© 2000 • 383 pp., illus., index
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The Laboratory that bears the Cold Spring Harbor name is famous for its research, its role in science education, and the science that won three recent Nobel prizes. This book, an intellectual history of Cold Spring Harbor Laboratory, can be enjoyed by anyone interested in the development of contemporary science, regardless of technical background. It is assembled on the foundation of twenty research papers published between 1903 and 1969. Now hard to track down, they are reproduced in facsimile and accompanied by a series of essays by Jan Witkowski describing the investigations that were done, who did them, and why they were important. This handsome volume will appeal to students, established scientists, and others intrigued not only by the history of research at Cold Spring Harbor but also by an extraordinary period in the flowering of American science.

  "This volume is a treat for both scientists and historians of science and it reflects well the love that Witkowski found in sifting through the laboratory's archives."
      —Trends in Cell Biology

  "If you are anywhere on the spectrum from frequent Cold Spring Harbor visitor to someone who barely knows that Symposia of that name were until recently published in maroon covers, and if you want to learn more of the history of this remarkable research centre, then this book is for you."
      —Journal of Cell Science

Foreword

Preface

Acknowledgments

Prologue: How the Laboratory Was Planted at Cold Spring Harbor and Why It Grew There

Ecology, Adaptation, and Evolution — Early Research at Cold Spring Harbor

Davenport C.B. 1903. The Animal Ecology of the Cold Spring Sand Spit, with Remarks on the Theory of Adaptation

The Early Applications of Mendel's Genetics to Human Beings

Davenport G.C. and Davenport C.B. 1907. Heredity of Eye-Color in Man

The Development of Hybrid Corn at Cold Spring Harbor

Shull G.H. 1908. The Composition of a Field of Maize
Shull G.H. 1909. A Pure-line Method in Corn Breeding

Chromosomal Changes and Heredity

Blakeslee A.F., Belling J., and Farnham M.E. 1920. Chromosomal Duplication and Mendelian Phenomena in Datura Mutants

Mouse Headquarters, Cold Spring Harbor

Little C.C. 1920. The Heredity of Susceptibility to a Transplantable Sarcoma (J.W.B.) of the Japanese Waltzing Mouse
Richter M.N. and MacDowell E.C. 1930. Studies on Leukemia in Mice: I: The Experimental Transmission of Leukemia

Unstable Genes in Drosophila

Demerec M. 1926. Reddish—A Frequently “Mutating” Character in Drosophila virilis

Quantitative Biology Comes to the Biological Laboratory-Isolating Hormones

Rowntree L.G., Greene C.H., Swingle W.W., and Pfiffner J.J. 1930. The Treatment of Patients with Addison's Disease with the “Cortical Hormone” of Swingle and Pfiffner

The Genetics of Taste and Smell

Blakeslee A.F. 1932. Genetics of Sensory Thresholds: Taste for Phenylthiocarbamide

Pigeons, Hormones, and Lactation

Riddle O., Bates R.W., and Dykshorn S.W. 1932. A New Hormone of the Anterior Pituitary

Quantitative Biology: Biophysics in the Biological Laboratory

Fricke H. and Curtis H.J. 1934. Electric Impedance of Suspensions of Yeast Cells

Broken Chromosomes

McClintock B. 1942. The Fusion of Broken Ends of Chromosomes following Nuclear Fusion

Penicillin: The Department of Genetics at War

Demerec M. 1948. Production of Penicillin. United States Patent
Demerec M. 1945. Development of a High-yielding Strain of Penicillium

The Unstable Genome-Movable Genes

McClintock B. 1951. Chromosome Organization and Genic Expression

Dissecting the Bacteriophage Life Cycle

Doermann A. 1952. The Intracellular Growth of Bacteriophages. I. Liberation of Intracellular T4 by Premature Lysis with Another Phage or with Cyanide

The Hershey-Chase Experiment

Hershey A. and Chase M. 1952. Independent Functions of Viral Protein and Nucleic Acid in Growth of Bacteriophage

Assembly Line Genes

Demerec M. and Hartman Z. 1956. Tryptophan Mutants in Salmonella typhimurium

First Glimpses of DNA Repair

Witkin E.M. 1956. Time, Temperature, and Protein Synthesis: A Study of Ultraviolet-induced Mutation in Bacteria

DNA and the T2 Phage Chromosome

Cairns J. 1961. An Estimate of the Length of the DNA Molecule of T2 Bacteriophage by Autoradiography

The Sticky Ends of Phage Lambda and Their Uses

Hershey A.D., Burgi E., and Ingraham L. 1963. Cohesion of DNA Molecules Isolated from Phage Lambda

DNA Synthesis and the Case of the Missing Enzyme

De Lucia P. and Cairns J. 1969. Isolation of an E. coli Strain with a Mutation Affecting DNA Polymerase

Appendices: Directors at Cold Spring Harbor

Charles B. Davenport

MacDowell E.C. 1946. Charles Benedict Davenport 1866–1944. A Study of Conflicting Influences

Reginald G. Harris

Anonymous. 1982. Reginald Harris and the Biological Laboratory

Milislav Demerec

Wallace B. 1971. Milislav Demerec 1895–1966

Name Index

Subject Index