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Mammalian Development: Networks, Switches, and Morphogenetic Processes

Edited By Patrick P.L. Tam, Children’s Medical Research Institute; W. James Nelson, Stanford University; Janet Rossant, The Hospital for Sick Children

© 2013 • 520 pp., illus. (120 4C, 21 B&W), index
Hardcover • $155 • ISBN 978-1-936113-24-8

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The Mammary Gland as an Experimental Model

Edited By Mina J. Bissell, Lawrence Berkeley National Laboratory; Kornelia Polyak, Harvard Medical School; Jeffrey M. Rosen, Baylor College of Medicine

© 2011 • 325 pp., illus. (54 color, 5 b/w), index
Hardcover • $135 • ISBN 978-0-879699-06-2

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Manipulating the Mouse Embryo: A Laboratory Manual (Third Edition)

By Andras Nagy, Samuel Lunenfeld Research Institute; Marina Gertsenstein, Samuel Lunenfeld Research Institute; Kristina Vintersten, European Molecular Biology Laboratory; Richard Behringer, University of Texas M.D. Anderson Cancer Center

© 2003 • 764 pp., illus., appendices, index
Paperback • $169.00 • ISBN 978-087969591-0

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Max Perutz and the Secret of Life

By Georgina Ferry

© 2007 • 352 pp., illus., glossary, index
All orders from outside of the United States, Europe, and China must be directed to Chatto and Windus, an imprint of Random House at www.randomhouse.co.uk/chatto/

Don’t miss the new podcast and online slideshow featuring Georgina Ferry discussing her book and Max Perutz.

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Means to an End: Apoptosis and Other Cell Death Mechanisms

By Douglas R. Green, St. Jude Children’s Research Hospital

© 2011 • 220 pp., additional reading, index
Hardcover • $81.00 • ISBN 978-0-879698-87-4

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Means to an End: Apoptosis and Other Cell Death Mechanisms

By Douglas R. Green, St. Jude Children’s Research Hospital

© 2011 • 220 pp., additional reading, index
Paperback • $46.00 • ISBN 978-0-879698-88-1

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Mendel's Legacy: The Origin of Classical Genetics

By Elof Axel Carlson, Professor Emeritus, State University of New York at Stony Brook

© 2004 • 332 pp., illus., index
Hardcover • $47 $23.50 • ISBN 978-087969675-7

This latest book by Elof Carlson (The Unfit) is a first history of classical genetics, the era in which the chromosome theory of heredity was proposed and developed. Highly illustrated and based heavily on early 20th century original sources, the book traces the roots of genetics in breeding analysis and studies of cytology, evolution, and reproductive biology that began in Europe but were synthesized in the United States through new Ph.D. programs and expanded academic funding. Carlson argues that, influenced largely by new technologies and instrumentation, the life sciences progressed though incremental change rather than paradigm shifts, and he describes how molecular biology emerged from the key ideas and model systems of classical genetics. Readable and original, this narrative will interest historians and science educators as well as today's practitioners of genetics.

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Metabolism and Disease

Edited By Terri Grodzicker, Cold Spring Harbor Laboratory; Bruce Stillman, Cold Spring Harbor Laboratory; David Stewart, Cold Spring Harbor Laboratory

© 2011 • 422 pp., illus., index
(Hardcover edition includes online access; call for information and registration)
Hardcover • $318 • ISBN 978-1-936113-56-9

This volume is based on presentations by world-renowned investigators who gathered at the 76th Cold Spring Harbor Symposium on Quantitative Biology. It reviews the latest advances in our understanding of metabolism and disease, including research on fat, exercise and rhythms; insulin resistance and sensitivity; lifespan, aging and cancer; regulation and dysregulation of metabolism; signaling and gene regulation; environment and sensing; metabolic reprogramming; clocks and intermediary metabolism; metabolism and cancer; and autophagy, timing and small RNAs.

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Metabolism and Disease
(Cold Spring Harbor Symposia on Quantitative Biology LXXVI)

Edited By Terri Grodzicker, Cold Spring Harbor Laboratory; Bruce Stillman, Cold Spring Harbor Laboratory; David Stewart, Cold Spring Harbor Laboratory

© 2011 • 422 pp., illus., index
(Paperback edition does not include online access)
Paperback • $129 • ISBN 978-1-936113-57-6

This volume is based on presentations by world-renowned investigators who gathered at the 76th Cold Spring Harbor Symposium on Quantitative Biology. It reviews the latest advances in our understanding of metabolism and disease, including research on fat, exercise and rhythms; insulin resistance and sensitivity; lifespan, aging and cancer; regulation and dysregulation of metabolism; signaling and gene regulation; environment and sensing; metabolic reprogramming; clocks and intermediary metabolism; metabolism and cancer; and autophagy, timing and small RNAs.

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Methods in Yeast Genetics: A Cold Spring Harbor Laboratory Course Manual, 2005 Edition

By David C. Amberg, Upstate Medical University, Syracuse; Daniel J. Burke, University of Virginia Medical Center, Charlottesville; Jeffrey N. Strathern, National Cancer Institute

© 2005 • 230 pp., illus., index
Paperback • $96.00 • ISBN 978-087969728-0

“Methods in Yeast Genetics” is a course that has been offered annually at Cold Spring Harbor Laboratory for the last thirty years. This is an updated edition of the course manual, which provides a set of teaching experiments, along with protocols and recipes for the standard techniques and reagents used in the study of yeast biology. Since the last edition of the manual was published (2000), revolutionary advances in genomics and proteomics technologies have had a significant impact on the field. This updated edition reflects these advances, and also includes new techniques involving vital staining, visualization of Green Fluorescent Protein, new drug resistance markers, high-copy suppression, Tandem Affinity Protein tag protein purification, gene disruption by double-fusion polymerase chain reaction, and many other recent developments.