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Addiction

Edited By R. Christopher Pierce, University of Pennsylvania; Paul J. Kenny, The Scripps Research Institute

© 2013 • 368 pp., illus (30 4C and 25 B&W), index
Hardcover • $135 • ISBN 978-1-936113-47-7

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Wnt Signaling

Edited By Roel Nusse, Stanford University Medical Center; Xi He, Children’s Hospital Boston; Renée van Amerongen, Stanford University Medical Center

© 2013 • 454 pp., illus. (75 4C and 6 B&W), index
Hardcover • $135 • ISBN 978-1-936113-23-1

Wnt proteins are signaling molecules that play critical roles during embryonic development and in the regeneration of adult tissues. They bind to Frizzled and LRP family receptors on the cell surface, triggering a series of events that cause β-catenin to enter the nucleus and activate transcription factors that control cell fate and cell proliferation. Mutations in components of the Wnt pathway lead to developmental defects and are common in cancer.

Written and edited by experts in the field, this collection from Cold Spring Harbor Perspectives in Biology covers all aspects of canonical Wnt signaling, as well as β-catenin-independent Wnt signaling and cross-talk with other pathways. The contributors examine the numerous Wnt ligands; their production, secretion, and interactions with components of the extracellular environment; and details of the downstream signaling pathways that mediate the effects of Wnt proteins on cells. The roles of Wnt signaling in stem cell self-renewal, cell polarity, body-axis specification, wound healing, and other aspects of normal development and physiology are also covered.

This volume includes discussion of Wnt signaling in cancer, skeletal defects, neurological disorders, and other human disease states. Thus, it is an indispensable reference for cell and developmental biologists as well as those, especially in the fields of stem cell biology and regenerative medicine, who are interested in targeting the Wnt pathway for therapeutic purposes.

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Parkinson's Disease

Edited By Serge Przedborski, Columbia University

© 2012 • 406 pp., illus. (36 4C images and 19 B&W), index
Hardcover • $135 • ISBN 978-1-936113-32-3

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Basic Stereology for Biologists and Neuroscientists

By Mark J. West, University of Aarhus, Denmark

© 2012 • 206 pp., illus., index
Hardcover • $69 • ISBN 978-1-936113-60-6

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Protein Synthesis and Translational Control

Edited By John W.B. Hershey, University of California, Davis; Nahum Sonenberg, McGill University; Michael B. Mathews, New Jersey Medical School, University of Medicine and Dentistry of New Jersey

© 2012 • 352 pp., illustrations, index
Hardcover • $135 • ISBN 978-1-936113-46-0

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Type 1 Diabetes

Edited By Jeffrey A. Bluestone, University of California at San Francisco; Mark A. Atkinson, University of Florida, College of Medicine; Peter R. Arvan, University of Michigan Health System

© 2012 • 305 pp., illus., index
Hardcover • $135 • ISBN 978-1-936113-21-7

Type 1 diabetes, also known as juvenile-onset or insulin-dependent diabetes mellitus (IDDM), is caused by destruction of insulin-producing β cells in the pancreas by the body’s immune system. It affects hundreds of thousands of individuals worldwide, requiring regular insulin injections to control blood glucose levels and avoid severe consequences of glucose dysregulation. Written by experts in the field, this book provides a detailed examination of our understanding of the disease process and its causes, as well as genetic risk factors, animal models of diabetes, and new treatment strategies that are being developed.

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The Synapse

Edited By Morgan Sheng, Genentech, Department of Neuroscience; Bernardo Sabatini, Harvard Medical School; Thomas C. Südhof, Stanford University School of Medicine

© 2012 • 397 pp., illus. (78 4C and 6 B&W images), index
Hardcover • $135 • ISBN 978-1-936113-02-6

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Molecular Cloning: A Laboratory Manual
(Fourth Edition)

By Michael R. Green, Howard Hughes Medical Institute, University of Massachusetts Medical School; Joseph Sambrook, Peter MacCallum Cancer Institute, Melbourne, Australia

© 2012 • 2,028 pp., illus., appendices, index
Paperback (three-volume set) • $365 $255.50 • ISBN 978-1-936113-42-2

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Molecular Cloning: A Laboratory Manual
(Fourth Edition)

By Michael R. Green, Howard Hughes Medical Institute, University of Massachusetts Medical School; Joseph Sambrook, Peter MacCallum Cancer Institute, Melbourne, Australia

© 2012 • 2,028 pp., illus., appendices, index
Cloth (three-volume set) • $475 $380.00 • ISBN 978-1-936113-41-5

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Lab Dynamics: Management and Leadership Skills for Scientists, Second Edition

By Carl M. Cohen, Science Management Associates, Newton, Massachusetts; Suzanne L. Cohen, Science Management Associates, Newton, Massachusetts

© 2012 • 280 pp., illus., index
Hardcover • $59 $41.30 • ISBN 978-1-936113-78-1