© 2012 • 406 pp., illus. (36 4C images and 19 B&W), index
Hardcover • $135 • ISBN  978-1-936113-32-3

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First described as “the shaking palsy” in 1817 by James Parkinson, Parkinson’s disease is a disabling neurodegenerative disorder that is common among the elderly. It involves the gradual depletion of brain cells that control balance and movement, causing trembling, muscle rigidity, and difficulty walking. Characteristic brain changes — such as the formation of Lewy bodies and the degeneration of dopamine-producing neurons — have been identified, but diagnostic tests and therapeutic options remain limited.

Written and edited by experts in the field, this collection from Cold Spring Harbor Perspectives in Medicine includes contributions covering all aspects of Parkinson’s disease, from its neuropathological and clinical bases to the diagnostic challenges and therapeutic interventions. Contributors discuss the mutations in genes encoding proteins such as α-synuclein, parkin, and LRRK2 that cause Parkinson’s disease; the roles of mitochondria, autophagy, protein quality control, and programmed cell death in disease progression; and the chemistry and anatomy of the basal ganglia that are affected. The use of functional neuroimaging and experimental models to probe the neurobiology of Parkinson’s disease are also described.

Blending both the clinical and basic science of Parkinson’s disease, this volume is a vital reference for neurobiologists, cell biologists, and pathologists pursuing the biological basis of Parkinson’s disease, as well as scientists and clinicians interested in its diagnosis and treatment.

Preface

The History of Parkinson’s Disease: Early Clinical Descriptions and Neurological Therapies

Christopher G. Goetz

Clinical Approach to Parkinson’s Disease: Features, Diagnosis, and Principles of Management

João Massano and Kailash P. Bhatia

Parkinson’s Disease and Parkinsonism: Neuropathology

Dennis W. Dickson

Genetics of Parkinson’s Disease

Christine Klein and Ana Westenberger

α-Synuclein in Parkinson’s Disease

Leonidas Stefanis

Leucine-Rich Repeat Kinase 2 for Beginners: Six Key Questions

Lauren R. Kett and William T. Dauer

Parkinsonism Due to Mutations in PINK1, Parkin, and DJ-1 and Oxidative Stress and Mitochondrial Pathways

Mark R. Cookson

Genomics and Bioinformatics of Parkinson’s Disease

Sonja W. Scholz, Tim Mhyre, Habtom Ressom, Salim Shah, and Howard J. Federoff

Parkinson’s Disease: Gene Therapies

Philippe G. Coune, Bernard L. Schneider, and Patrick Aebischer

Functional Neuroanatomy of the Basal Ganglia

José L. Lanciego, Natasha Luquin, and José A. Obeso

Functional Neuroimaging in Parkinson’s Disease

Martin Niethammer, Andrew Feigin, and David Eidelberg

Motor Control Abnormalities in Parkinson’s Disease

Pietro Mazzoni, Britne Shabbott, and Juan Camilo Cortés

Physiological Phenotype and Vulnerability in Parkinson’s Disease

D. James Surmeier, Jaime N. Guzman, Javier Sanchez, and Paul T. Schumacker

Modeling Parkinson’s Disease in Primates: The MPTP Model

Gregory Porras, Qin Li, and Erwan Bezard

A Guide to Neurotoxic Animal Models of Parkinson’s Disease

Kim Tieu

Animal Models of Parkinson’s Disease: Vertebrate Genetics

Yunjong Lee, Valina L. Dawson, and Ted M. Dawson

Drosophila as a Model to Study Mitochondrial Dysfunction in Parkinson’s Disease

Ming Guo

Mitochondrial Biology and Parkinson’s Disease

Celine Perier and Miquel Vila

The Role of Autophagy in Parkinson’s Disease

Melinda A. Lynch-Day, Kai Mao, Ke Wang, Mantong Zhao, and Daniel J. Klionsky

Disruption of Protein Quality Control in Parkinson’s Disease

Casey Cook, Caroline Stetler, and Leonard Petrucelli

Programmed Cell Death in Parkinson’s Disease

Katerina Venderova and David S. Park

Innate Inflammation in Parkinson’s Disease

V. Hugh Perry

Inflammation and Adaptive Immunity in Parkinson’s Disease

R. Lee Mosely, Jessica A. Hutter-Saunders, David K. Stone, and Howard E. Gendelman

Index