© 2013 • 576 pp., illus. (88 4C, 33 B&W), appendices, index
Hardcover • $135 • ISBN  978-1-936113-48-4

DNA replication is essential for the propagation of life on Earth. Cells in living organisms must be able to synthesize a complete copy of their DNA with extraordinary precision, so that they can pass this genetic material on to their descendants. DNA replication involves the coordinated interplay and regulation of many complex protein assemblies during the various stages of cell division. When these processes go awry, cancer and other diseases can ensue.

Written and edited by experts in the field, this volume covers all aspects of DNA replication and its control across all domains of life. The contributors examine the molecular machinery involved in the assembly of replication origin complexes, the establishment of replication forks, unzipping of the double helix, priming of DNA synthesis, and elongation of daughter strands. Chromatin organization and dynamics, lagging-strand maturation, telomere replication, and mechanisms to handle errors and damage in DNA are also discussed.

Including examination of the complex interactions between the core replication machinery and the regulatory circuits that drive cell cycle progression, this volume is an indispensable reference for not only biochemists and molecular biologists, but also cell biologists and all who want to understand this fundamental process of life.

Preface

Dedication to Arthur Kornberg

In Memoriam

Principles and Concepts of DNA Replication in Bacteria, Archaea, and Eukarya

Michael O’Donnell, Lance Langston, and Bruce Stillman

DNA Replication Origins

Alan C. Leonard and Marcel Méchali

Dormant Replication Origins

Debbie Mcintosh and J. Julian Blow

Break-Induced DNA Replication

Ranjith P. Anand, Susan T. Lovett, and James E. Haber

Helicase Loading at Chromosomal Origins of Replication

Stephen P. Bell and Jon M. Kaguni

Helicase Activation and Establishment of Replication Forks at Chromosomal Origins of Replication

Seiji Tanaka and Hiroyuki Araki

The Minichromosome Maintenance Replicative Helicase

Stephen D. Bell and Michael R. Botchan

Spatial and Temporal Organization of DNA Replication in Bacteria and Eukarya

Dean Jackson, Xindan Wang, and David Z. Rudner

DNA Replication Timing

Nicholas Rhind and David M. Gilbert

Replication-Fork Dynamics

Karl E. Duderstadt, Rodrigo Reyes-Lamothe, Antoine M. van Oijen, and David J. Sherratt

Replication Clamps and Clamp Loaders

Mark Hedglin, Ravindra Kumar, and Stephen J. Benkovic

Okazaki Fragment Metabolism

Lata Balakrishnan and Robert A. Bambara

Chromatin and DNA Replication

David M. MacAlpine and Geneviève Almouzni

Sister Chromatid Cohesion

Jan-Michael Peters and Tomoko Nishiyama

Replicative DNA Polymerases

Erik Johansson and Nicholas Dixon

Translesion DNA Polymerases

Myron F. Goodman and Roger Woodgate

Rescuing Stalled or Damaged Replication Forks

Joseph T.P. Yeeles, Jérôme Poli, Kenneth J. Marians, and Philippe Pasero

Replication of Telomeres and the Regulation of Telomerase

Verena Pfeiffer and Joachim Lingner

Genomic Instability in Cancer

Tarek Abbas, Mignon A. Keaton, and Anindya Dutta

Replication Proteins and Human Disease

Andrew P. Jackson, Ronald A. Laskey, and Nicholas Coleman

Regulating DNA Replication in Bacteria

Kirsten Skarstad and Tsutomu Katayama

Regulating DNA Replication in Eukarya

Khalid Siddiqui, Kin Fan On, and John F.X. Diffley

Regulating DNA Replication in Plants

Maria de la Paz Sanchez, Celina Costas, Joana Sequeira-Mendes, and Crisanto Gutierrez

Endoreplication

Norman Zielke, Bruce A. Edgar, and Melvin L. DePamphilis

Archaeology of Eukaryotic DNA Replication

Kira S. Makarova and Eugene V. Koonin

Human Mitochondrial DNA Replication

Ian J. Holt and Aurelio Reyes

Parvovirus Diversity and DNA Damage Responses

Susan F. Cotmore and Peter Tattersall

Human Papillomavirus Infections: Warts or Cancer?

Louise T. Chow and Thomas R. Broker

Adenovirus DNA Replication

Rob C. Hoeben and Taco G. Uil

Herpes Simplex Virus DNA Replication

Sandra K. Weller and Donald M. Coen

Epstein-Barr Virus DNA Replication

Wolfgang Hammerschmidt and Bill Sugden

Poxvirus DNA Replication

Bernard Moss

Appendix

Table 1. Databases for identification of genes in different organisms

Table 2. Style conventions for gene and protein nomenclature

Table 3. Nomenclature for proteins and protein complexes in different organisms

Index