© 2001 • 550 pp., illus., index
Paperback • ISBN  0-87969-673-7

This title also available in: Hardcover

Stem cells are the focus of intense interest from a growing, multidisciplinary community of investigators with new tools for isolating and characterizing these elusive cell types. This volume, which features contributions from many of the world's leading laboratories, provides a uniquely broad and authoritative basis for understanding the biology of stem cells and the current excitement about their potential for clinical exploitation. It is an essential work of reference for investigators in embryology, hematology, and neurobiology, and their collaborators in the emerging field of regenerative medicine.

  "This book considers the rich evolutionary and developmental complexity of stem cells in chapters ranging from yeasts to people, embryos to adults, and all three layers of the developing embryo—mesoderm, ectoderm and endoderm. The editors have done an excellent job of recruiting distinguished authors, including veteran leaders in the field such as Brigid Hogan and Austin Smith, and younger stars such as Markus Grompe. As a result, the book is strong on credibility and perspective. Each chapter is consistently written in a way that is accessible to the non-specialist. This is therefore a very good book both for newcomers to stem-cell biology and for experts looking for new ideas by broadening their perspective….

If the future of basic stem-cell biology depends on our ability to integrate our understanding of different stem-cell systems, and if the future of applied stem-cell biology depends on our ability to explain the field to non-specialists, then this book is a welcome step into the future."
      —Nature

Preface

Section I: General Issues

Chapter 1:   Introduction: Stem Cell Biology

Daniel R. Marshak, David Gottlieb, and Richard L. Gardner

Chapter 2:   Differentiated Parental DNA Chain Causes Stem Cell Pattern of Cell-type Switching in Schizosaccharomyces pombe

Amar J.S. Klar

Chapter 3:   On Equivalence Groups and the Notch/LIN-12 Communication System

Domingos Henrique

Chapter 4:   Cell Cycle Control, Checkpoints, and Stem Cell Biology

Gennaro D’Urso and Sumana Datta

Chapter 5:   Senescence of Dividing Somatic Cells

Robin Holliday

Chapter 6:   Repopulating Patterns of Primitive Hematopoietic Stem Cells

David E. Harrison, Jichun Chen, and Clinton M. Astle

Section II: Early Development

Chapter 7:   The Drosophila Ovary: An In Vivo Stem Cell System

Ting Xie and Allan Spradling

Chapter 8:   Male Germ-line Stem Cells

Amy A. Kiger and Margaret T. Fuller

Chapter 9:   Primordial Germ Cells as Stem Cells

Brigid Hogan

Chapter 10:  Embryonic Stem Cells

Austin Smith

Chapter 11:  Embryonal Carcinoma Cells as Embryonic Stem Cells

Peter W. Andrews, Stefan A. Przyborski, and James A. Thomson

Chapter 12:  Trophoblast Stem Cells

Tilo Kunath, Dan Strumpf, Janet Rossant, and Satoshi Tanaka

Section III: Mesoderm

Chapter 13:  Hematopoietic Stem Cells: Molecular Diversification and Developmental Interrelationships

Stuart H. Orkin

Chapter 14:  Hematopoietic Stem Cells: Lymphopoiesis and the Problem of Commitment Versus Plasticity

Fritz Melchers and Antonius Rolink

Chapter 15:  The Hemangioblast

Gordon Keller

Chapter 16:  Mesenchymal Stem Cells of Human Adult Bone Marrow

Mark F. Pittenger and Daniel R. Marshak

Chapter 17:  Fate Mapping of Stem Cells

Alan W. Flake

Section IV: Ectoderm

Chapter 18:  Stem Cells and Neurogenesis

Mitradas M. Panicker and Mahendra Rao

Chapter 19:  Epidermal Stem Cells

Fiona M. Watt

Section V: Endoderm

Chapter 20:  Liver Stem Cells

Markus Grompe and Milton J. Finegold

Chapter 21:  Pancreatic Stem Cells

Marcie R. Kritzik and Nora Sarvetnick

Chapter 22:  Stem Cells in the Epithelium of the Small Intestine and Colon

Douglas J. Winton

Index