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RNA: Life's Indispensable Molecule

By James Darnell, The Rockefeller University

© 2011 • 416 pp., illus., appendix, index
Hardcover • $40.00 • ISBN 978-1-936113-19-4

In RNA: Life’s Indispensable Molecule, Jim Darnell provides a comprehensive and captivating account of RNA research, illuminated by his own life-long and celebrated engagement in the field. Darnell describes how scientists unraveled fundamental questions about the biochemical and genetic importance of RNA—how mRNAs are generated and used to produce proteins, how noncoding and catalytic RNAs mediate key cellular processes, and how RNA molecules likely initiated life on Earth. With a scope extending from the early 20th century to the present day, and with the clarity expected from an accomplished textbook author, he conveys the intellectual context in which these questions first arose and explains how the key experiments were structured and answers obtained. The book is geared towards scientists from the graduate level on up, and will particularly appeal to active investigators in RNA biology, educators of molecular biology and biochemistry, and science historians.

About the Author

James E. Darnell, Jr., M.D. has been Vincent Astor Professor at The Rockefeller University since 1974. His career has included poliovirus research with Harry Eagle at the National Institutes of Health, research with François Jacob at the Pasteur Institute in Paris, and academic appointments at the Massachusetts Institute of Technology, Albert Einstein College of Medicine, and Columbia University. He has mentored over 120 doctoral students and postdoctoral scientists. From the very beginning of his first lab at MIT, Darnell, his students and postdocs have studied RNA, its synthesis, processing, and transcriptional regulation.

Darnell is a member of the National Academy of Sciences and has received numerous awards, including the 2003 National Medal of Science and the 2002 Albert Lasker Award for Special Achievement in Medical Science. He is the coauthor, with S.E. Luria, of General Virology (Wiley) and the founding author with Harvey Lodish and David Baltimore of Molecular Cell Biology

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An Introduction to Animal Behavior: An Integrative Approach

By Michael J. Ryan, The University of Texas at Austin; Walter Wilczynski, Neuroscience Institute, Georgia State University, Atlanta

© 2011 • 258 pp., illus. (88 color, 3 b/w), index
Paperback • $46.00 • ISBN 978-0-879698-58-4

The study of animal behavior is one of the most integrative endeavors in biology—it encompasses how the behavior is acquired, how it works, why it has come to work as it does, and how it influences the behaving animal and the animals around it. In Animal Behavior: An Integrative Approach, Michael J. Ryan and Walter Wilczynski address the interrelationship of these aspects of animal behavior, which Nikolaas Tinbergen codified in his “four questions” as causation, ontogeny, survival value, and evolution. In light of these questions, the authors first review some of the basic concepts of ultimate and proximate aspects of behavior. They make the argument that integrating different levels of analysis is critical for deriving a correct interpretation of behavior. In subsequent chapters, they review topics such as foraging, orientation and migration, sex differences, mate choice, social bonding, cooperation, conflict, and aggression. The authors integrate information from molecular genomics through neuroscience, endocrinology, development, and learning to evolutionary genetics, selection, constraints, and phylogenetics to provide a concise but comprehensive look at current topics in animal behavior. This book provides a well-thought-out and integrated introduction to the complexity of animal behavior that should appeal to advanced undergraduates, graduate students, and professional scientists in other fields in need of a succinct review of the field.

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An Introduction to Animal Behavior: An Integrative Approach

By Michael J. Ryan, The University of Texas at Austin; Walter Wilczynski, Neuroscience Institute, Georgia State University, Atlanta

© 2011 • 258 pp., illus. (88 color, 3 b/w), index
Hardcover • $81.00 • ISBN 978-1-936113-18-7

The study of animal behavior is one of the most integrative endeavors in biology—it encompasses how the behavior is acquired, how it works, why it has come to work as it does, and how it influences the behaving animal and the animals around it. In Animal Behavior: An Integrative Approach, Michael J. Ryan and Walter Wilczynski address the interrelationship of these aspects of animal behavior, which Nikolaas Tinbergen codified in his “four questions” as causation, ontogeny, survival value, and evolution. In light of these questions, the authors first review some of the basic concepts of ultimate and proximate aspects of behavior. They make the argument that integrating different levels of analysis is critical for deriving a correct interpretation of behavior. In subsequent chapters, they review topics such as foraging, orientation and migration, sex differences, mate choice, social bonding, cooperation, conflict, and aggression. The authors integrate information from molecular genomics through neuroscience, endocrinology, development, and learning to evolutionary genetics, selection, constraints, and phylogenetics to provide a concise but comprehensive look at current topics in animal behavior. This book provides a well-thought-out and integrated introduction to the complexity of animal behavior that should appeal to advanced undergraduates, graduate students, and professional scientists in other fields in need of a succinct review of the field.

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RNA Worlds: From Life’s Origins to Diversity in Gene Regulation

Edited By John F. Atkins, University of Utah, University College Cork, and Trinity College Dublin; Raymond F. Gesteland, University of Utah; Thomas R. Cech, Howard Hughes Medical Institute, University of Colorado

© 2011 • 366 pp., illus. (73 color, 23 b/w), index
Trim size: 8-1/2” x 10-7/8”
Hardcover • $162.00 • ISBN 978-0-879699-46-8

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The Origins of Life

Edited By David Deamer, University of California, Santa Cruz; Jack W. Szostak, Howard Hughes Medical Institute, Massachusetts General Hospital

© 2010 • 318 pp., illus. (47 color, 50 b/w), index
Trim size: 7” x 10”
Hardcover • $135 $33.75 • ISBN 978-1-936113-04-0

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Emerging Model Organisms: A Laboratory Manual, Volume 2

© 2010 • 624 pp., illus. (102 b/w), appendices, index
Trim size: 8-1/2” x 10-7/8”
Paperback • $91.00 • ISBN 978-0-879698-65-2

This second volume of the groundbreaking Emerging Model Organisms series expands the collection of species presented in the first volume. Leading experts provide 18 new chapters on emerging model systems, ranging from honeybee, ant, and beetle to Ciona and amphioxus; squid and salamander to yam, Paramecium, and wallaby. Like the first volume, each chapter presents a new organism and provides a detailed explanation of why it is useful for laboratory research, along with information on husbandry, genetics and genomics, pointers toward further resources, and a set of basic laboratory protocols for working with that organism. Emerging Model Organisms serves as a practical guidebook for finding just the right organism to address specific research needs.

Review of Volume 1:
“The first volume of Emerging Model Organisms illustrates the bewildering variety of natural histories and rapidly advancing techniques that have been developed to work with a wide spectrum of organisms. If Darwin were around now, he would have been the first to happily make use of this manual—and would be impatiently awaiting the forthcoming tome, describing the emergence of honeybees, squids, ascidians, rabbits, ants...and many more.” —Nature Cell Biology

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Emerging Model Organisms: A Laboratory Manual, Volume 2

© 2010 • 624 pp., illus. (102 b/w), appendices, index
Trim size: 8-1/2” x 10-7/8”
Hardcover • $162.00 • ISBN 978-0-879699-45-1

This second volume of the groundbreaking Emerging Model Organisms series expands the collection of species presented in the first volume. Leading experts provide 18 new chapters on emerging model systems, ranging from honeybee, ant, and beetle to Ciona and amphioxus; squid and salamander to yam, Paramecium, and wallaby. Like the first volume, each chapter presents a new organism and provides a detailed explanation of why it is useful for laboratory research, along with information on husbandry, genetics and genomics, pointers toward further resources, and a set of basic laboratory protocols for working with that organism. Emerging Model Organisms serves as a practical guidebook for finding just the right organism to address specific research needs.

Review of Volume 1:
“The first volume of Emerging Model Organisms illustrates the bewildering variety of natural histories and rapidly advancing techniques that have been developed to work with a wide spectrum of organisms. If Darwin were around now, he would have been the first to happily make use of this manual—and would be impatiently awaiting the forthcoming tome, describing the emergence of honeybees, squids, ascidians, rabbits, ants...and many more.” —Nature Cell Biology

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Evolution: The Molecular Landscape
(Cold Spring Harbor Symposia on Quantitative Biology LXXIV)

Edited By Bruce Stillman, Cold Spring Harbor Laboratory; David Stewart, Cold Spring Harbor Laboratory; Jan Witkowski, Cold Spring Harbor Laboratory

© 2009 • 485 pp., illus. (121 color; 86 b/w), indexes
Trim size: 7-3/4” x 10-3/4”
(Paperback edition does not include online access)
Paperback • $126 $31.50 • ISBN 978-087969871-3

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Evolution: The Molecular Landscape
(Cold Spring Harbor Symposia on Quantitative Biology LXXIV)

Edited By Bruce Stillman, Cold Spring Harbor Laboratory; David Stewart, Cold Spring Harbor Laboratory; Jan Witkowski, Cold Spring Harbor Laboratory

© 2009 • 485 pp., illus. (121 color; 86 b/w), indexes
Trim size: 7-3/4” x 10-3/4”
(Hardcover edition includes online access; call for information and registration)
Hardcover • $310 $77.50 • ISBN 978-087969870-6

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The Skeletal System
(Cold Spring Harbor Monograph Series 53)

Edited By Olivier Pourquié, Stowers Institute for Medical Research, Kansas City, Missouri

© 2009 • 365 pp., illus., index
Hardcover • $95 $47.50 • ISBN 978-087969825-6

The thirteen chapters presented in this book summarize our current understanding of the development, biology, and evolution of the vertebrate skeleton. Written by experts in the field, chapters cover everything from the differentiation of chondrocytes, limb and craniofacial patterning, and the origins and evolution of bone to the genetics of human skeletal disease. It is a useful reference for scientists and clinicians wishing to learn how the skeleton is built and works.