© 2012 • 387 pp., illus. (62 4C and 5 B&W), index
Hardcover • $135 • ISBN  978-1-936113-38-5

In most tissues, cells are surrounded by an extracellular matrix (ECM) containing proteins such as collagen, laminin, and fibronectin. The ECM plays an important role in regulating cell function. ECM proteins bind to integrins and other cell surface receptors, activating signaling pathways that regulate cellular morphology, adhesion, cell migration, cell proliferation, and apoptosis.

Written and edited by experts in the field, this collection from Cold Srping Harbor Perspectives in Biology covers all aspects of ECM composition and function, as well as alterations in the ECM that occur during development, tumorigenesis, and other disease states. The contributors examine the various ECM proteins and proteoglycans, ECM receptors such as integrins, and the signaling pathways that mediate the effects of the ECM on cells. They also describe ECM functions in specific biological contexts, including angiogenesis, hemostasis, and thrombosis.

Covering not only the biochemistry and cell biology of the ECM but also its roles in development, physiology, and pathology, this volume is an indispensable reference for cell biologists and all those interested in exploring the myriad functions of the ECM.

Preface

Overview of the Matrisome—An Inventory of Extracellular Matrix Constituents and Functions

Richard O. Hynes and Alexandra Naba

Basement Membranes: Cell Scaffoldings and Signaling Platforms

Peter D. Yurchenco

The Collagen Family

Silvie Ricard-Blum

Heparan Sulfate Proteoglycans

Stephane Sarrazin, William C. Lamanna, and Jeffrey D. Esko

The Thrombospondins

Josephine C. Adams and Jack Lawler

Tenascins and the Importance of Adhesion Modulation

Ruth Chiquet-Ehrismann and Richard P. Tucker

Fibronectins, Their Fibrillogenesis and In Vivo Functions

Jean E. Schwarzbauer and Douglas W. DeSimone

Integrin Structure, Activation, and Interactions

Iain D. Campbell and Martin J. Humphries

Crosstalk Among TGFβ Signaling Pathways, Integrins, and the Extracellular Matrix

John S. Munger and Dean Sheppard

Molecular Architecture and Function of Matrix Adhesions

Benjamin Geiger and Kenneth M. Yamada

Genetic Analyses of Integrin Signaling

Sara A. Wickström, Korana Radovanac, and Reinhard Fässler

Integrins and Extracellular Matrix in Mechanotransduction

Martin Alexander Schwartz

Integrins in Cell Migration

Anna Huttenlocher and Alan Rick Horwitz

Extracellular Matrix Degradation and Remodeling in Development and Disease

Pengfei Lu, Ken Takai, Valerie M. Weaver, and Zena Werb

Extracellular Matrix in Development: Insights from Mechanisms Conserved between Invertebrates and Vertebrates

Nicholas H. Brown

Angiogenesis

Donald R. Senger and George E. Davis

Extracellular Matrix: Functions in the Nervous System

Claudia S. Barros, Santos J. Franco, and Ulrich Müller

Cell–Extracellular Matrix Interactions in Normal and Diseased Skin

Fiona M. Watt and Hironobu Fujiwara

Extracellular Matrix Proteins in Hemostasis and Thrombosis

Wolfgang Bergmeier and Richard O. Hynes

Index