© 2013 • 454 pp., illus. (75 4C and 6 B&W), index
Hardcover • $135 • ISBN  978-1-936113-23-1

Wnt proteins are signaling molecules that play critical roles during embryonic development and in the regeneration of adult tissues. They bind to Frizzled and LRP family receptors on the cell surface, triggering a series of events that cause

Preface

Three Decades of Wnts: A Personal Perspective on How a Scientific Field Developed

Roel Nusse and Harold Varmus

 

SECTION I: SIGNALING MECHANISMS

Wnt Proteins

Karl Willert and Roel Nusse

Secreted and Transmembrane Wnt Inhibitors and Activators

Cristina-Maria Cruciat and Christof Niehrs

Frizzled and LRP5/6 Receptors for Wnt/β-Catenin Signaling

Bryan T. MacDonald and Xi He

The β-Catenin Destruction Complex

Jennifer L. Stamos and William I. Weis

TCF/LEFs and Wnt Signaling in the Nucleus

Ken M. Cadigan and Marian L. Waterman

Alternative Wnt Pathways and Receptors

Renée van Amerongen

 

SECTION II: DEVELOPMENT

The Evolution of the Wnt Pathway

Thomas W. Holstein

Wnt/Wingless Signaling in Drosophila

Sharan Swarup and Esther M. Verheyen

β-Catenin-Dependent Wnt Signaling in C. elegans: Teaching an Old Dog a New Trick

Belinda M. Jackson and David M. Eisenmann

Wnt Signaling in Vertebrate Axis Specification

Hiroki Hikasa and Sergei Y. Sokol

Wnt Signaling in Mammalian Development: Lessons from Mouse Genetics

Jianbo Wang, Tanvi Sinha, and Anthony Wynshaw-Boris

 

SECTION III: STEM CELL BIOLOGY AND DIFFERENTIATION

Wnt Pathway Regulation of Embryonic Stem Cell Self-Renewal

Bradley J. Merrill

Wnt Signaling, Stem Cells, and Cancer of the Gastrointestinal Tract

Arnout Schepers and Hans Clevers

Wnt Signaling in Bone Development and Disease: Making Stronger Bone with Wnts

Jean B. Regard, Zhendong Zhong, Bart O. Williams, and Yingzi Yang

Wnt Signaling in the Vertebrate Central Nervous System: From Axon Guidance to Synaptic Function

Patricia C. Salinas

Wnt Signaling and Forebrain Development

Susan J. Harrison-Uy and Samuel J. Pleasure

Wnt Signaling in Normal and Malignant Hematopoiesis

William Lento, Kendra Congdon, Carlijn Voermans, Marcie Kritzik, and Tannishtha Reya

Wnt Signaling in Skin Development, Homeostasis, and Disease

Xinhong Lim and Roel Nusse

Wnt Signaling in Mammary Glands: Plastic Cell Fates and Combinatorial Signaling

Caroline M. Alexander, Shruti Goel, Saja A. Fakhraldeen, and Soyoung Kim

Wnt Signaling in Neuromuscular Junction Development

Kate Koles and Vivian Budnik

 

SECTION IV: DISEASE AND INTERVENTION

Wnt Signaling in Cancer

Paul Polakis

Wnt Signaling and Injury Repair

Jemima L. Whyte, Andrew A. Smith, and Jill A. Helms

Targeting Wnt Pathways in Disease

Zachary F. Zimmerman, Randall T. Moon, and Andy J. Chien

Index