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Genomes
(Cold Spring Harbor Monograph Series 46)

Edited By Hillary E. Sussman, Cold Spring Harbor Laboratory; Maria A. Smit, Cold Spring Harbor Laboratory

© 2006 • 475 pp., illus., index
Hardcover • $139 $34.75 • ISBN 978-087969806-5

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Won for All: How the Drosophila Genome Was Sequenced

By Michael Ashburner

© 2006 • 107 pp., illus.
Hardcover • $19.95 $9.97 • ISBN 978-087969802-7

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The Dog and Its Genome
(Cold Spring Harbor Monograph Series 44)

Edited By Elaine A. Ostrander, National Human Genome Research Institute, NIH; Urs Giger, School of Veterinary Medicine, University of Pennsylvania, Philadelphia; Kerstin Lindblad-Toh, Broad Institute of MIT and Harvard

© 2006 • 584 pp., illus., index
Hardcover • $139 • ISBN 978-087969742-6

Dogs of different breeds can range remarkably in size, shape, and behavior, and yet they all carry essentially the same genome, making them a particularly fascinating model for genome plasticity. The recent release of the complete sequence of the dog genome provides an exciting new context in which to consider such variation. Twenty–five chapters written by experts in the field include various aspects of morphological and behavioral variation in dogs, their origins and domestication, and their unique value as a model system for many common but complex human diseases such as diabetes and cancer.

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Cell Biology of Addiction

Edited By Bertha K. Madras, Harvard Medical School; Christine M. Colvis, National Institute on Drug Abuse/NIH; Jonathan D. Pollock, National Institute on Drug Abuse/NIH; Joni L. Rutter, National Institute on Drug Abuse/NIH; David Shurtleff, National Institute on Drug Abuse/NIH; Mark von Zastrow, University of California, San Francisco

© 2006 • 465 pp., illus., appendices, index
Hardcover • $129 $32.25 • ISBN 978-087969753-2

This monograph, written by experts in the field, is devoted to the molecular analysis of addiction pathways in the brain. It provides an intensive overview of the fundamentals, state–of–the–art advances, and major gaps in the cell and molecular biology of drug addiction within the broader context of neuroscience. Addiction research is a branch of neuroscience and psychology. The emphasis in this book is on hard science and the market for it will be found among research investigators and grad students within the field of neuroscience. The research presented is not only applicable to the study of drug abuse and addiction, but has clear implications for clarifying mechanisms of learning and memory, neuroadaptation, perception, volitional behavior, motivation, reward, and other disciplines of neuroscience.

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Landmark Papers in Yeast Biology

Edited By Patrick Linder, University of Geneva; David Shore, University of Geneva; Michael N. Hall, Biozentrum, University of Basel

© 2006 • 306 pp., index, CD
Printed hardcover • $99 $24.75 • ISBN 978-087969643-6

Yeast has been a preeminent experimental organism of genetic research for more than 50 years. Progress in the field has provided the conceptual framework that has driven experiments in many areas of biology. Landmark Papers in Yeast Biology consists of essays by prominent scientists on the context and significance of 71 carefully selected research papers, which are reprinted on the accompanying CD.  The papers include early, hard–to–find classics as well as more recent advances in areas such as signal transduction, membrane trafficking, protein turnover, and genomics. This collection has unique value for all scholars of yeast and could provide the foundation for a literature–based course on molecular cell biology.  As Jasper Rine notes in his eloquent introduction, the editors and contributors share the belief that “deep study of the agreed–on classics is the best training for learning how to recognize those contemporary papers worthy of our personal time....”

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The Inside Story: DNA to RNA to Protein

Edited By Jan Witkowski, Cold Spring Harbor Laboratory

© 2005 • 382 pp., illus., index
Paperback • $29 $14.50 • ISBN 978-087969750-1

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Methods in Yeast Genetics: A Cold Spring Harbor Laboratory Course Manual, 2005 Edition

By David C. Amberg, Upstate Medical University, Syracuse; Daniel J. Burke, University of Virginia Medical Center, Charlottesville; Jeffrey N. Strathern, National Cancer Institute

© 2005 • 230 pp., illus., index
Paperback • $96.00 • ISBN 978-087969728-0

“Methods in Yeast Genetics” is a course that has been offered annually at Cold Spring Harbor Laboratory for the last thirty years. This is an updated edition of the course manual, which provides a set of teaching experiments, along with protocols and recipes for the standard techniques and reagents used in the study of yeast biology. Since the last edition of the manual was published (2000), revolutionary advances in genomics and proteomics technologies have had a significant impact on the field. This updated edition reflects these advances, and also includes new techniques involving vital staining, visualization of Green Fluorescent Protein, new drug resistance markers, high-copy suppression, Tandem Affinity Protein tag protein purification, gene disruption by double-fusion polymerase chain reaction, and many other recent developments.

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The Writing Life of James D. Watson

By Errol C. Friedberg, University of Texas Southwestern Medical Center

© 2005 • 193 pp., illus., index
Hardcover • $26 $5.20 • ISBN 978-087969700-6

James Watson's fame as a scientist and research leader overshadows his considerable achievements as an innovator in the form and style of scientific communication. This book surveys Watson's books and essays from the perennially best–selling The Double Helix through his classic textbooks of the 1960s and 70s, polemics on ethical questions about genetic technology, to more recent works of autobiography.

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Epigenetics
(Cold Spring Harbor Symposia on Quantitative Biology LXIX)

Edited By Bruce Stillman, Cold Spring Harbor Laboratory; David Stewart, Cold Spring Harbor Laboratory

© 2004 • 532 pp., illus., index
(Paperback edition does not include online access)
Paperback • $126 $63.00 • ISBN 978-087969731-0

The importance of epigenetic regulation of gene expression, particularly in higher organisms, is now clear and the 2004 Cold Spring Harbor Annual Symposium provided many new examples as well as insights into the underlying mechanisms. The resulting volume—with over 60 papers from experts across the field—covers various aspects of nuclear organization and dynamics; genomic imprinting, chromosomal inactivation, and other examples of gene silencing; the histone and DNA modifications associated with these conditions; and the roles of RNA and protein regulators in establishing and maintaining these states.

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Epigenetics
(Cold Spring Harbor Symposia on Quantitative Biology LXIX)

Edited By Bruce Stillman, Cold Spring Harbor Laboratory; David Stewart, Cold Spring Harbor Laboratory

© 2004 • 532 pp., illus., index
(Hardcover edition includes online access; call for information and registration)
Hardcover • $310 $77.50 • ISBN 978-087969729-7

The importance of epigenetic regulation of gene expression, particularly in higher organisms, is now clear and the 2004 Cold Spring Harbor Annual Symposium provided many new examples as well as insights into the underlying mechanisms. The resulting volume—with over 60 papers from experts across the field—covers various aspects of nuclear organization and dynamics; genomic imprinting, chromosomal inactivation, and other examples of gene silencing; the histone and DNA modifications associated with these conditions; and the roles of RNA and protein regulators in establishing and maintaining these states.