© 2004 • 652 pp., illus., appendices, index
Hardcover • $139 27.80 • ISBN  978-087969672-6
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Recent breakthroughs in the field of cell growth, particularly in the control of cell size, are reviewed by experts in the three major divisions of the field: growth of individual cells, growth of organs, and regulation of cell growth in the contexts of development and cell division. This book is an introductory overview of the field and should be adaptable as a textbook.

  “Collectively, the different chapters cover a wide range of topics that will be of particular interest to cell, developmental and evolutionary biologists alike...The book’s multi–disciplinary nature will make it an excellent reference for many scientists. Cell Growth, like many titles from the Cold Spring Harbor monograph series, should stand the test of time and serve as a solid foundation for this ever–expanding field.”
      —Nature

  “The book begins with an excellent, although brief, foreword on the principles of cell–size regulation and a first chapter—How Metazoans Reach Their Full Size: The Natural History of Bigness—that discusses key concepts connecting cell growth to organism size. Together, they provide a pleasing intellectual framework for the entire book, and each chapter would also be appropriate as teaching material in a graduate student class. The rest of the book consists of chapters covering more specialized topics...
Cell Growth: Control of Cell Size is an authoritative and detailed book on growth regulation.”
      —Nature Cell Biology

  “The publication of this book coincides with the onset of a new era in growth studies, and it should be of great use for helping students and researchers appreciate growth as a regulated process playing key roles in many developmental, physiological, and pathological events.”
      —Developmental Cell

Preface

Foreword
P. Nurse

Chapter 1: How Metazoans Reach Their Full Size: The Natural History of Bigness
P.H. O'Farrell

Chapter 2: Growth and Cell Cycle Control in Drosophila
B.A. Edgar and H.F. Nijhout

Chapter 3: Coordination of Cell Growth and Cell–cycle Progression in Proliferating Mammalian Cells
I. Conlon, A. Lloyd, and M. Raff

Chapter 4: Coordination of Cell Growth and Cell Division
E.V. Schmidt

Chapter 5: TOR Signaling in Yeast: Temporal and Spatial Control of Cell Growth
R. Loewith and M.N. Hall

Chapter 6: Growth Regulation by Insulin and TOR Signaling in Drosophila
S.J. Leevers and E. Hafen

Chapter 7: Growth Control through the mTOR Network
D.A. Guertin, D.–H. Kim, and D.M. Sabatini

Chapter 8:IGF–I Receptor Signaling in Cell Growth and Proliferation
R. Baserga

Chapter 9: S6K Integrates Nutrient and Mitogen Signals to Control Cell Growth
J. Montagne and G. Thomas

Chapter 10: Translation Initiation and Cell Growth Control
E. Petroulakis and N. Sonenberg

Chapter 11: Forging the Factory: Ribosome Synthesis and Growth Control in Budding Yeast
P. Jorgensen, M. Tyers, and J.R. Warner

Chapter 12: Control of rRNA and tRNA Production Is Closely Tied to Cell Growth
R.J. White

Chapter 13: Autophagy: Reversing Cell Growth
Y. Ohsumi

Chapter 14: Synaptic Growth, Synaptic Maintenance, and the Persistence of Long–term Memory Storage
C.H. Bailey, R.D. Hawkins, and E.R. Kandel

Chapter 15: The Control of Synaptic Function by Local Protein Synthesis and Degradation
W.B. Smith, B. Bingol, G.N. Patrick, and E.M. Schuman

Chapter 16: Lymphocyte Growth
D.E. Bauer and C.B. Thompson

Chapter 17: Modulating Skeletal Muscle Hypertrophy and Atrophy: Signaling Pathways and Therapeutic Targets
D.J. Glass and G.D. Yancopoulos

Chapter 18: Mechanisms Controlling Heart Growth in Mammals
J.R. McMullen and S. Izumo

Chapter 19: Regulation of Cell Growth in the Endocrine Pancreas
K. Roovers and M.J. Birnbaum

Chapter 20: Plant Cell Growth
B. Menand and C. Robaglia

Index