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The TGF-β Family
(Cold Spring Harbor Monograph Series 50)

Edited By Rik Derynck, University of California, San Francisco; Kohei Miyazono, University of Tokyo

© 2008 • 1,114 pp., illus., index
Hardcover • $135 $67.50 • ISBN 978-087969752-5

TGF-β is the prototype of a protein superfamily which, in humans, contains at least 35 members, including activins, inhibins, bone morphogenetic proteins, growth/differentiation factors, and Müllerian inhibiting substance. This monograph draws on the world’s leading laboratories to comprehensively cover all aspects of the biology of TGF-β and serve as a reference work for both specialists and researchers less familiar with the field.

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Adult Neurogenesis
(Cold Spring Harbor Monograph Series 52)

Edited By Fred H. Gage, The Salk Institute for Biological Studies, San Diego, California; Gerd Kempermann, Center for Regenerative Therapies, Dresden, Germany; Hongjun Song, Johns Hopkins School of Medicine, Baltimore, Maryland

© 2008 • 673 pp., illus, index
Hardcover • $135 $67.50 • ISBN 978-087969784-6

The idea that the adult brain of mammals can generate new neurons has only recently been accepted by the scientific community, and research in this exciting area is now in full swing. Bringing together leading researchers in the field of adult neurogenesis, the 30 chapters in this monograph provide a valuable overview of this emerging field and lay the groundwork for future studies. Adult Neurogenesis includes discussions on neural stem cell biology; methods and models for studying adult neurogenesis; physiological and molecular processes and their control; related neurological diseases; and comparisons of neurogenesis in humans, birds, fish, and invertebrates. It will be of interest to all researchers in neurobiology as well as those in the medical field, as it has implications for understanding depression, epilepsy, and other psychiatric disorders.

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Clocks and Rhythms
(Cold Spring Harbor Symposia on Quantitative Biology LXXII)

Edited By Bruce Stillman, Cold Spring Harbor Laboratory; David Stewart, Cold Spring Harbor Laboratory; Terri Grodzicker, Cold Spring Harbor Laboratory

© 2007 • 674 pp., illus., indexes
(Hardcover edition includes online access; call for information and registration)
Hardcover • $310 $155.00 • ISBN 978-087969822-5

Based on presentations by world-renowned investigators at the 72nd annual Cold Spring Harbor Symposium on Quantitative Biology, this volume reviews the latest advances in biological clocks and rhythms. Topics include genetic and cellular studies aimed at characterizing circadian mechanisms; systems approaches to understanding physiological, endocrine, and neural networks; and models used for studying mental and physical cycles. A variety of normal and abnormal chronobiological patterns are discussed, including sleep, aging, migration, hibernation, seasonality, depression, and arrhythmias.

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Invertebrate Neurobiology
(Cold Spring Harbor Monograph Series 49)

Edited By Geoffrey North, Editor of Current Biology; Ralph J. Greenspan, The Neurosciences Institute, San Diego, California

© 2007 • 665 pp., illus., index
Hardcover • $135 $33.75 • ISBN 978-087969819-5

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An Introduction to Nervous Systems

By Ralph J. Greenspan, The Neurosciences Institute, San Diego, California

© 2007 • 172 pp., illus., bibliography, glossary, index
Paperback • $46.00 • ISBN 978-087969821-8

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An Introduction to Nervous Systems

By Ralph J. Greenspan, The Neurosciences Institute, San Diego, California

© 2007 • 172 pp., illus., bibliography, glossary, index
Hardcover • $67.00 $33.50 • ISBN 978-087969757-0

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Gene Transfer: Delivery and Expression of DNA and RNA, A Laboratory Manual

Edited By Theodore Friedmann, University of California, San Diego; John Rossi, Beckman Research Institute of the City of Hope, Duarte, California

© 2007 • 793 pp., illus., appendix, index
Paperback • $167 $41.75 • ISBN 978-087969765-5

Understanding gene function and regulation requires rigorous testing in live cells and organisms. Recent advances have provided a variety of new strategies for delivering DNA and RNA into cells and probing their expression, as well as new clinical applications that rely upon the introduction of genetic material. The vast number of available techniques for clinical and laboratory research often makes selecting the optimal method a difficult process. Gene Transfer: Delivery and Expression of DNA and RNA provides the first comprehensive guide to technical approaches for delivering nucleic acids into cells and organisms and of ensuring (even manipulating) appropriate expression. The detailed, step-by-step protocols cover a variety of methods, both well established and newly evolving. These include viral and nonviral methods of gene delivery, transgenic approaches, strategies for the regulation of transgene expression, and modification of the host response. The introductory matter to each chapter includes concise technical and theoretical discussions with considerations for selection of the appropriate system and strategies for delivery.

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Gene Transfer: Delivery and Expression of DNA and RNA, A Laboratory Manual

Edited By Theodore Friedmann, University of California, San Diego; John Rossi, Beckman Research Institute of the City of Hope, Duarte, California

© 2007 • 793 pp., illus., appendix, index
Hardcover • $263 $65.75 • ISBN 978-087969764-8

Understanding gene function and regulation requires rigorous testing in live cells and organisms. Recent advances have provided a variety of new strategies for delivering DNA and RNA into cells and probing their expression, as well as new clinical applications that rely upon the introduction of genetic material. The vast number of available techniques for clinical and laboratory research often makes selecting the optimal method a difficult process. Gene Transfer: Delivery and Expression of DNA and RNA provides the first comprehensive guide to technical approaches for delivering nucleic acids into cells and organisms and of ensuring (even manipulating) appropriate expression. The detailed, step-by-step protocols cover a variety of methods, both well established and newly evolving. These include viral and nonviral methods of gene delivery, transgenic approaches, strategies for the regulation of transgene expression, and modification of the host response. The introductory matter to each chapter includes concise technical and theoretical discussions with considerations for selection of the appropriate system and strategies for delivery.

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Experimental Design for Biologists

By David J. Glass, M.D., Novartis Institutes for Biomedical Research, Cambridge, Massachusetts

© 2007 • 206 pp., illus., index
Hardcover • $37.00 $25.90 • ISBN 978-087969735-8

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From a to α: Yeast as a Model for Cellular Differentiation

By Hiten D. Madhani, University of California, San Francisco

© 2007 • 115 pp., illus., index
Paperback • $45 $22.50 • ISBN 978-087969738-9