© 1996 • 1058 pp., illus., color plates, index
Cloth • $135 $27.00 • ISBN  978-087969459-3
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DNA replication is a central cog in the machinery of cell and viral proliferation. After significant advances in the past few years, its regulation is now understood in unprecedented depth.

This is the first book to provide a detailed and thoroughly up-to-date review of the complexity of DNA replication in eukaryotic cells. It is organized into three parts: Concepts, a distillation of underlying principles; Enzymes, a description of each protein class involved; and Systems, a review of events over a wide range of organisms. The book is therefore invaluable for teachers who want a current survey of a topic central to the biology syllabus; investigators of replication who will appreciate a remarkably concise, central source of knowledge in their specialty; and scientists studying other biological functions on which DNA replication has an impact.

  "The book contains 40 chapters written by 92 scientists, each a leading expert in his or her area. It is an outstanding achievement for which the authors and editor are to be congratulated.

The book is comprehensive and well balanced. It is logically divided into three sections, covering basic concepts, replication proteins and specific replication systems….

Overall, the book is very well written and edited. Each chapter contains generous background information that makes the ensuing discussion easily understandable — even for those individuals with little or no previous exposure to the field. Extensive cross-referencing and referencing makes it easy to find additional information both from within the book and from the original sources. Most chapters are also exceptionally well illustrated, with line drawings and photographs, some of which are in colour. In short, this book is an absolute must for anyone working in the DNA-replication field. Individuals working outside the field who desire a comprehensive survey of this subject for research or teaching purposes would also benefit from having a copy of the book within arm's reach."
      —Trends in Cell Biology

CONCEPTS

Mechanisms for Replicating DNA (G.S. Brush and T.J. Kelly); Origins of DNA Replication (M.L. DePamphilis); Roles of Transcription Factors in DNA Replication (P.C. van der Vliet); Roles of Nuclear Structure in DNA Replication (R. Laskey and M. Madine); Mechanisms for Priming DNA Synthesis (M. Salas, J.T. Miller, J. Leis, and M.L. DePamphilis); Mechanisms for Completing DNA Replication (D. Bastia and B.K. Mohanty); Fidelity of DNA Replication (J.D. Roberts and T.A. Kunkel); DNA Excision Repair Pathways (E.C. Friedberg and R.D. Wood); Chromatin Structure and DNA Replication: Implications for Transcriptional Activity (A.P. Wolffe); Roles of Phosphorylation in DNA Replication (K. Weisshart and E. Fanning); Control of S Phase (K. Nasmyth); Temporal Order of DNA Replication (I. Simon and H. Cedar); Changes in DNA Replication during Animal Development (J.L. Carminati and T.L. Orr-Weaver); Comparison of DNA Replication in Cells from Prokarya and Eukarya (B. Stillman)

Cellular DNA Polymerases (T.S.-F. Wang); Viral DNA Polymerases (D.M. Coen); DNA Replication Accessory Proteins (U. Hübscher, G. Maga, and V.N. Podust); DNA Helicases (J.A. Borowiec); DNA Ligases (R. Nash and T. Lindahl); DNA Topoisomerases (A. Hangaard Andersen, C. Bendixen, and O. Westergaard); DNA Telomerases (C.W. Greider, K. Collins, and C. Autexier)

SV40 and Polyomavirus DNA Replication (J.A. Hassell and B.T. Brinton); Papillomavirus DNA Replication (A. Stenlund); Adenovirus DNA Replication (R.T. Hay); Herpesvirus DNA Replication (M. Challberg); Epstein-Barr Virus DNA Replication (J.L. Yates); Poxvirus DNA Replication (P. Traktman); Parvovirus DNA Replication (S.F. Cotmore and P. Tattersall); Replication of the Hepatitis Virus Genome (C. Seeger and W.S. Mason); Geminivirus DNA Replication (D.M. Bisaro); Baculovirus DNA Replication (C.H. Ahrens, D.J. Leisy, and G.F. Rohrmann); DNA Replication in Yeast (C.S. Newlon); DNA Replication in Tetrahymena (G.M. Kapler, D.L. Dobbs, and E.H. Blackburn); DNA Replication in Physarum (G. Pierron and M. B'nard); Differential DNA Replication in Insects (S.A. Gerbi and F.D. Urnov); DNA Replication in Xenopus (J.J. Blow and J.P.J. Chong); DNA Replication in Mammals (N.H. Heintz); DNA Replication in Plants (J. Van't Hof); Mitochondrial DNA Replication (D.A. Clayton); Kinetoplast DNA Replication (A.F. Torri, L.J. Rocco Carpenter, and P.T. Englund)