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The Endoplasmic Reticulum

Edited By Susan Ferro-Novick, University of California, San Diego; Tom A. Rapoport, Harvard Medical School; Randy Schekman, University of California at Berkeley

© 2013 • 336 pp., illus (61 4C, 9 B&W), index
Hardcover • $135 • ISBN 978-1-936113-82-8

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Wnt Signaling

Edited By Roel Nusse, Stanford University Medical Center; Xi He, Children’s Hospital Boston; Renée van Amerongen, Stanford University Medical Center

© 2013 • 454 pp., illus. (75 4C and 6 B&W), index
Hardcover • $135 • ISBN 978-1-936113-23-1

Wnt proteins are signaling molecules that play critical roles during embryonic development and in the regeneration of adult tissues. They bind to Frizzled and LRP family receptors on the cell surface, triggering a series of events that cause β-catenin to enter the nucleus and activate transcription factors that control cell fate and cell proliferation. Mutations in components of the Wnt pathway lead to developmental defects and are common in cancer.

Written and edited by experts in the field, this collection from Cold Spring Harbor Perspectives in Biology covers all aspects of canonical Wnt signaling, as well as β-catenin-independent Wnt signaling and cross-talk with other pathways. The contributors examine the numerous Wnt ligands; their production, secretion, and interactions with components of the extracellular environment; and details of the downstream signaling pathways that mediate the effects of Wnt proteins on cells. The roles of Wnt signaling in stem cell self-renewal, cell polarity, body-axis specification, wound healing, and other aspects of normal development and physiology are also covered.

This volume includes discussion of Wnt signaling in cancer, skeletal defects, neurological disorders, and other human disease states. Thus, it is an indispensable reference for cell and developmental biologists as well as those, especially in the fields of stem cell biology and regenerative medicine, who are interested in targeting the Wnt pathway for therapeutic purposes.

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Angiogenesis: Biology and Pathology

Edited By Michael Klagsbrun, Children's Hospital Boston; Patricia D'Amore, Schepens Eye Research Institute

© 2011 • 522 pp., illus. (62 4C and 11 B&W), index
Hardcover • $135 • ISBN 978-1-936113-43-9

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The Mammary Gland as an Experimental Model

Edited By Mina J. Bissell, Lawrence Berkeley National Laboratory; Kornelia Polyak, Harvard Medical School; Jeffrey M. Rosen, Baylor College of Medicine

© 2011 • 325 pp., illus. (54 color, 5 b/w), index
Hardcover • $135 • ISBN 978-0-879699-06-2

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Incurable: A Life after Diagnosis

By Charles Harris

© 2011 • 280 pp., illus.
Hardcover • $31.00 • ISBN 978-1-936113-10-1

In March 2009, during a routine medical exam, Charles Harris learned that he had incurable cancer. Although a private man, he began a blog to keep family and friends current on his progress, and found a wider audience. From the blog was born Incurable, an account of a man’s struggle to live vibrantly and with courage in the face of a fatal illness. An entrepreneur and investor by profession, Charles Harris writes about living and dying, friendship and fellowship, sports and wine, race horses and recessions. His style is optimistic, direct, humorous, and companionable. Readers will find his voice brave, inspirational, and an eloquent reminder that an understanding of cancer remains an urgent goal in biomedicine. Proceeds from this book will be used by the Harris family in support of cancer research.

Read more about the book here.

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Means to an End: Apoptosis and Other Cell Death Mechanisms

By Douglas R. Green, St. Jude Children’s Research Hospital

© 2011 • 220 pp., additional reading, index
Paperback • $46.00 • ISBN 978-0-879698-88-1

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Means to an End: Apoptosis and Other Cell Death Mechanisms

By Douglas R. Green, St. Jude Children’s Research Hospital

© 2011 • 220 pp., additional reading, index
Hardcover • $81.00 • ISBN 978-0-879698-87-4

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Nuclear Organization and Function
(Cold Spring Harbor Symposia on Quantitative Biology LXXV)

Edited By Terri Grodzicker, Cold Spring Harbor Laboratory; David Spector, Cold Spring Harbor Laboratory; David Stewart, Cold Spring Harbor Laboratory; Bruce Stillman, Cold Spring Harbor Laboratory

© 2010 • 630 pp., illus. (202 color, 74 b&w)
(Paperback edition does not include online access)
Paperback • $129.00 • ISBN 978-1-936113-08-8

This volume is based on presentations by the world-renowned investigators who gathered at the 75th annual Cold Spring Harbor Symposium on Quantitative Biology to discuss the organization and function of the cell nucleus. It reviews the latest advances in research into nuclear structure, the organization of the genome within the nucleus, and spatiotemporal coordination of nuclear processes. The topics examined include nuclear domains, chromatin organization, transcription and RNA processing, DNA replication, nuclear reprogramming, and epigenetics. Cancer, premature aging syndromes, and other diseases that may be associated with altered nuclear organization are also covered.

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Nuclear Organization and Function
(Cold Spring Harbor Symposia on Quantitative Biology LXXV)

Edited By Terri Grodzicker, Cold Spring Harbor Laboratory; David Spector, Cold Spring Harbor Laboratory; David Stewart, Cold Spring Harbor Laboratory; Bruce Stillman, Cold Spring Harbor Laboratory

© 2010 • 630 pp., illus. (202 color, 74 b&w), indexes
(Hardcover edition includes online access; call for information and registration)
Hardcover • $318.00 • ISBN 978-1-936113-07-1

This volume is based on presentations by the world-renowned investigators who gathered at the 75th annual Cold Spring Harbor Symposium on Quantitative Biology to discuss the organization and function of the cell nucleus. It reviews the latest advances in research into nuclear structure, the organization of the genome within the nucleus, and spatiotemporal coordination of nuclear processes. The topics examined include nuclear domains, chromatin organization, transcription and RNA processing, DNA replication, nuclear reprogramming, and epigenetics. Cancer, premature aging syndromes, and other diseases that may be associated with altered nuclear organization are also covered.

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The p53 Family

Edited By Arnold J. Levine, Institute for Advanced Study, Princeton; David P. Lane, A *Star (Agency for Science, Technology and Research), Singapore

© 2010 • 360 pp., illus. (48 color, 19 b/w), index
Trim size: 7” x 10”
Hardcover • $135 • ISBN 978-0-879698-30-0