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DNA Replication

Edited By Stephen D. Bell, Indiana University, Bloomington; Marcel Méchali, Institute of Human Genetics, CNRS, Montpellier; Melvin L. DePamphilis, National Institutes of Health, Bethesda

© 2013 • 576 pp., illus. (88 4C, 33 B&W), appendices, index
Hardcover • $135 • ISBN 978-1-936113-48-4

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Next-Generation DNA Sequencing Informatics

Edited By Stuart M. Brown, New York University School of Medicine

© 2013 • 241 pp., illus. (48 4C & 15 B&W), index
Hardcover • $59 • ISBN 978-1-936113-87-3

Next-generation DNA sequencing (NGS) technology has revolutionized biomedical research, making complete genome sequencing an affordable and frequently used tool for a wide variety of research applications. Bioinformatics methods to support DNA sequencing have become a critical bottleneck for many researchers and organizations wishing to make use of NGS technology. This book provides a thorough introduction to the necessary informatics methods and tools for operating NGS instruments and analyzing NGS data. The book also provides extensive reference to best-practice bioinformatic methods for the most commonly used NGS technologies and applications. The book also includes reference to, and guidance on, the setup and use of essential software for NGS data analysis. This is the first book of its kind to address the informatics needs of scientists who wish to take advantage of the explosion of research opportunities offered by new DNA sequencing technologies.

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Genome Science: A Practical and Conceptual Introduction to Molecular Genetic Analysis in Eukaryotes

By David Micklos, Cold Spring Harbor Laboratory; Bruce Nash, Cold Spring Harbor Laboratory; Uwe Hilgert, University of Arizona

© 2013 • 704 pp., illus (3 4C, 606 B&W), index
Hardcover • $55 • ISBN 978-0-879698-59-1

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Protein Synthesis and Translational Control

Edited By John W.B. Hershey, University of California, Davis; Nahum Sonenberg, McGill University; Michael B. Mathews, New Jersey Medical School, University of Medicine and Dentistry of New Jersey

© 2012 • 352 pp., illustrations, index
Hardcover • $135 • ISBN 978-1-936113-46-0

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Molecular Cloning: A Laboratory Manual
(Fourth Edition)

By Michael R. Green, Howard Hughes Medical Institute, University of Massachusetts Medical School; Joseph Sambrook, Peter MacCallum Cancer Institute, Melbourne, Australia

© 2012 • 2,028 pp., illus., appendices, index
Paperback (three-volume set) • $365 $255.50 • ISBN 978-1-936113-42-2

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Molecular Cloning: A Laboratory Manual
(Fourth Edition)

By Michael R. Green, Howard Hughes Medical Institute, University of Massachusetts Medical School; Joseph Sambrook, Peter MacCallum Cancer Institute, Melbourne, Australia

© 2012 • 2,028 pp., illus., appendices, index
Cloth (three-volume set) • $475 $380.00 • ISBN 978-1-936113-41-5

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Mutation: The History of an Idea from Darwin to Genomics

By Elof Axel Carlson, Professor Emeritus, State University of New York at Stony Brook; Visiting Scholar, Institute for Advanced Study, Indiana University

© 2011 • 163 pp., illus. (11 b/w), index
Hardcover • $57.00 • ISBN 978-1-936113-30-9

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Guide to the Human Genome

By Stewart Scherer

© 2011 • 1,008 pp., illus. (212 b/w), appendix, index
Paperback • $79 • ISBN 978-0-879699-44-4

Presenting the genes of the human genome in their biological context, Guide to the Human Genome is an extensive online resource (also available in print) that provides easy access to information about human genes and their roles in specific processes. With numerous illustrations and tables, each of the nearly 300 sections of the Guide describes genes involved in a specific pathway, process, or structure—from the molecular and cellular levels to developmental and physiological processes. In the online version, these sections contain links to more information about proteins encoded by over 17,000 known or predicted human genes. For each protein, basic characteristics about its composition and length, its human relatives and relatedness to proteins in other species, and direct links to resources at NCBI are included. Additional links to NCBI resources are provided for human noncoding RNAs and repeated DNA elements and for proteins of interest from other species. The entire text of the Guide is searchable, and tools are available for identifying human protein sequences using those from other species. The Guide will be useful to researchers looking to connect sequence data with functional information, and can be used in parallel with traditional texts in undergraduate and graduate courses to provide a genomics dimension and experience of identifying genes underpinning processes of interest.

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Speaking of Genetics: A Collection of Interviews

Edited By Jane Gitschier, Institute for Human Genetics, University of California, San Francisco

© 2011 • 259 pp., illus., further reading, index
Paperback • $19.00 • ISBN 978-1-936113-03-3

These 22 interviews were conducted by University of California Professor Jane Gitschier for publication in the scientific journal PLoS Genetics over the past 5 years. Here these interviews are presented as a single, stand-alone collection for the first time.

The collection makes a compelling read by capturing exhilarating moments of discovery on a wide range of genetic questions as recounted by the scientists themselves. We also hear from scientists whose careers have taken on a broader role—a University president, a master teacher, an author, the founder of a company, and an explorer. Further perspective is provided by several non-scientists whose work helps frame our understanding and practice of genetics; these include a judge, a reporter, an administrator, and an historian of science. Together, the interviews in this collection bring to life the practice and societal implications of contemporary genetics.

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RNA Worlds: From Life’s Origins to Diversity in Gene Regulation

Edited By John F. Atkins, University of Utah, University College Cork, and Trinity College Dublin; Raymond F. Gesteland, University of Utah; Thomas R. Cech, Howard Hughes Medical Institute, University of Colorado

© 2011 • 366 pp., illus. (73 color, 23 b/w), index
Trim size: 8-1/2” x 10-7/8”
Hardcover • $162.00 • ISBN 978-0-879699-46-8