© 2013 • 336 pp., illus (61 4C, 9 B&W), index
Hardcover • $135 • ISBN  978-1-936113-82-8

The endoplasmic reticulum (ER) is an extensive network of membranes that folds, modifies, and transports proteins in eukaryotic cells. It also manufactures lipids and interacts extensively with other organelles, playing essential roles in cell growth and homeostasis.

Written and edited by experts in the field, this collection from Cold Spring Harbor Perspectives in Biology covers all aspects of ER morphology and function, as well as its interactions with the nucleus, Golgi, and mitochondria. Contributors examine how proteins translocate across the ER membrane, the processes that occur inside the ER lumen (e.g., folding, glycosylation, and disulfide bond formation), and how the proteins are packaged into vesicles and transported to the Golgi. They also review quality-control mechanisms that are employed by the ER to detect and eliminate misfolded or unassembled proteins. Lipid synthesis and transport are also discussed.

This volume covers not only the biochemistry and cell biology of the ER, but also ER stress, metabolism, and the role of the ER in viral replication. Thus, it is an essential reference for cell biologists, physiologists, and pathologists interested in understanding the numerous functions of the ER.

Preface

Endoplasmic Reticulum Stress Sensing in the Unfolded Protein Response

Brooke M. Gardner, David Pincus, Katja Gotthardt, Ciara M. Gallagher, and Peter Walter

Protein Folding Homeostasis in the Endoplasmic Reticulum and Nutritional Regulation

David Ron and Heather P. Harding

The Mammalian ERAD System

James A. Olzmann, Ron R. Kopito, and John C. Christianson

The ERAD Pathways of Budding Yeast

Guillaume Thibault and Davis T.W. Ng

Protein Folding in the Endoplasmic Reticulum

Ineke Braakman and Daniel N. Hebert

Disulfide Bond Formation in the Mammalian Endoplasmic Reticulum

Neil J. Bulleid

Endoplasmic Reticulum Structure and Interconnections with Organelles

Amber R. English and Gia K. Voeltz

Lipid Transport between the Endoplasmic Reticulum and Mitochondria

Vid V. Flis and Günther Daum

The Role of the Endoplasmic Reticulum in Peroxisome Biogenesis

Lazar Dimitrov, Sheung Kwan Lam, and Randy Schekman

How Viruses Use the Endoplasmic Reticulum for Entry, Replication, and Assembly

Takamasa Inoue and Billy Tsai

The Contribution of Systematic Approaches to Characterizing the Proteins and Functions of the Endoplasmic Reticulum

Maya Schuldiner and Jonathan S. Weissman

Cell Biology of the ER and the Golgi Apparatus through Proteomics

Jeffrey Smirle, Catherine E. Au, Michael Jain, Kurt Dejgaard, Tommy Nilsson, and John J. Bergeron

Nonvesicular Lipid Transfer from the Endoplasmic Reticulum

Sima Lev

Sphingolipid Homeostasis in the Endoplasmic Reticulum and Beyond

David K. Breslow

ER Targeting and Insertion of Tail-Anchored Membrane Proteins by the GET Pathway

Vladimir Denic, Volker Dötsch, and Irmgard Sinning

Protein Translocation across the Rough Endoplasmic Reticulum

Elisabet C. Mandon, Steven F. Truemen, and Reid Gilmore

N-linked Protein Glycosylation in the Endoplasmic Reticulum

Jörg Breitling and Markus Aebi

The Highly Conserved COPII Coat Complex Sorts Cargo from the ER and Targets it to the Golgi

Christopher Lord, Susan Ferro-Novick, and Elizabeth A. Miller

Functional Insights from Studies on the Structure of the Nuclear Pore and Coat Protein Complexes

Thomas Schwartz

Expanding Proteostasis by Membrane Trafficking Networks

Darren M. Hutt and William E. Balch

Retrograde Traffic from the Golgi to the Endoplasmic Reticulum

Anne Spang

Index