More INFO on
this Product

From a to α: Yeast as a Model for Cellular Differentiation

By Hiten D. Madhani, University of California, San Francisco

© 2007 • 115 pp., illus., index
Hardcover • $65 $32.50 • ISBN 978-087969737-2

More INFO on
this Product

The Dog and Its Genome
(Cold Spring Harbor Monograph Series 44)

Edited By Elaine A. Ostrander, National Human Genome Research Institute, NIH; Urs Giger, School of Veterinary Medicine, University of Pennsylvania, Philadelphia; Kerstin Lindblad-Toh, Broad Institute of MIT and Harvard

© 2006 • 584 pp., illus., index
Hardcover • $139 • ISBN 978-087969742-6

Dogs of different breeds can range remarkably in size, shape, and behavior, and yet they all carry essentially the same genome, making them a particularly fascinating model for genome plasticity. The recent release of the complete sequence of the dog genome provides an exciting new context in which to consider such variation. Twenty–five chapters written by experts in the field include various aspects of morphological and behavioral variation in dogs, their origins and domestication, and their unique value as a model system for many common but complex human diseases such as diabetes and cancer.

More INFO on
this Product

Cell Biology of Addiction

Edited By Bertha K. Madras, Harvard Medical School; Christine M. Colvis, National Institute on Drug Abuse/NIH; Jonathan D. Pollock, National Institute on Drug Abuse/NIH; Joni L. Rutter, National Institute on Drug Abuse/NIH; David Shurtleff, National Institute on Drug Abuse/NIH; Mark von Zastrow, University of California, San Francisco

© 2006 • 465 pp., illus., appendices, index
Hardcover • $129 $32.25 • ISBN 978-087969753-2

This monograph, written by experts in the field, is devoted to the molecular analysis of addiction pathways in the brain. It provides an intensive overview of the fundamentals, state–of–the–art advances, and major gaps in the cell and molecular biology of drug addiction within the broader context of neuroscience. Addiction research is a branch of neuroscience and psychology. The emphasis in this book is on hard science and the market for it will be found among research investigators and grad students within the field of neuroscience. The research presented is not only applicable to the study of drug abuse and addiction, but has clear implications for clarifying mechanisms of learning and memory, neuroadaptation, perception, volitional behavior, motivation, reward, and other disciplines of neuroscience.

More INFO on
this Product

Mouse Phenotypes: A Handbook of Mutation Analysis

By Virginia E. Papaioannou, Columbia University College of Physicians and Surgeons; Richard R. Behringer, University of Texas MD Anderson Cancer Center

© 2005 • 235 pp., illus., appendices, index
Concealed wire binding • $91.00 • ISBN 978-087969640-5

The generation of mutant mice raises many questions about the best means of phenotypic analysis, breeding, and maintenance. The answers are now available from two experts with a wealth of detailed knowledge never previously assembled in one volume. Informal and highly practical, this handbook provides step–by–step methods for troubleshooting experiments, from the basics of gene targeting through the analysis of postnatal effects.

More INFO on
this Product

Gastrulation: From Cells to Embryo

Edited By Claudio D. Stern, University College London

© 2004 • 731 pp., illus., appendices, index
Printed hardcover • $158 $79.00 • ISBN 978-087969707-5

During gastrulation, tissue layers are formed and the overall body plan is established. This book is the definitive guide to this vitally important period in embryonic development, providing authoritative and up to date information that includes the first comprehensive interspecies comparison, cell movements and patterning events, the roles of individual genes and gene families, and the evolution of gastrulation.

More INFO on
this Product

Fly Pushing: The Theory and Practice of Drosophila Genetics, Second Edition

By Ralph J. Greenspan, The Neurosciences Institute, San Diego

© 2004 • 191 pp., illus., appendices, index
Concealed wire binding • $61.00 • ISBN 978-087969711-2

More INFO on
this Product

Cell Growth: Control of Cell Size
(Cold Spring Harbor Monograph Series 42)

Edited By Michael N. Hall, Biozentrum, University of Basel; Martin Raff, University College London; George Thomas, Friedrich Miescher Institute

© 2004 • 652 pp., illus., appendices, index
Hardcover • $139 $27.80 • ISBN 978-087969672-6

Recent breakthroughs in the field of cell growth, particularly in the control of cell size, are reviewed by experts in the three major divisions of the field: growth of individual cells, growth of organs, and regulation of cell growth in the contexts of development and cell division. This book is an introductory overview of the field and should be adaptable as a textbook.

More INFO on
this Product

A Genetic Switch, Third Edition, Phage Lambda Revisited

By Mark Ptashne, Sloan-Kettering Memorial Cancer Center, New York

© 2004 • 154 pp., illus., appendices, index
Paperback • $40.00 • ISBN 978-087969716-7

The first edition of Mark Ptashne's 1986 book describing the principles of gene regulation in phage lambda became a classic in both content and form, setting a standard of clarity and precise prose that has rarely been bettered. This edition is a reprint of the original text, together with a new chapter updating the story to 2004. Among the striking new developments are recent findings on long–range interactions between proteins bound to widely separated sites on the phage genome, and a detailed description of how gene activation works.

More INFO on
this Product

Prion Biology and Diseases, Second Edition
(Cold Spring Harbor Monograph Series 41)

Edited By Stanley B. Prusiner, University of California, San Francisco

© 2004 • 1,050 pp., illus., color plates, glossary, appendix, index
Hardcover • $147 $29.40 • ISBN 978-087969693-1

This volume is a new edition of the most authoritative book on Prion Biology, first published in 1999 and edited by the Nobel Prize–winning founder of the field. This expanded edition has been completely updated, and includes chapters on therapeutics, and diagnostic methods and approaches.

More INFO on
this Product

RNAi: A Guide to Gene Silencing

Edited By Gregory J. Hannon, Cold Spring Harbor Laboratory

© 2003 • 436 pp., illus., index
Paperback • $75 $15.00 • ISBN 978-087969704-4

The ability of double stranded RNA to inhibit the expression of genes with an appropriate sequence can be harnessed to silence target genes in vitro in a new and powerful way. This volume combines reliable RNAi protocols for a variety of species with discussion of strategies for the effective design of experiments using this important new technique that is changing the way experimental science is done.