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RNA: Life's Indispensable Molecule

By James Darnell, The Rockefeller University

© 2011 • 416 pp., illus., appendix, index
Hardcover • $40.00 • ISBN 978-1-936113-19-4

In RNA: Life’s Indispensable Molecule, Jim Darnell provides a comprehensive and captivating account of RNA research, illuminated by his own life-long and celebrated engagement in the field. Darnell describes how scientists unraveled fundamental questions about the biochemical and genetic importance of RNA—how mRNAs are generated and used to produce proteins, how noncoding and catalytic RNAs mediate key cellular processes, and how RNA molecules likely initiated life on Earth. With a scope extending from the early 20th century to the present day, and with the clarity expected from an accomplished textbook author, he conveys the intellectual context in which these questions first arose and explains how the key experiments were structured and answers obtained. The book is geared towards scientists from the graduate level on up, and will particularly appeal to active investigators in RNA biology, educators of molecular biology and biochemistry, and science historians.

About the Author

James E. Darnell, Jr., M.D. has been Vincent Astor Professor at The Rockefeller University since 1974. His career has included poliovirus research with Harry Eagle at the National Institutes of Health, research with François Jacob at the Pasteur Institute in Paris, and academic appointments at the Massachusetts Institute of Technology, Albert Einstein College of Medicine, and Columbia University. He has mentored over 120 doctoral students and postdoctoral scientists. From the very beginning of his first lab at MIT, Darnell, his students and postdocs have studied RNA, its synthesis, processing, and transcriptional regulation.

Darnell is a member of the National Academy of Sciences and has received numerous awards, including the 2003 National Medal of Science and the 2002 Albert Lasker Award for Special Achievement in Medical Science. He is the coauthor, with S.E. Luria, of General Virology (Wiley) and the founding author with Harvey Lodish and David Baltimore of Molecular Cell Biology

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Auxin Signaling: From Synthesis to Systems Biology

Edited By Mark Estelle, University of California, San Diego; Dolf Weijers, Wageningen University, The Netherlands; Karin Ljung, Umeå Plant Science Centre, Umeå, Sweden; Ottoline Leyser, University of York, United Kingdom

© 2011 • 253 pp., illus. (36 color, 13 b/w), index
Trim size: 7” x 10”
Hardcover • $135 $33.75 • ISBN 978-0-879698-98-0

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RNA Worlds: From Life’s Origins to Diversity in Gene Regulation

Edited By John F. Atkins, University of Utah, University College Cork, and Trinity College Dublin; Raymond F. Gesteland, University of Utah; Thomas R. Cech, Howard Hughes Medical Institute, University of Colorado

© 2011 • 366 pp., illus. (73 color, 23 b/w), index
Trim size: 8-1/2” x 10-7/8”
Hardcover • $162.00 • ISBN 978-0-879699-46-8

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The Origins of Life

Edited By David Deamer, University of California, Santa Cruz; Jack W. Szostak, Howard Hughes Medical Institute, Massachusetts General Hospital

© 2010 • 318 pp., illus. (47 color, 50 b/w), index
Trim size: 7” x 10”
Hardcover • $135 $33.75 • ISBN 978-1-936113-04-0

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Live Cell Imaging: A Laboratory Manual, Second Edition

Edited By Robert D. Goldman, Feinberg School of Medicine Northwestern University; Jason R. Swedlow, The University of Dundee; David L. Spector, Cold Spring Harbor Laboratory

© 2010 • 736 pp., illus., appendix, index
Paperback • $169.00 $118.30 • ISBN 978-0-879698-93-5

The second edition of Live Cell Imaging: A Laboratory Manual expands upon and extends the collection of established and evolving methods for studying dynamic changes in living cells and organisms presented in the well-known first edition. There are 16 new chapters and the 21 updated chapters in this new edition. They include advances in atomic force microscopy, structured illumination microscopy and other 3-D approaches, as well as imaging in single cells in animals and in plants. New analytical options include live high-throughput/high-content screening in mammalian cells and computational analysis of live cell data. The manual presents hands-on techniques as well as background material, and can serve as a text in advanced courses. The first section covers principles and fundamental issues of detection and imaging; the second provides detailed protocols for imaging live systems.

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Live Cell Imaging: A Laboratory Manual, Second Edition

Edited By Robert D. Goldman, Feinberg School of Medicine Northwestern University; Jason R. Swedlow, The University of Dundee; David L. Spector, Cold Spring Harbor Laboratory

© 2010 • 736 pp., illus., appendix, index
Hardcover • $246.00 $172.20 • ISBN 978-0-879698-92-8

The second edition of Live Cell Imaging: A Laboratory Manual expands upon and extends the collection of established and evolving methods for studying dynamic changes in living cells and organisms presented in the well-known first edition. There are 16 new chapters and the 21 updated chapters in this new edition. They include advances in atomic force microscopy, structured illumination microscopy and other 3-D approaches, as well as imaging in single cells in animals and in plants. New analytical options include live high-throughput/high-content screening in mammalian cells and computational analysis of live cell data. The manual presents hands-on techniques as well as background material, and can serve as a text in advanced courses. The first section covers principles and fundamental issues of detection and imaging; the second provides detailed protocols for imaging live systems.

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Untangling the Double Helix
DNA Entanglement and the Action of the DNA Topoisomerases

By James C. Wang, Harvard University

© 2009 • 233 pp., illus., appendices, index
Paperback • $46.00 • ISBN 978-087969879-9

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Untangling the Double Helix
DNA Entanglement and the Action of the DNA Topoisomerases

By James C. Wang, Harvard University

© 2009 • 233 pp., illus., appendices, index
Hardcover • $81.00 • ISBN 978-087969863-8

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Transcriptional Regulation in Eukaryotes: Concepts, Strategies, and Techniques, Second Edition

By Michael F. Carey, University of California, Los Angeles; Craig L. Peterson, University of Massachusetts Medical School, Worcester; Stephen T. Smale, University of California, Los Angeles

© 2009 • 620 pp., appendix, index
Paperback • $169.00 • ISBN 978-087969762-4

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Transcriptional Regulation in Eukaryotes: Concepts, Strategies, and Techniques, Second Edition

By Michael F. Carey, University of California, Los Angeles; Craig L. Peterson, University of Massachusetts Medical School, Worcester; Stephen T. Smale, University of California, Los Angeles

© 2009 • 620 pp., appendix, index
Hardcover • $246.00 • ISBN 978-087969777-8