© 2011 • 499 pp., illus. (71 4C color images and 11 B&W images), index
Hardcover • $135 • ISBN  978-0-87969-903-1

Calcium ions play a critical role in signaling in a wide variety of cells and tissues, including muscle, immune cells, neurons, the liver, and oocytes. They can enter the cytoplasm from the extracellular environment or from intracellular stores and control the activity of numerous enzymes, other signaling molecules, transcription factors, and cytoskeletal components.

Written and edited by experts in the field, this volume explores the channels and pumps that transport calcium between different compartments and the regulation of calcium fluxes. The contributors discuss calcium buffers and sensors and how these produce distinct spatiotemporal calcium signals in different circumstances.

Including discussions of calcium signaling during development and normal physiology, as well as perturbed signaling in diseases such as diabetes, neurodegeneration, and atherosclerosis, the volume is an indispensable reference for biochemists, cell and developmental biologists, and physiologists seeking a comprehensive treatment of calcium biology.

Preface

 

CALCIUM SIGNAL GENERATION/MODULATION AND HOMEOSTASIS

 

Calcium Entry

Voltage-Gated Calcium Channels

William A. Catterall

The Role of Transient Receptor Potential Cation Channels in Ca²⁺ Signaling

Maarten Gees, Barbara Colsoul, and Bernd Nilius

Store-Operated Calcium Channels: New Perspectives on Mechanism and Function

Richard S. Lewis

mGluR1/TRPC3-Mediated Synaptic Transmission and Calcium Signaling in Mammalian Central Neurons

Jana Hartmann, Horst A. Henning, and Arthur Konnerth

 

Calcium Release

Ryanodine Receptors: Structure, Expression, Molecular Details, and Function in Calcium Release

Johanna T. Lanner, Dimitra K. Georgiou, Aditya D. Joshi, and Susan L. Hamilton

IP₃ Receptors: Toward Understanding Their Activation

Colin W. Taylor and Stephen C. Tovey

NAADP Receptors

Antony Galione

Calcium Oscillations

Geneviéve Dupont, Laurent Combettes, Gary S. Bird, and James W. Putney

 

Calcium Buffers and Pumps

Cytosolic Ca²⁺ Buffers

Beat Schwaller

Organellar Calcium Buffers

Daniel Prins and Marek Michalak

The Plasma Membrane Ca²⁺ ATPase and the Plasma Membrane Sodium Calcium Exchanger Cooperate in the Regulation of Cell Calcium

Marisa Brini and Ernesto Carafoli

The Ca²⁺ Pumps of the Endoplasmic Reticulum and Golgi Apparatus

Ilse Vandecaetsbeek, Peter Vangheluwe, Luc Raeymaekers, Frank Wuytack, and Jo Vanoevelen

 

FUNCTIONAL ASPECTS OF CALCIUM SIGNALING

 

Proteins Mediating Effects of Calcium

The Diversity of Calcium Sensor Proteins in the Regulation of Neuronal Function

Hannah V. McCue, Lee P. Haynes, and Robert D. Burgoyne

Regulation by Ca²⁺-Signaling Pathways of Adenylyl Cyclases

Michelle L. Halls and Dermot M.F. Cooper

Protein Kinase C: The “Masters” of Calcium and Lipid

Peter Lipp and Gregor Reither

 

Physiological Processes Regulated by Calcium

Ca²⁺ Signaling During Mammalian Fertilization: Requirements, Players, and Adaptations

Takuya Wakai, Veerle Vanderheyden, and Rafael A. Fissore

Calcium Signaling in Neuronal Development

Sheila S. Rosenberg and Nicholas C. Spitzer

Visualization of Ca²⁺ Signaling During Embryonic Skeletal Muscle Formation in Vertebrates

Sarah E. Webb and Andrew L. Miller

Calcium Signaling in Synapse-to-Nucleus Communication

Anna M. Hagenston and Hilmar Bading

Calcium Signaling in Cardiac Myocytes

Claire J. Fearnley, H. Llewelyn Roderick, and Martin D. Bootman

Calcium Signaling in Smooth Muscle

David C. Hill-Eubanks, Matthias E. Werner, Thomas J. Heppner, and Mark T. Nelson

 

Calcium in Cell Death and Disease

Apoptosis and Autophagy: Decoding Calcium Signals that Mediate Life or Death

Michael W. Harr and Clark W. Distelhorst

Endoplasmic-Reticulum Calcium Depletion and Disease

Djalila Mekahli, Geert Bultynck, Jan B. Parys, Humbert De Smedt, and Ludwig Missiaen

Index