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Molecular Cloning: A Laboratory Manual
(Fourth Edition)

By Michael R. Green, Howard Hughes Medical Institute, University of Massachusetts Medical School; Joseph Sambrook, Peter MacCallum Cancer Institute, Melbourne, Australia

© 2012 • 2,028 pp., illus., appendices, index
Cloth (three-volume set) • $475 $380.00 • ISBN 978-1-936113-41-5

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Extracellular Matrix Biology

Edited By Richard O. Hynes, Massachusetts Institute of Technology; Kenneth M. Yamada, National Institutes of Health

© 2012 • 387 pp., illus. (62 4C and 5 B&W), index
Hardcover • $135 • ISBN 978-1-936113-38-5

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Metabolism and Disease
(Cold Spring Harbor Symposia on Quantitative Biology LXXVI)

Edited By Terri Grodzicker, Cold Spring Harbor Laboratory; Bruce Stillman, Cold Spring Harbor Laboratory; David Stewart, Cold Spring Harbor Laboratory

© 2011 • 422 pp., illus., index
(Paperback edition does not include online access)
Paperback • $129 • ISBN 978-1-936113-57-6

This volume is based on presentations by world-renowned investigators who gathered at the 76th Cold Spring Harbor Symposium on Quantitative Biology. It reviews the latest advances in our understanding of metabolism and disease, including research on fat, exercise and rhythms; insulin resistance and sensitivity; lifespan, aging and cancer; regulation and dysregulation of metabolism; signaling and gene regulation; environment and sensing; metabolic reprogramming; clocks and intermediary metabolism; metabolism and cancer; and autophagy, timing and small RNAs.

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Metabolism and Disease

Edited By Terri Grodzicker, Cold Spring Harbor Laboratory; Bruce Stillman, Cold Spring Harbor Laboratory; David Stewart, Cold Spring Harbor Laboratory

© 2011 • 422 pp., illus., index
(Hardcover edition includes online access; call for information and registration)
Hardcover • $318 • ISBN 978-1-936113-56-9

This volume is based on presentations by world-renowned investigators who gathered at the 76th Cold Spring Harbor Symposium on Quantitative Biology. It reviews the latest advances in our understanding of metabolism and disease, including research on fat, exercise and rhythms; insulin resistance and sensitivity; lifespan, aging and cancer; regulation and dysregulation of metabolism; signaling and gene regulation; environment and sensing; metabolic reprogramming; clocks and intermediary metabolism; metabolism and cancer; and autophagy, timing and small RNAs.

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The Biology of Alzheimer Disease

Edited By Dennis J. Selkoe, Harvard Medical School; Eckhard Mandelkow, Max-Planck-Unit for Structural Molecular Biology; David M. Holtzman, Washington University School of Medicine

© 2011 • 511 pp., illus. (63 4C & 9 B&W), index
Hardcover • $135 • ISBN 978-1-936113-44-6

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Germ Cells

Edited By Paolo Sassone-Corsi, University of California, Irvine; Margaret T. Fuller, Stanford University; Robert Braun,  Jackson Laboratory

© 2011 • 222 pp., illus. (26 4C and 12 B&W images), index
Hardcover • $135 • ISBN 978-1-936113-51-4

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RNA: Life's Indispensable Molecule

By James Darnell, The Rockefeller University

© 2011 • 416 pp., illus., appendix, index
Hardcover • $40.00 • ISBN 978-1-936113-19-4

In RNA: Life’s Indispensable Molecule, Jim Darnell provides a comprehensive and captivating account of RNA research, illuminated by his own life-long and celebrated engagement in the field. Darnell describes how scientists unraveled fundamental questions about the biochemical and genetic importance of RNA—how mRNAs are generated and used to produce proteins, how noncoding and catalytic RNAs mediate key cellular processes, and how RNA molecules likely initiated life on Earth. With a scope extending from the early 20th century to the present day, and with the clarity expected from an accomplished textbook author, he conveys the intellectual context in which these questions first arose and explains how the key experiments were structured and answers obtained. The book is geared towards scientists from the graduate level on up, and will particularly appeal to active investigators in RNA biology, educators of molecular biology and biochemistry, and science historians.

About the Author

James E. Darnell, Jr., M.D. has been Vincent Astor Professor at The Rockefeller University since 1974. His career has included poliovirus research with Harry Eagle at the National Institutes of Health, research with François Jacob at the Pasteur Institute in Paris, and academic appointments at the Massachusetts Institute of Technology, Albert Einstein College of Medicine, and Columbia University. He has mentored over 120 doctoral students and postdoctoral scientists. From the very beginning of his first lab at MIT, Darnell, his students and postdocs have studied RNA, its synthesis, processing, and transcriptional regulation.

Darnell is a member of the National Academy of Sciences and has received numerous awards, including the 2003 National Medal of Science and the 2002 Albert Lasker Award for Special Achievement in Medical Science. He is the coauthor, with S.E. Luria, of General Virology (Wiley) and the founding author with Harvey Lodish and David Baltimore of Molecular Cell Biology

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Yeast Intermediary Metabolism

By Dan G. Fraenkel, Harvard Medical School

© 2011 • 434 pp., illus. (138 b/w), appendix, index
Hardcover • $128 • ISBN 978-0-879697-97-6

The intermediary metabolism of small molecules is the meat and potatoes of cell function. The pathways and modes of obtaining energy, degradation and utilization of exogenous organic nutrients, and formation of the building blocks of the main macromolecules were a major focus of research in biology from the turn of the 20th century into the 1970s. Other matters have come to prominence, but the field is active, with interesting problems that are central to biology and medicine. Molecular biology developed through the use of one bacterium, Eschericha coli, with the saying “What’s true for E. coli is true for elephants.” In recent years, an analogous workhorse has been the eukaryotic microbe baker’s yeast, Saccharomyces cerevisiae, used in many studies of cell biology common to multicellular organisms. This book explains metabolism as based on Saccharomyces. The topics include central metabolic pathways; catabolism; fermentation; respiration; biosynthesis of small molecules including cofactors; the metabolism of lipids, polysaccharides, and storage molecules; inorganic ions; transport and compartments; the global analysis of metabolism; and issues of metabolic toxicity. It can be used in courses and as a reference book for research investigators.

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Means to an End: Apoptosis and Other Cell Death Mechanisms

By Douglas R. Green, St. Jude Children’s Research Hospital

© 2011 • 220 pp., additional reading, index
Paperback • $46.00 • ISBN 978-0-879698-88-1

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Means to an End: Apoptosis and Other Cell Death Mechanisms

By Douglas R. Green, St. Jude Children’s Research Hospital

© 2011 • 220 pp., additional reading, index
Hardcover • $81.00 • ISBN 978-0-879698-87-4