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Means to an End: Apoptosis and Other Cell Death Mechanisms

By Douglas R. Green, St. Jude Children’s Research Hospital

© 2011 • 220 pp., additional reading, index
Hardcover • $81.00 • ISBN 978-0-879698-87-4

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Speaking of Genetics: A Collection of Interviews

Edited By Jane Gitschier, Institute for Human Genetics, University of California, San Francisco

© 2011 • 259 pp., illus., further reading, index
Paperback • $19.00 • ISBN 978-1-936113-03-3

These 22 interviews were conducted by University of California Professor Jane Gitschier for publication in the scientific journal PLoS Genetics over the past 5 years. Here these interviews are presented as a single, stand-alone collection for the first time.

The collection makes a compelling read by capturing exhilarating moments of discovery on a wide range of genetic questions as recounted by the scientists themselves. We also hear from scientists whose careers have taken on a broader role—a University president, a master teacher, an author, the founder of a company, and an explorer. Further perspective is provided by several non-scientists whose work helps frame our understanding and practice of genetics; these include a judge, a reporter, an administrator, and an historian of science. Together, the interviews in this collection bring to life the practice and societal implications of contemporary genetics.

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Imaging in Developmental Biology: A Laboratory Manual

Edited By James Sharpe, EMBL-CRG Systems Biology Unit, Barcelona, Spain; Rachel Wong, University of Washington; Series Editor, Rafael Yuste, Howard Hughes Medical Institute, Columbia University

© 2011 • 883 pp., illus., index
Paperback • $169.00 $118.30 • ISBN 978-0-879699-40-6

New imaging technologies have revolutionized the study of developmental biology. Where researchers once struggled to connect events at static timepoints, imaging tools now offer the ability to visualize the dynamic form and function of molecules, cells, tissues, and whole embryos throughout the entire developmental process. Imaging in Developmental Biology: A Laboratory Manual, a new volume in Cold Spring Harbor Laboratory Press’ Imaging series, presents a comprehensive set of essential visualization methods. The manual features primers on live imaging of a variety of standard model organisms including C. elegans, Drosophila, zebrafish, Xenopus, avian species, and mouse. Further techniques are organized by the level of visualization they provide, from cells to tissues and organs to whole embryos. Methods range from the basics of labeling cells to cutting-edge protocols for high-speed imaging, optical projection tomography, and digital scanned laser light-sheet fluorescence. Imaging has become a required methodology for developmental biologists, and Imaging in Developmental Biology: A Laboratory Manual provides the detailed explanations and instructions for mastering these necessary techniques.

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Imaging in Developmental Biology: A Laboratory Manual

Edited By James Sharpe, EMBL-CRG Systems Biology Unit, Barcelona, Spain; Rachel Wong, University of Washington; Series Editor, Rafael Yuste, Howard Hughes Medical Institute, Columbia University

© 2011 • 883 pp., illus., index
Hardcover • $246.00 $172.20 • ISBN 978-0-879699-39-0

New imaging technologies have revolutionized the study of developmental biology. Where researchers once struggled to connect events at static timepoints, imaging tools now offer the ability to visualize the dynamic form and function of molecules, cells, tissues, and whole embryos throughout the entire developmental process. Imaging in Developmental Biology: A Laboratory Manual, a new volume in Cold Spring Harbor Laboratory Press’ Imaging series, presents a comprehensive set of essential visualization methods. The manual features primers on live imaging of a variety of standard model organisms including C. elegans, Drosophila, zebrafish, Xenopus, avian species, and mouse. Further techniques are organized by the level of visualization they provide, from cells to tissues and organs to whole embryos. Methods range from the basics of labeling cells to cutting-edge protocols for high-speed imaging, optical projection tomography, and digital scanned laser light-sheet fluorescence. Imaging has become a required methodology for developmental biologists, and Imaging in Developmental Biology: A Laboratory Manual provides the detailed explanations and instructions for mastering these necessary techniques.

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Immunoreceptor Signaling

Edited By Lawrence E. Samelson, National Institutes of Health; Andrey Shaw, Washington University School of Medicine

© 2011 • 282 pp., illus. (49 color, 7 b/w), index
Trim size: 7” x 10”
Hardcover • $135 $33.75 • ISBN 978-0-879698-96-6

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RNA Worlds: From Life’s Origins to Diversity in Gene Regulation

Edited By John F. Atkins, University of Utah, University College Cork, and Trinity College Dublin; Raymond F. Gesteland, University of Utah; Thomas R. Cech, Howard Hughes Medical Institute, University of Colorado

© 2011 • 366 pp., illus. (73 color, 23 b/w), index
Trim size: 8-1/2” x 10-7/8”
Hardcover • $162.00 • ISBN 978-0-879699-46-8

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Imaging: A Laboratory Manual

Edited By Rafael Yuste, Howard Hughes Medical Institute, Columbia University

© 2011 • 952 pp., illus. (182 color, 97 b/w), appendices, index
Trim size: 8-1/2” x 10-7/8”
Paperback • $169.00 $118.30 • ISBN 978-0-879699-36-9

In recent years, imaging has rapidly become a tremendously valuable approach in nearly every field of biological research. Finding the right method and optimizing it for data collection can be a daunting process, even for an established imaging laboratory. Imaging: A Laboratory Manual is the cornerstone of a new laboratory manual series, designed as an essential guide for investigators who need these visualization techniques. This first volume is meant as a general reference for all fields, and describes the theory and practice of a wide array of imaging methods. From the basic chapters on optics, equipment and labeling to detailed explanations of advanced, cutting-edge methods like PALM, STORM, light sheet and high speed microscopy, Imaging: A Laboratory Manual is a vital resource for the modern biology laboratory.

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Imaging: A Laboratory Manual

Edited By Rafael Yuste, Howard Hughes Medical Institute, Columbia University

© 2011 • 952 pp., illus. (182 color, 97 b/w), appendices, index
Trim size: 8-1/2” x 10-7/8”
Hardcover • $246.00 $172.20 • ISBN 978-0-879699-35-2

In recent years, imaging has rapidly become a tremendously valuable approach in nearly every field of biological research. Finding the right method and optimizing it for data collection can be a daunting process, even for an established imaging laboratory. Imaging: A Laboratory Manual is the cornerstone of a new laboratory manual series, designed as an essential guide for investigators who need these visualization techniques. This first volume is meant as a general reference for all fields, and describes the theory and practice of a wide array of imaging methods. From the basic chapters on optics, equipment and labeling to detailed explanations of advanced, cutting-edge methods like PALM, STORM, light sheet and high speed microscopy, Imaging: A Laboratory Manual is a vital resource for the modern biology laboratory.

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The Honest Look

By Jennifer L. Rohn

© 2011 • 300 pp.
Paperback • $15.00 • ISBN 978-1-936113-11-8

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The Nucleus

Edited By Tom Misteli, National Cancer Institute/National Institutes of Health; David L. Spector, Cold Spring Harbor Laboratory

© 2011 • 517 pp., illus. (82 color, 17 b/w), index
Trim size: 7” x 10”
Hardcover • $135 $33.75 • ISBN 978-0-879698-94-2