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Introduction to Protein-DNA Interactions: Structure, Thermodynamics, and Bioinformatics


Subject Area(s):  BioinformaticsProteins and ProteomicsMolecular BiologyBiochemistry

By Gary D. Stormo, Ph.D.

View an excerpt from the book here



© 2013 • 208 pp., illus. (78 4C, 5 B&W), index
Paperback • $45 (click here to price in UK Pounds)
ISBN  978-1-936113-50-7

This title also available in: Hardcover

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Description

One of the foundations of molecular biology is how the interactions of proteins with DNA control many aspects of gene expression. Since the mid-20th century, from discoveries of the lac repressor and operator and the competition between the cI and cro proteins for the same segment of DNA, we have learned an enormous amount about the interactions of proteins with DNA and their control of fundamental processes in the cell. Introduction to Protein–DNA Interactions: Structure, Thermodynamics, and Bioinformatics describes what we know about protein–DNA interactions from the complementary perspectives of molecular and structural biology and bioinformatics and how each perspective informs the others. A particular emphasis is on how insights from experimental work can be translated into specific computational approaches to create a unified view of the field and a fuller understanding of protein–DNA interactions.

Figs 3-4, 3-5, 3-6, 3-7, and 3-8 from Chapter 3

Click on the small images for a larger view.

Introduction to Protein–DNA Interactions figure:4 thumbnail image
Figure: 3-4

Introduction to Protein–DNA Interactions figure:4 thumbnail image
Figure: 3-5

Introduction to Protein–DNA Interactions figure:4 thumbnail image
Figure: 3-6

Introduction to Protein–DNA Interactions figure:4 thumbnail image
Figure: 3-7

Introduction to Protein–DNA Interactions figure:4 thumbnail image
Figure: 3-8

©2012 Cold Spring Harbor Laboratory Press

Contents

Preface
 
1 Importance of Protein–DNA Interactions
 
STRUCTURE
 
2 The Structure of DNA
3 Protein Structure and DNA Recognition
4 Sequence-Specific Interactions in Protein–DNA Complexes
 
THERMODYNAMICS
 
5 Binding Affinity, Cooperativity, and Specificity
6 Energetics and Kinetics of Binding
 
BIOINFORMATICS
 
7 Bioinformatics of DNA-Binding Sites
8 Bioinformatics of Transcription Factors and Recognition Models
9 Transcriptional Genomics
 
Index
 

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