© 2012 • 305 pp., illus., index
Hardcover • $135 • ISBN  978-1-936113-21-7

Discounts apply to direct purchases by individual U.S. and Canada customers only.

Type 1 diabetes, also known as juvenile-onset or insulin-dependent diabetes mellitus (IDDM), is caused by destruction of insulin-producing β cells in the pancreas by the body’s immune system. It affects hundreds of thousands of individuals worldwide, requiring regular insulin injections to control blood glucose levels and avoid severe consequences of glucose dysregulation. Written by experts in the field, this book provides a detailed examination of our understanding of the disease process and its causes, as well as genetic risk factors, animal models of diabetes, and new treatment strategies that are being developed.

Preface

The Pathogenesis and Natural History of Type 1 Diabetes

Mark A. Atkinson

Breakdown in Peripheral Tolerance in Type 1 Diabetes in Mice and Humans

Lukas T. Jeker, Hélène Bour-Jordan, and Jeffrey A. Bluestone

Generating β Cells from Stem Cells—The Story So Far

Matthias Hebrok

Endoplasmic Reticulum Stress, Pancreatic β-Cell Degeneration, and Diabetes

Feroz R. Papa

Genetics of Type 1 Diabetes

Janelle A. Noble and Henry A. Erlich

Humoral Autoimmunity in Type 1 Diabetes: Prediction, Significance, and Detection of Distinct Disease Subtypes

Massimo Pietropaolo, Roberto Towns, and George S. Eisenbarth

Immunologic and Metabolic Biomarkers of β-Cell Destruction in the Diagnosis of Type 1 Diabetes

Jasmin Lebastchi and Kevan C. Herold

Islet Autoantigens: Structure, Function, Localization, and Regulation

Peter Arvan, Massimo Pietropaolo, David Ostrov, and Christopher J. Rhodes

Do MHCII-Presented Neoantigens Drive Type 1 Diabetes and Other Autoimmune Diseases?

Philippa Marrack and John W. Kappler

Antigen Targets of Type 1 Diabetes Autoimmunity

Bart O. Roep and Mark Peakman

The Hygiene Hypothesis: An Explanation for the Increased Frequency of Insulin-Dependent Diabetes

Jean-François Bach and Lucienne Chatenoud

Environmental Triggers of Type 1 Diabetes

Mikael Knip and Olli Simell

Virus Infections in Type 1 Diabetes

Ken T. Coppieters, Tobias Boettler, and Matthias von Herrath

Connecting Type 1 and Type 2 Diabetes through Innate Immunity

Justin I. Odegaard and Ajay Chawla

Advancing Animal Models of Human Type 1 Diabetes by Engraftment of Functional Human Tissues in Immunodeficient Mice

Michael A. Brehm, Alvin C. Powers, Leonard D. Shultz, and Dale L. Greiner

Antigen-Specific Therapeutic Approaches in Type 1 Diabetes

Xavier Clemente-Casares, Sue Tsai, Carol Huang, and Pere Santamaria

Clinical Immunologic Interventions for the Treatment of Type 1 Diabetes

Lucienne Chatenoud, Katharina Warncke, and Anette-G. Ziegler

Update on Islet Transplantation

Michael McCall and A.M. James Shapiro

Index