Cold Spring Harbor Lab Press Molecular Biology

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Molecular Biology


More INFO on this Product	DNA Replication and Human Disease (Cold Spring Harbor Monograph Series 47) Edited By Melvin L. DePamphilis, National Institutes of Health © 2006 • 814 pp., illus., appendices, index Hardcover • ~~$139~~ $34.75 • ISBN 978-087969766-2

More INFO on this Product	Telomeres, Second Edition (Cold Spring Harbor Monograph Series 45) Edited By Titia de Lange, The Rockefeller University; Vicki Lundblad, The Salk Institute for Biological Sciences; Elizabeth Blackburn, University of California, San Francisco © 2006 • 576 pp., illus., index Paperback • ~~$49~~ $9.80 • ISBN 978-087969810-2 xAn up–to–date survey of the current exciting state of telomere biology. Telomeres—specialized structures found at the ends of chromosomes— are essential for maintaining the integrity of chromosomes and their faithful duplication during cell division. Chapters in this volume cover telomere structure and function in a range of organisms, focusing on how they are maintained, their roles in cell division and gene expression, and how deficiencies in these structures contribute to cancers and other diseases and even aging.y

More INFO on this Product	Telomeres, Second Edition (Cold Spring Harbor Monograph Series 45) Edited By Titia de Lange, The Rockefeller University; Vicki Lundblad, The Salk Institute for Biological Sciences; Elizabeth Blackburn, University of California, San Francisco © 2006 • 576 pp., illus., index Hardcover • ~~$139~~ $27.80 • ISBN 978-087969734-1 xAn up–to–date survey of the current exciting state of telomere biology. Telomeres—specialized structures found at the ends of chromosomes— are essential for maintaining the integrity of chromosomes and their faithful duplication during cell division. Chapters in this volume cover telomere structure and function in a range of organisms, focusing on how they are maintained, their roles in cell division and gene expression, and how deficiencies in these structures contribute to cancers and other diseases and even aging.y

More INFO on this Product	Landmark Papers in Yeast Biology Edited By Patrick Linder, University of Geneva; David Shore, University of Geneva; Michael N. Hall, Biozentrum, University of Basel © 2006 • 306 pp., index, CD Printed hardcover • ~~$99~~ $24.75 • ISBN 978-087969643-6 xYeast has been a preeminent experimental organism of genetic research for more than 50 years. Progress in the field has provided the conceptual framework that has driven experiments in many areas of biology. Landmark Papers in Yeast Biology consists of essays by prominent scientists on the context and significance of 71 carefully selected research papers, which are reprinted on the accompanying CD. The papers include early, hard–to–find classics as well as more recent advances in areas such as signal transduction, membrane trafficking, protein turnover, and genomics. This collection has unique value for all scholars of yeast and could provide the foundation for a literature–based course on molecular cell biology. As Jasper Rine notes in his eloquent introduction, the editors and contributors share the belief that “deep study of the agreed–on classics is the best training for learning how to recognize those contemporary papers worthy of our personal time....”y

More INFO on this Product	The Inside Story: DNA to RNA to Protein Edited By Jan Witkowski, Cold Spring Harbor Laboratory © 2005 • 382 pp., illus., index Paperback • ~~$29~~ $14.50 • ISBN 978-087969750-1

More INFO on this Product	Epigenetics (Cold Spring Harbor Symposia on Quantitative Biology LXIX) Edited By Bruce Stillman, Cold Spring Harbor Laboratory; David Stewart, Cold Spring Harbor Laboratory © 2004 • 532 pp., illus., index (Paperback edition does not include online access) Paperback • ~~$126~~ $63.00 • ISBN 978-087969731-0 xThe importance of epigenetic regulation of gene expression, particularly in higher organisms, is now clear and the 2004 Cold Spring Harbor Annual Symposium provided many new examples as well as insights into the underlying mechanisms. The resulting volume—with over 60 papers from experts across the field—covers various aspects of nuclear organization and dynamics; genomic imprinting, chromosomal inactivation, and other examples of gene silencing; the histone and DNA modifications associated with these conditions; and the roles of RNA and protein regulators in establishing and maintaining these states.y

More INFO on this Product	Epigenetics (Cold Spring Harbor Symposia on Quantitative Biology LXIX) Edited By Bruce Stillman, Cold Spring Harbor Laboratory; David Stewart, Cold Spring Harbor Laboratory © 2004 • 532 pp., illus., index (Hardcover edition includes online access; call for information and registration) Hardcover • ~~$310~~ $77.50 • ISBN 978-087969729-7 xThe importance of epigenetic regulation of gene expression, particularly in higher organisms, is now clear and the 2004 Cold Spring Harbor Annual Symposium provided many new examples as well as insights into the underlying mechanisms. The resulting volume—with over 60 papers from experts across the field—covers various aspects of nuclear organization and dynamics; genomic imprinting, chromosomal inactivation, and other examples of gene silencing; the histone and DNA modifications associated with these conditions; and the roles of RNA and protein regulators in establishing and maintaining these states.y

More INFO on this Product	A Genetic Switch, Third Edition, Phage Lambda Revisited By Mark Ptashne, Sloan-Kettering Memorial Cancer Center, New York © 2004 • 154 pp., illus., appendices, index Paperback • $40.00 • ISBN 978-087969716-7 xThe first edition of Mark Ptashne's 1986 book describing the principles of gene regulation in phage lambda became a classic in both content and form, setting a standard of clarity and precise prose that has rarely been bettered. This edition is a reprint of the original text, together with a new chapter updating the story to 2004. Among the striking new developments are recent findings on long–range interactions between proteins bound to widely separated sites on the phage genome, and a detailed description of how gene activation works. y

More INFO on this Product	DNA Interactive DVD Produced By Dolan DNA Learning Center, CSHL in collaboration with Red Green & Blue Company Ltd. Film footage by Windfall Films Ltd. © 2003 • DVD disc (NTSC version—unencoded), 4 hours (approx.) of viewing DVD • $33.00 • ISBN 978-097105881-1

More INFO on this Product	RNAi: A Guide to Gene Silencing Edited By Gregory J. Hannon, Cold Spring Harbor Laboratory © 2003 • 436 pp., illus., index Paperback • ~~$75~~ $15.00 • ISBN 978-087969704-4 xThe ability of double stranded RNA to inhibit the expression of genes with an appropriate sequence can be harnessed to silence target genes in vitro in a new and powerful way. This volume combines reliable RNAi protocols for a variety of species with discussion of strategies for the effective design of experiments using this important new technique that is changing the way experimental science is done. y

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