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The Synapse

Edited By Morgan Sheng, Genentech, Department of Neuroscience; Bernardo Sabatini, Harvard Medical School; Thomas C. Südhof, Stanford University School of Medicine

© 2012 • 397 pp., illus. (78 4C and 6 B&W images), index
Hardcover • $135 • ISBN 978-1-936113-02-6

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Telomeres, Second Edition
(Cold Spring Harbor Monograph Series 45)

Edited By Titia de Lange, The Rockefeller University; Vicki Lundblad, The Salk Institute for Biological Sciences; Elizabeth Blackburn, University of California, San Francisco

© 2006 • 576 pp., illus., index
Hardcover • $139 $27.80 • ISBN 978-087969734-1

An up–to–date survey of the current exciting state of telomere biology. Telomeres—specialized structures found at the ends of chromosomes— are essential for maintaining the integrity of chromosomes and their faithful duplication during cell division. Chapters in this volume cover telomere structure and function in a range of organisms, focusing on how they are maintained, their roles in cell division and gene expression, and how deficiencies in these structures contribute to cancers and other diseases and even aging.

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Telomeres, Second Edition
(Cold Spring Harbor Monograph Series 45)

Edited By Titia de Lange, The Rockefeller University; Vicki Lundblad, The Salk Institute for Biological Sciences; Elizabeth Blackburn, University of California, San Francisco

© 2006 • 576 pp., illus., index
Paperback • $49 $9.80 • ISBN 978-087969810-2

An up–to–date survey of the current exciting state of telomere biology. Telomeres—specialized structures found at the ends of chromosomes— are essential for maintaining the integrity of chromosomes and their faithful duplication during cell division. Chapters in this volume cover telomere structure and function in a range of organisms, focusing on how they are maintained, their roles in cell division and gene expression, and how deficiencies in these structures contribute to cancers and other diseases and even aging.

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The TGF-β Family
(Cold Spring Harbor Monograph Series 50)

Edited By Rik Derynck, University of California, San Francisco; Kohei Miyazono, University of Tokyo

© 2008 • 1,114 pp., illus., index
Hardcover • $135 $67.50 • ISBN 978-087969752-5

TGF-β is the prototype of a protein superfamily which, in humans, contains at least 35 members, including activins, inhibins, bone morphogenetic proteins, growth/differentiation factors, and Müllerian inhibiting substance. This monograph draws on the world’s leading laboratories to comprehensively cover all aspects of the biology of TGF-β and serve as a reference work for both specialists and researchers less familiar with the field.

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The Cardiovascular System
(Cold Spring Harbor Symposia on Quantitative Biology LXVII)

© 2002 • 566 pp., illus., color plates, appendices, index
Paperback • $115 $46.00 • ISBN 978-087969679-5

Normal cardiovascular function requires the concerted action of many cell types, each capable of adaptive gene expression in response to developmental, physiological, and pathological cues. The genetic basis of cardiovascular function, development, and disease is an area of intense investigation, in the hope of significant insights into the heart and vessels? basic workings and improvements in diagnosis and therapy. This latest volume in a prestigious book series presents a remarkable survey of current progress in these efforts, through the contributions of over fifty of the world's leading investigators. Sections are devoted to angiogenesis, cardiogenesis, homeostasis, development, vascular biology, and cardiovascular repair and therapy. The book is an essential source of ideas, discoveries, and references for clinical scientists and physicians interested in basic cardiac biology, hypertension, atherosclerosis, coronary artery disease, and heart failure.

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The Dog and Its Genome
(Cold Spring Harbor Monograph Series 44)

Edited By Elaine A. Ostrander, National Human Genome Research Institute, NIH; Urs Giger, School of Veterinary Medicine, University of Pennsylvania, Philadelphia; Kerstin Lindblad-Toh, Broad Institute of MIT and Harvard

© 2006 • 584 pp., illus., index
Hardcover • $139 • ISBN 978-087969742-6

Dogs of different breeds can range remarkably in size, shape, and behavior, and yet they all carry essentially the same genome, making them a particularly fascinating model for genome plasticity. The recent release of the complete sequence of the dog genome provides an exciting new context in which to consider such variation. Twenty–five chapters written by experts in the field include various aspects of morphological and behavioral variation in dogs, their origins and domestication, and their unique value as a model system for many common but complex human diseases such as diabetes and cancer.

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The Genome of Homo sapiens
(Cold Spring Harbor Symposia on Quantitative Biology LXVIII)

By Bruce Stillman, Cold Spring Harbor Laboratory; David Stewart, Cold Spring Harbor Laboratory

© 2003 • 544 pp., illus., appendices, index
(Hardcover edition includes online access; call for information and registration)
Hardcover • $310 $62.00 • ISBN 978-087969709-9

The Human Genome Project was completed in 2003, 50 years after the discovery of the structure of DNA and 17 years after an influential debate at the annual Cold Spring Harbor Laboratory Symposium about the Project’s feasibility. The 2003 Symposium was dedicated to examining what has been learned so far from the human genome sequence. This book contains over sixty contributions from the world’s leaders in this field and covers genome structure and evolution, methods of data analysis, lessons from species comparison, and the application of sequence data to the understanding of disease.

Purchasers of the hard cover edition of this book are entitled to access to the Symposia website at www.cshl-symposium.org. The site contains the full text of the written communications from the 2003 Symposium and the Symposia held in 1998 through 2002 (Volumes LXIII–LXVII). Subscribers to the site also gain access to archive photographs and selected papers from the 60–year history of the Annual Symposium.

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The Genome of Homo sapiens
(Cold Spring Harbor Symposia on Quantitative Biology LXVIII)

By Bruce Stillman, Cold Spring Harbor Laboratory; David Stewart, Cold Spring Harbor Laboratory

© 2003 • 544 pp., illus., appendices, index
(Paperback edition does not include online access)
Paperback • $126 $25.20 • ISBN 978-087969710-5

The Human Genome Project was completed in 2003, 50 years after the discovery of the structure of DNA and 17 years after an influential debate at the annual Cold Spring Harbor Laboratory Symposium about the Project’s feasibility. The 2003 Symposium was dedicated to examining what has been learned so far from the human genome sequence. This book contains over sixty contributions from the world’s leaders in this field and covers genome structure and evolution, methods of data analysis, lessons from species comparison, and the application of sequence data to the understanding of disease.

Purchasers of the hard cover edition of this book are entitled to access to the Symposia website at www.cshl-symposium.org. The site contains the full text of the written communications from the 2003 Symposium and the Symposia held in 1998 through 2002 (Volumes LXIII–LXVII). Subscribers to the site also gain access to archive photographs and selected papers from the 60–year history of the Annual Symposium.

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The Molecular Gaze: Art in the Genetic Age

By Suzanne Anker, School of Visual Arts, New York; Dorothy Nelkin, New York University

© 2004 • 216 pp., illus., index
Hardcover • $47 $23.50 • ISBN 978-087969697-9

The gene has become a cultural icon and an increasingly rich source of imagery and ideas for visual artists. Drawing on a wide range of contemporary painting and sculpture, The Molecular Gaze: Art in the Genetic Age explores the moral and bioethical questions these works address. What does it mean to be human? What is “identity” in a society of genetically manipulated individuals? Questions like these are growing louder as genetic technology advances and the public examines the ethical consequences more widely. Suzanne Anker and Dorothy Nelkin, an artist and a social scientist, have written a thought–provoking and visually fascinating book for scientists, artists, students, and general readers intrigued by the anxiety and exhilaration of the genetic age.

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The Unfit: A History of a Bad Idea

By Elof Axel Carlson, Professor Emeritus, State University of New York at Stony Brook

© 2001 • 451 pp., illus., bibliography, indexes
Book of the Year for 2001 in Amazon's Professional Science Category!
Hardcover • $26 $6.50 • ISBN 978-087969587-3

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Times of Triumph, Times of Doubt: Science and the Battle for Public Trust

By Elof Axel Carlson, Professor Emeritus, State University of New York at Stony Brook

© 2006 • 227 pp., index
Hardcover • $39 $15.60 • ISBN 978-087969805-8

The intent and uses of science are a continuing preoccupation, especially in public debates on issues such as new pharmaceuticals, cloning, stem cells, genetically modified foods, and assisted reproduction. Times of Triumph, Times of Doubt, written by the eminent geneticist and historian Elof Carlson, explores the moral foundations of science and their role in these hot–button issues. Carlson chooses a variety of case histories and describes their scientific background and the part played by scientists in the application of their work, including their motivations and reactions to bad outcomes, both real and alleged. He examines why ethical lapses have occurred in these areas, why bad things happen when, for the most part, those who worked on the science had only good intentions in mind, and how such lapses can be prevented from occurring in the future. This exploration of ethics and science is important reading for those interested in issues of science and society, including journalists, theologians, legislators, lawyers, and scientists themselves.

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Transcriptional Regulation in Eukaryotes: Concepts, Strategies, and Techniques, Second Edition

By Michael F. Carey, University of California, Los Angeles; Craig L. Peterson, University of Massachusetts Medical School, Worcester; Stephen T. Smale, University of California, Los Angeles

© 2009 • 620 pp., appendix, index
Hardcover • $246.00 • ISBN 978-087969777-8

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Transcriptional Regulation in Eukaryotes: Concepts, Strategies, and Techniques, Second Edition

By Michael F. Carey, University of California, Los Angeles; Craig L. Peterson, University of Massachusetts Medical School, Worcester; Stephen T. Smale, University of California, Los Angeles

© 2009 • 620 pp., appendix, index
Paperback • $169.00 • ISBN 978-087969762-4

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Translational Control in Biology and Medicine
(Cold Spring Harbor Monograph Series 48)

Edited By Michael B. Mathews, UMDNJ-New Jersey Medical School, Newark, New Jersey; Nahum Sonenberg, McGill University, Montreal, Canada; John W.B. Hershey, University of California, Davis

© 2007 • 934 pp., illus., index
Hardcover • $139 $34.75 • ISBN 978-087969767-9

The new edition of this successful monograph has been both updated and broadened. Since the previous (second) edition was published in 2000, the structures of the bacterial and eukaryotic ribosomes have been published, advancing our basic understanding of translation and mechanisms involving protein and RNA regulators. In addition, as the title indicates, this edition has a new focus on the role of translational control in human development and disease. This book, with 30 chapters written by experts in the field, is essential reading for anyone interested in the process of translation, its regulation, and how its failure can be the cause of disease.

View two different sets of sample pages from the book here — and here —

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Type 1 Diabetes

Edited By Jeffrey A. Bluestone, University of California at San Francisco; Mark A. Atkinson, University of Florida, College of Medicine; Peter R. Arvan, University of Michigan Health System

© 2012 • 305 pp., illus., index
Hardcover • $135 • ISBN 978-1-936113-21-7

Type 1 diabetes, also known as juvenile-onset or insulin-dependent diabetes mellitus (IDDM), is caused by destruction of insulin-producing β cells in the pancreas by the body’s immune system. It affects hundreds of thousands of individuals worldwide, requiring regular insulin injections to control blood glucose levels and avoid severe consequences of glucose dysregulation. Written by experts in the field, this book provides a detailed examination of our understanding of the disease process and its causes, as well as genetic risk factors, animal models of diabetes, and new treatment strategies that are being developed.

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Untangling the Double Helix
DNA Entanglement and the Action of the DNA Topoisomerases

By James C. Wang, Harvard University

© 2009 • 233 pp., illus., appendices, index
Hardcover • $81.00 • ISBN 978-087969863-8

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Untangling the Double Helix
DNA Entanglement and the Action of the DNA Topoisomerases

By James C. Wang, Harvard University

© 2009 • 233 pp., illus., appendices, index
Paperback • $46.00 • ISBN 978-087969879-9

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We Can Sleep Later: Alfred D. Hershey and the Origins of Molecular Biology

Edited By Franklin W. Stahl, University of Oregon, Eugene

© 2000 • 357 pp., illus., indexes
Hardcover • $41 $20.50 • ISBN 978-087969567-5

An absorbing portrait of the pioneering molecular biologist best known for demonstrating that DNA is the genetic component of phages, through essays and reminiscences from twenty–three distinguished scientists whose work and careers were influenced by the man and his science.

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What a Time I Am Having: Selected Letters of Max Perutz

Edited By Vivien Perutz

© 2009 • 506 pp., illus., index
Hardcover • $40.00 • ISBN 978-087969864-5

Selected by his daughter, Vivien, from Max Perutz’s voluminous correspondence, the letters reproduced here portray their author with a spontaneity and directness no autobiography could have matched. They chronicle Perutz’s adventurous life through his own vivid, erudite and humorous pen, documenting the hopes, roadblocks and moments of elation of his sixty-year quest to understand the molecular biology of hemoglobin. The first great step in this quest — unraveling the molecular structure of hemoglobin — earned Perutz the 1962 Nobel Prize in Chemistry. Narrated against a backdrop of family and friends, politics and war, literature, travels, and Max’s beloved mountains, these letters provide rare insight into the thoughts of a remarkable and very human scientist, and delightful sketches of some of the people he encountered. Starting with lively letters to a girlfriend written in his youth in Vienna and the impressions of a young scientist in Cambridge, the letters progress to the desperate pleas of an “enemy alien” interned in Canada during World War II. The diary of Perutz’s subsequent super-secret war work for the British to build a floating ice airstrip in the North Atlantic, ardent campaigning letters to scientists and politicians, and self-deprecating stories of his own mishaps written to amuse his children and grandchildren are some of the many highlights of these fascinating letters, unique in the annals of recent scientific history. This book is a companion to Georgina Ferry’s Max Perutz and the Secret of Life. Together these volumes provide a portrait of an extraordinary character in the development of molecular biology.

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Wnt Signaling

Edited By Roel Nusse, Stanford University Medical Center; Xi He, Children’s Hospital Boston; Renée van Amerongen, Stanford University Medical Center

© 2013 • 454 pp., illus. (75 4C and 6 B&W), index
Hardcover • $135 • ISBN 978-1-936113-23-1

Wnt proteins are signaling molecules that play critical roles during embryonic development and in the regeneration of adult tissues. They bind to Frizzled and LRP family receptors on the cell surface, triggering a series of events that cause β-catenin to enter the nucleus and activate transcription factors that control cell fate and cell proliferation. Mutations in components of the Wnt pathway lead to developmental defects and are common in cancer.

Written and edited by experts in the field, this collection from Cold Spring Harbor Perspectives in Biology covers all aspects of canonical Wnt signaling, as well as β-catenin-independent Wnt signaling and cross-talk with other pathways. The contributors examine the numerous Wnt ligands; their production, secretion, and interactions with components of the extracellular environment; and details of the downstream signaling pathways that mediate the effects of Wnt proteins on cells. The roles of Wnt signaling in stem cell self-renewal, cell polarity, body-axis specification, wound healing, and other aspects of normal development and physiology are also covered.

This volume includes discussion of Wnt signaling in cancer, skeletal defects, neurological disorders, and other human disease states. Thus, it is an indispensable reference for cell and developmental biologists as well as those, especially in the fields of stem cell biology and regenerative medicine, who are interested in targeting the Wnt pathway for therapeutic purposes.

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Won for All: How the Drosophila Genome Was Sequenced

By Michael Ashburner

© 2006 • 107 pp., illus.
Hardcover • $19.95 $9.97 • ISBN 978-087969802-7

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The Writing Life of James D. Watson

By Errol C. Friedberg, University of Texas Southwestern Medical Center

© 2005 • 193 pp., illus., index
Hardcover • $26 $5.20 • ISBN 978-087969700-6

James Watson's fame as a scientist and research leader overshadows his considerable achievements as an innovator in the form and style of scientific communication. This book surveys Watson's books and essays from the perennially best–selling The Double Helix through his classic textbooks of the 1960s and 70s, polemics on ethical questions about genetic technology, to more recent works of autobiography.

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Yeast Intermediary Metabolism

By Dan G. Fraenkel, Harvard Medical School

© 2011 • 434 pp., illus. (138 b/w), appendix, index
Hardcover • $128 • ISBN 978-0-879697-97-6

The intermediary metabolism of small molecules is the meat and potatoes of cell function. The pathways and modes of obtaining energy, degradation and utilization of exogenous organic nutrients, and formation of the building blocks of the main macromolecules were a major focus of research in biology from the turn of the 20th century into the 1970s. Other matters have come to prominence, but the field is active, with interesting problems that are central to biology and medicine. Molecular biology developed through the use of one bacterium, Eschericha coli, with the saying “What’s true for E. coli is true for elephants.” In recent years, an analogous workhorse has been the eukaryotic microbe baker’s yeast, Saccharomyces cerevisiae, used in many studies of cell biology common to multicellular organisms. This book explains metabolism as based on Saccharomyces. The topics include central metabolic pathways; catabolism; fermentation; respiration; biosynthesis of small molecules including cofactors; the metabolism of lipids, polysaccharides, and storage molecules; inorganic ions; transport and compartments; the global analysis of metabolism; and issues of metabolic toxicity. It can be used in courses and as a reference book for research investigators.