© 2008 • 673 pp., illus, index
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The idea that the adult brain of mammals can generate new neurons has only recently been accepted by the scientific community, and research in this exciting area is now in full swing. Bringing together leading researchers in the field of adult neurogenesis, the 30 chapters in this monograph provide a valuable overview of this emerging field and lay the groundwork for future studies. Adult Neurogenesis includes discussions on neural stem cell biology; methods and models for studying adult neurogenesis; physiological and molecular processes and their control; related neurological diseases; and comparisons of neurogenesis in humans, birds, fish, and invertebrates. It will be of interest to all researchers in neurobiology as well as those in the medical field, as it has implications for understanding depression, epilepsy, and other psychiatric disorders.

  “The study of adult neurogenesis has grown exponentially over the past decade. New papers are being published almost daily, making any attempt to summarize the field a daunting task. Nevertheless, the editors and authors of Adult Neurogenesis have managed to assemble a comprehensive review of current research. Organized into seven sections that encompass 30 chapters covering topics ranging from the detection of adult-generated neurons to their possible role in neurological and psychiatric disease, the book provides a truly panoramic picture. The editors acknowledge that the volume presents only a ‘snapshot’ of the current field...but its comprehensive nature makes it a valuable collection of knowledge and ideas in this burgeoning area of neuroscience.”
      —Nature Neuroscience

  “Given the size of the literature on the subject of neurogenesis, it would be convenient to have most of the existing information compiled in an easily accessible form. Adult Neurogenesis by Gage, Kempermann, and Song is a recently published book that fills this niche by covering many aspects of this intriguing phenomenon....[T]he book is an authoritative source that provides wide coverage of the major topics of the field.”
      —Neuron

1. Adult Neurogenesis: A Prologue

F.H. Gage, H. Song, and G. Kempermann

METHODS

In vivo approaches

2. Numerology of Neurogenesis: Characterizing the Cell Cycle of Neurostem Cells

R.S. Nowakowski and N.L. Hayes

3. Detection and Phenotypic Characterization of Adult Neurogenesis

H.G. Kuhn and D.A. Peterson

4. Evolving Methods for the Labeling and Mutation of Postnatal Neuronal Precursor Cells: A Critical Review

J.J. Breunig, J. D. Macklis, and P.R. Rakic

5. The Use of Reporter Mouse Lines to Study Adult Neurogenesis

G. Enikolopov and L. Overstreet-Wadiche

6. Retrovirus-mediated Cell Labeling

C. Zhao

In vitro approaches

7. Neurospheres

I. Singec and A. Quiñones-Hinojosa

8. Monolayer Cultures of Neuronal Stem/Progenitor Cells

J. Ray

BASIC PROCESSES

9. Neurogenesis in the Adult Hippocampus

G. Kempermann, H. Song, and F.H. Gage

10. Adult Subventricular Zone and Olfactory Bulb Neurogenesis

D.A. Lim, Y.-C. Huang, and A. Alvarez-Buylla

11. Neurogenic Niches in the Adult Mammalian Brain

D.K. Ma, G.-l. Ming, F.H. Gage, and H. Song

MOLECULAR AND PHYSIOLOGICAL MECHANISMS

12. Adult Neurogenesis: Similarities and Differences in Stem Cell Fate, Proliferation, Migration, and Differentiation in Distinct Forebrain Regions

D.C. Lie and M. Götz

13. Proneuronal Genes Drive Neurogenesis on the Road from Development to Adulthood

E.T. Buchen and S.J. Pleasure

14. The Balance of Trophic Support and Cell Death in Adult Neurogenesis

H.G. Kuhn

15. Maturation and Functional Integration of New Granule Cells into the Adult Hippocampus

J. Bischofberger and A.F. Schinder

REGULATION

16. Genetics and Epigenetics in Adult Neurogenesis

J. Hsieh and J.W. Schneider

17. Activity Dependency and Aging in the Regulation of Adult Neurogenesis

G. Kempermann

18. Regulation of Hippocampal Neurogenesis by Systemic Factors Including Stress, Glucocorticoids, Sleep, and Inflammation

P.J. Lucassen, C.A. Oomen, A.-M. van Dam, and B. Czéh

19. Regulation of Adult Neurogenesis by Neurotransmitters

M.-H. Jang, H. Song, and G.-l Ming

FUNCTIONAL SIGNIFICANCE

20. Adult Neurogenesis in the Olfactory Bulb

P.-M. Lledo

21. Neurogenesis and Hippocampal Memory System

D.N. Abrous and J.M. Wojtowicz

22. Computational Modeling of Adult Neurogenesis

J.B. Aimone and L. Wiskott

NEUROLOGICAL DISEASES

23. Hippocampal Neurogenesis: Depression and Antidepressant Responses

A. Sahay, R. Hen, and R.S. Duman

24. Adult Neurogenesis in Neurodegenerative Diseases

P. Brundin, J. Winkler, and E. Masliah

25. Epilepsy and Adult Neurogenesis

S. Jessberger and J.M. Parent

26. Neurogenesis Following Stroke Affecting the Adult Brain

O. Lindvall and Z. Kokaia

COMPARATIVE NEUROGENESIS

27. Adult Neurogenesis in Teleost Fish

G.K.H. Zupanc

28. Neurogenesis in the Adult Songbird: A Model for Inducible Striatal Neuronal Addition

S.A. Goldman

29. Adult Human Neurogenesis: A Response to Cell Loss and New Circuitry Requirements

M.A. Curtis, P.S. Eriksson, and R.L.M. Faull

30. Adult Hippocampal Neurogenesis in Natural Populations of Mammals

I. Amrein, H.-P. Lipp, R. Boonstra, and J.M. Wojtowicz

Index