integrators of Function

David W. Meek and Carl W. Anderson

The Regulation of the p53-mediated Stress Response by MDM2 and MDM4

Mary Ellen Perry

Tied Up in Loops: Positive and Negative Autoregulation of p53

Xin Lu

TP53 Mutations in Human Cancers: Origins, Consequences, and Clinical Use

Magali Olivier, Monica Hollstein, and Pierre Hainaut

Clinical Outcomes and Correlates of TP53 Mutations and Cancer

Ana I. Robles and Curtis C. Harris

Single-nucleotide Polymorphisms in the p53 Signaling Pathway

Lukasz F. Grochola, Jorge Zeron-Medina, Sophie Mériaux, and Gareth L. Bond

Tumor Suppressive Functions of p53

Jack T. Zilfou and Scott W. Lowe

p53 Regulation of Metabolic Pathways

Eyal Gottlieb and Karen H. Vousden

p53 Regulation of the IGF-1/AKT/mTOR Pathways and the Endosomal Compartment

Zhaohui Feng

The Role of p53 Gene Family in Reproduction

Wenwei Hu

Using Mice to Examine p53 Functions in Cancer, Aging, and Longevity

Lawrence A. Donehower

Mutant p53 Gain-of-Function in Cancer

Moshe Oren and Varda Rotter

Mouse Models of p53 Functions

Guillermina Lozano

Zebrafish Models of p53 Functions

Narie Y. Storer and Leonard I. Zon

Phylogeny and Function of the Invertebrate p53 Superfamily

Rachael Rutkowski, Kay Hofmann, and Anton Gartner

p53-based Cancer Therapy

David P. Lane, Chit Fang Cheok, and Sonia Lain

Pathologies Associated with the p53 Response

Andrei V. Gudkov and Elena A. Komarova

P53 Research: The Past Thirty Years and the Next Thirty Years

David Lane and Arnold Levine

Index