Cold Spring Harbor Lab Press Books

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Generation and Interpretation of Morphogen Gradients

Edited By James Briscoe, MRC National Institute for Medical Research; Peter A. Lawrence, University of Cambridge, and MRC Laboratory of Molecular Biology; Jean-Paul Vincent, MRC National Institute for Medical Research

Signaling by diffusible morphogens, such as Hedgehog, Wingless, TGF-β, and various growth factors, is essential during embryogenesis. The establishment of concentration gradients of these morphogens is vital for developmental patterning, ensuring that distinct differentiated cell types appear in the right place and at the right time in forming tissues.

Written and edited by experts in the field, this volume explores how morphogen gradients are generated and interpreted during development. The contributors examine the regulation of morphogen synthesis, trafficking, and diffusion, as well as the complex webs of signaling mechanisms and transcriptional responses in recipient cells — whose fates are dictated by these morphogens. Including discussion of the roles of morphogen gradients in various tissues in organisms from yeast to humans, the volume is a vital reference for developmental biologists and cell biologists wishing to know how cell fate is determined during embryogenesis.

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Genes, Girls, and Gamow: After the Double Helix

By James D. Watson, Cold Spring Harbor Laboratory

© 2001 • 336 pp., 43 illus., 22 letters
NOTE: For distribution in the United States and Canada only.
Hardcover • ~~$53~~ $26.50 • ISBN 978-037541283-7

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A Genetic Switch, Third Edition, Phage Lambda Revisited

By Mark Ptashne, Sloan-Kettering Memorial Cancer Center, New York

The first edition of Mark Ptashne's 1986 book describing the principles of gene regulation in phage lambda became a classic in both content and form, setting a standard of clarity and precise prose that has rarely been bettered. This edition is a reprint of the original text, together with a new chapter updating the story to 2004. Among the striking new developments are recent findings on long–range interactions between proteins bound to widely separated sites on the phage genome, and a detailed description of how gene activation works.

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Genetic Variation: A Laboratory Manual

Edited By Michael P. Weiner, RainDance Technologies, Inc., Guilford, Connecticut; Stacey B. Gabriel, The Broad Institute, Massachusetts Institute of Technology, Cambridge; J. Claiborne Stephens, Motif BioSciences, New York

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Genetics of Complex Human Diseases: A Laboratory Manual

Edited By Ammar Al-Chalabi, MRC Centre for Neurodegeneration Research, King’s College London; Laura Almasy, Southwest Foundation for Biomedical Research, San Antonio, Texas

Many human diseases—including Alzheimer’s disease, schizophrenia, cancer, and cardiovascular disease—show complex inheritance that requires sophisticated analysis. Genetics of Complex Human Diseases: A Laboratory Manual brings together the tools that geneticists use to find disease genes with the genetic concepts and statistical theories that underpin these research approaches. Topics covered include basic genetics and Mendelian inheritance, statistical methods, genetic epidemiology, linkage studies, transmission disequilibrium test analysis, variance components analysis, genome-wide association studies, copy-number variation, methods for high-throughput genotyping, the complexity of RNA editing, and genetic computer programs. The book’s chapters, written by leading investigators in the field, blend practical information and reviews of each topic, providing both the how and the why of complex disease analysis. Genetics of Complex Human Diseases is an important guide for anyone with an interest in human genetics or who uses genetic techniques in the study of diseases with complex inheritance.

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Genome Science: A Practical and Conceptual Introduction to Molecular Genetic Analysis in Eukaryotes

By David Micklos, Cold Spring Harbor Laboratory; Bruce Nash, Cold Spring Harbor Laboratory; Uwe Hilgert, University of Arizona

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Genomes
(Cold Spring Harbor Monograph Series 46)

Edited By Hillary E. Sussman, Cold Spring Harbor Laboratory; Maria A. Smit, Cold Spring Harbor Laboratory

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Genomes
(Cold Spring Harbor Monograph Series 46)

Edited By Hillary E. Sussman, Cold Spring Harbor Laboratory; Maria A. Smit, Cold Spring Harbor Laboratory

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George Beadle, An Uncommon Farmer: The Emergence of Genetics in the 20th Century

By Paul Berg, Stanford University School of Medicine; Maxine Singer, Carnegie Institution of Washington

George Beadle was a towering scientific figure whose work from the 1930s to 1960 marked the transition from classical genetics to the molecular era. Among other distinctions, he made the pivotal, Nobel Prize–winning discovery with Edward Tatum that the role of genes is to specify proteins. From 1946 to 1960 he led the Caltech Biology Division, rebuilding it to a powerhouse in molecular biology, and afterwards became a successful President of the University of Chicago. This is the first biography of a giant of genetics, written by two of the field's most distinguished contributors, Paul Berg and Maxine Singer.

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Germ Cells

Edited By Paolo Sassone-Corsi, University of California, Irvine; Margaret T. Fuller, Stanford University; Robert Braun, Jackson Laboratory

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Germ Zappers
(Enjoy Your Cells Series 2)

By Fran Balkwill; Mic Rolph

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Germ Zappers
(Enjoy Your Cells Series 2)

By Fran Balkwill; Mic Rolph

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The Golgi

Edited By Graham Warren, University of Vienna; James Rothman, Yale University

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Grounds for Knowledge
A Guide to Cold Spring Harbor Laboratory’s Landscapes and Buildings
Introducing the Bungtown Botanical Garden

By Elizabeth L. Watson; Landscape Photography by Peter Stahl

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Guide to the Human Genome

By Stewart Scherer

Presenting the genes of the human genome in their biological context, Guide to the Human Genome is an extensive online resource (also available in print) that provides easy access to information about human genes and their roles in specific processes. With numerous illustrations and tables, each of the nearly 300 sections of the Guide describes genes involved in a specific pathway, process, or structure—from the molecular and cellular levels to developmental and physiological processes. In the online version, these sections contain links to more information about proteins encoded by over 17,000 known or predicted human genes. For each protein, basic characteristics about its composition and length, its human relatives and relatedness to proteins in other species, and direct links to resources at NCBI are included. Additional links to NCBI resources are provided for human noncoding RNAs and repeated DNA elements and for proteins of interest from other species. The entire text of the Guide is searchable, and tools are available for identifying human protein sequences using those from other species. The Guide will be useful to researchers looking to connect sequence data with functional information, and can be used in parallel with traditional texts in undergraduate and graduate courses to provide a genomics dimension and experience of identifying genes underpinning processes of interest.

Have a Nice DNA
(Enjoy Your Cells Series 3)

By Fran Balkwill; Mic Rolph

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Hemoglobin and Its Diseases

Edited By David Weatherall, Weatherall Institute of Molecular Medicine; Alan N. Schechter, National Institutes of Diabetes and Digestive and Kidney Disease of the National Institutes of Health; David G. Nathan, Dana-Farber Cancer Institute

Due June 2013 • 445 pp., illus. (66 4C, 19 B&W). index
Hardcover • ~~$135~~ $101.25 • ISBN 978-1-936113-45-3

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A History of Genetics

By A.H. Sturtevant, California Institute of Technology
With a New Introduction by Edward B. Lewis

© 2001 • 174 pp., illus., appendices, bibliography, index
This book has been produced using print on demand technology.
Paperback • $21.00 • ISBN 978-087969607-8

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HIV: From Biology to Prevention and Treatment

Edited By Frederic D. Bushman, University of Pennsylvania School of Medicine; Gary J. Nabel, NIAID, National Institutes of Health; Ronald Swanstrom, University of North Carolina at Chapel Hill

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The Honest Look

By Jennifer L. Rohn

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I Wish I'd Made You Angry Earlier: Essays on Science, Scientists, and Humanity

By Max F. Perutz, formerly Chairman and Member of the MRC Laboratory of Molecular Biology, Cambridge, England

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Illuminating Life: Selected Papers from Cold Spring Harbor, Volume 1 (1903–1969)

By Jan Witkowski, Cold Spring Harbor Laboratory

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Imaging in Developmental Biology: A Laboratory Manual

Edited By James Sharpe, EMBL-CRG Systems Biology Unit, Barcelona, Spain; Rachel Wong, University of Washington; Series Editor, Rafael Yuste, Howard Hughes Medical Institute, Columbia University

New imaging technologies have revolutionized the study of developmental biology. Where researchers once struggled to connect events at static timepoints, imaging tools now offer the ability to visualize the dynamic form and function of molecules, cells, tissues, and whole embryos throughout the entire developmental process. Imaging in Developmental Biology: A Laboratory Manual, a new volume in Cold Spring Harbor Laboratory Press’ Imaging series, presents a comprehensive set of essential visualization methods. The manual features primers on live imaging of a variety of standard model organisms including C. elegans, Drosophila, zebrafish, Xenopus, avian species, and mouse. Further techniques are organized by the level of visualization they provide, from cells to tissues and organs to whole embryos. Methods range from the basics of labeling cells to cutting-edge protocols for high-speed imaging, optical projection tomography, and digital scanned laser light-sheet fluorescence. Imaging has become a required methodology for developmental biologists, and Imaging in Developmental Biology: A Laboratory Manual provides the detailed explanations and instructions for mastering these necessary techniques.

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Imaging in Neuroscience: A Laboratory Manual

Edited By Fritjof Helmchen, Brain Research Institute, University of Zurich, Switzerland; Arthur Konnerth, Institute for Neurosciences, Technical University Munich, Germany; Series Editor, Rafael Yuste, Howard Hughes Medical Institute, Columbia University

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Imaging: A Laboratory Manual

Edited By Rafael Yuste, Howard Hughes Medical Institute, Columbia University

© 2011 • 952 pp., illus. (182 color, 97 b/w), appendices, index
Trim size: 8-1/2” x 10-7/8”
Hardcover • ~~$246.00~~ $172.20 • ISBN 978-0-879699-35-2

In recent years, imaging has rapidly become a tremendously valuable approach in nearly every field of biological research. Finding the right method and optimizing it for data collection can be a daunting process, even for an established imaging laboratory. Imaging: A Laboratory Manual is the cornerstone of a new laboratory manual series, designed as an essential guide for investigators who need these visualization techniques. This first volume is meant as a general reference for all fields, and describes the theory and practice of a wide array of imaging methods. From the basic chapters on optics, equipment and labeling to detailed explanations of advanced, cutting-edge methods like PALM, STORM, light sheet and high speed microscopy, Imaging: A Laboratory Manual is a vital resource for the modern biology laboratory.

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Imaging: A Laboratory Manual

Edited By Rafael Yuste, Howard Hughes Medical Institute, Columbia University

© 2011 • 952 pp., illus. (182 color, 97 b/w), appendices, index
Trim size: 8-1/2” x 10-7/8”
Paperback • ~~$169.00~~ $118.30 • ISBN 978-0-879699-36-9

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Immune Tolerance

Edited By Diane J. Mathis, Harvard Medical School; Alexander Y. Rudensky, Howard Hughes Medical Institute and Memorial Sloan-Kettering Cancer Center

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Immunoreceptor Signaling

Edited By Lawrence E. Samelson, National Institutes of Health; Andrey Shaw, Washington University School of Medicine

© 2011 • 282 pp., illus. (49 color, 7 b/w), index
Trim size: 7” x 10”
Hardcover • ~~$135~~ $33.75 • ISBN 978-0-879698-96-6

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Incurable: A Life after Diagnosis

By Charles Harris

In March 2009, during a routine medical exam, Charles Harris learned that he had incurable cancer. Although a private man, he began a blog to keep family and friends current on his progress, and found a wider audience. From the blog was born Incurable, an account of a man’s struggle to live vibrantly and with courage in the face of a fatal illness. An entrepreneur and investor by profession, Charles Harris writes about living and dying, friendship and fellowship, sports and wine, race horses and recessions. His style is optimistic, direct, humorous, and companionable. Readers will find his voice brave, inspirational, and an eloquent reminder that an understanding of cancer remains an urgent goal in biomedicine. Proceeds from this book will be used by the Harris family in support of cancer research.

Read more about the book here.

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The Inside Story: DNA to RNA to Protein

Edited By Jan Witkowski, Cold Spring Harbor Laboratory

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Inspiring Science: Jim Watson and the Age of DNA

Edited By John Inglis, Cold Spring Harbor Laboratory; Joseph Sambrook, Peter MacCallum Cancer Centre; Jan A. Witkowski, Banbury Center, Cold Spring Harbor Laboratory

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Introduction to Protein-DNA Interactions: Structure, Thermodynamics, and Bioinformatics

By Gary D. Stormo, Ph.D.

One of the foundations of molecular biology is how the interactions of proteins with DNA control many aspects of gene expression. Since the mid-20th century, from discoveries of the lac repressor and operator and the competition between the cI and cro proteins for the same segment of DNA, we have learned an enormous amount about the interactions of proteins with DNA and their control of fundamental processes in the cell. Introduction to Protein–DNA Interactions: Structure, Thermodynamics, and Bioinformatics describes what we know about protein–DNA interactions from the complementary perspectives of molecular and structural biology and bioinformatics and how each perspective informs the others. A particular emphasis is on how insights from experimental work can be translated into specific computational approaches to create a unified view of the field and a fuller understanding of protein–DNA interactions.

Figs 3-4, 3-5, 3-6, 3-7, and 3-8 from Chapter 3

Click on the small images for a larger view.

Figure: 3-4

Figure: 3-5

Figure: 3-6

Figure: 3-7

Figure: 3-8

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Introduction to Protein-DNA Interactions: Structure, Thermodynamics, and Bioinformatics

By Gary D. Stormo, Ph.D.

Figs 3-4, 3-5, 3-6, 3-7, and 3-8 from Chapter 3

Click on the small images for a larger view.

Figure: 3-4

Figure: 3-5

Figure: 3-6

Figure: 3-7

Figure: 3-8

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Invertebrate Neurobiology
(Cold Spring Harbor Monograph Series 49)

Edited By Geoffrey North, Editor of Current Biology; Ralph J. Greenspan, The Neurosciences Institute, San Diego, California

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Is It in Your Genes? The Influence of Genes on Common Disorders and Diseases that Affect You and Your Family

By Philip R. Reilly, Interleukin Genetics

It is now clear that our risk of developing almost any disease is influenced by the genes with which we are born. One of the most important dividends of the Human Genome Project will be a much greater understanding of the influence of genes on disease and disorders in children (from asthma to autism) and adults (including heart disease, virtually all cancers, and Alzheimer's disease). The nature of genetic risks in families is becoming clearer and this book is written to help people understand them. Philip Reilly, a physician–geneticist, who has given hundreds of lectures on this subject, takes a user–friendly approach. Drawing on the many questions he has been asked (for example, “My sister has multiple sclerosis. Am I at an increased risk?”), Reilly discusses over 90 common conditions, diseases, and disorders, arranged from conception to old age. In frank, non–technical terms, he makes clear what is known and not known about the genetic factors and, if your risk is elevated, what you might be able to do about it. This book is a uniquely valuable resource for anyone seeking more information about a family’s disease heritage.

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Lab Dynamics: Management and Leadership Skills for Scientists, Second Edition

By Carl M. Cohen, Science Management Associates, Newton, Massachusetts; Suzanne L. Cohen, Science Management Associates, Newton, Massachusetts

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Lab Math: A Handbook of Measurements, Calculations, and Other Quantitative Skills for Use at the Bench

By Dany Spencer Adams, The Forsyth Institute

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Lab Math: A Handbook of Measurements, Calculations, and Other Quantitative Skills for Use at the Bench, 2nd edition

By Dany Spencer Adams

Due September 2013 • 350pp. (approx.), illus., index
Concealed wire binding • $59 • ISBN 978-1-936113-71-2

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Lab Ref, Volume 1
A Handbook of Recipes, Reagents, and Other Reference Tools for Use at the Bench

Edited By Jane Roskams, University of British Columbia, Canada; Linda Rodgers, Cold Spring Harbor Laboratory

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Lab Ref, Volume 2
A Handbook of Recipes, Reagents, and Other Reference Tools for Use at the Bench

Edited By Albert S. Mellick, Cold Spring Harbor Laboratory, New York; Linda Rodgers, Cold Spring Harbor Laboratory, New York

Like its predecessor Lab Ref, Volume 1, this book is a handy benchtop source of recipes and information needed for common laboratory protocols. Lab Ref, Volume 2 contains recipes for procedures as diverse as RNA interference, imaging, proteomics, and quantitative nucleic acid analysis, and is organized by application for quick and easy reference. All recipes were derived from recent manuals published by Cold Spring Harbor Laboratory Press, and each recipe is cross-referenced to its manual of origin. Reference tables and charts are included. To meet the growing need for computational resources in the biology laboratory, Lab Ref, Volume 2 also has an expanded Web site section with sources for biological materials, databases for acquiring and annotating genomic and proteomic data, and links to downloadable software.

View two different sets of sample pages from the book here — and here —

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Laboratory Research Notebook

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Laboratory Research Notebook

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Landmark Papers in Yeast Biology

Edited By Patrick Linder, University of Geneva; David Shore, University of Geneva; Michael N. Hall, Biozentrum, University of Basel

Yeast has been a preeminent experimental organism of genetic research for more than 50 years. Progress in the field has provided the conceptual framework that has driven experiments in many areas of biology. Landmark Papers in Yeast Biology consists of essays by prominent scientists on the context and significance of 71 carefully selected research papers, which are reprinted on the accompanying CD. The papers include early, hard–to–find classics as well as more recent advances in areas such as signal transduction, membrane trafficking, protein turnover, and genomics. This collection has unique value for all scholars of yeast and could provide the foundation for a literature–based course on molecular cell biology. As Jasper Rine notes in his eloquent introduction, the editors and contributors share the belief that “deep study of the agreed–on classics is the best training for learning how to recognize those contemporary papers worthy of our personal time....”

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Life Illuminated: Selected Papers from Cold Spring Harbor
Volume 2, 1972–1994

Edited By Jan A. Witkowski, Cold Spring Harbor Laboratory, New York; Alexander Gann, Cold Spring Harbor Laboratory, New York; Joseph F. Sambrook, Peter MacCallum Cancer Institute, East Melbourne, Australia

© 2008 • 242 pp., illustrations from original articles, indexes, CD
Hardcover • ~~$39~~ $19.50 • ISBN 978-087969804-1

This book is the second volume of an intellectual history of the science done at CSHL (the first volume, Illuminating Life, showed that genetics became the dominant theme of research at CSH by as early as 1904). The appointment of James Watson as Director of the Laboratory in 1968 set off the explosive research development at CSH, as he recruited widely and wisely teams of investigators with diverse scientific interests. From this collection of papers, presented in full on the accompanying CD, several themes emerge: the characterization and exploitation of mobile genetic elements; the mechanics of DNA replication and regulation of the cell cycle; the behavior and internal architecture of cells; how viruses induce tumors; the discovery of cancer genes; the characteristics of neurons; and the invention of techniques that make possible further progress. Each theme is introduced in the context of the science of the time, and each paper has a commentary by, in most cases, one of its authors. Life Illuminated is a story of scientific innovation and achievement, told in the words of the investigators themselves.

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Live Cell Imaging: A Laboratory Manual, Second Edition

Edited By Robert D. Goldman, Feinberg School of Medicine Northwestern University; Jason R. Swedlow, The University of Dundee; David L. Spector, Cold Spring Harbor Laboratory

The second edition of Live Cell Imaging: A Laboratory Manual expands upon and extends the collection of established and evolving methods for studying dynamic changes in living cells and organisms presented in the well-known first edition. There are 16 new chapters and the 21 updated chapters in this new edition. They include advances in atomic force microscopy, structured illumination microscopy and other 3-D approaches, as well as imaging in single cells in animals and in plants. New analytical options include live high-throughput/high-content screening in mammalian cells and computational analysis of live cell data. The manual presents hands-on techniques as well as background material, and can serve as a text in advanced courses. The first section covers principles and fundamental issues of detection and imaging; the second provides detailed protocols for imaging live systems.

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Mammalian Development: Networks, Switches, and Morphogenetic Processes

Edited By Patrick P.L. Tam, Children’s Medical Research Institute; W. James Nelson, Stanford University; Janet Rossant, The Hospital for Sick Children

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The Mammary Gland as an Experimental Model

Edited By Mina J. Bissell, Lawrence Berkeley National Laboratory; Kornelia Polyak, Harvard Medical School; Jeffrey M. Rosen, Baylor College of Medicine

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Manipulating the Mouse Embryo: A Laboratory Manual (Third Edition)

By Andras Nagy, Samuel Lunenfeld Research Institute; Marina Gertsenstein, Samuel Lunenfeld Research Institute; Kristina Vintersten, European Molecular Biology Laboratory; Richard Behringer, University of Texas M.D. Anderson Cancer Center

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Max Perutz and the Secret of Life

By Georgina Ferry

© 2007 • 352 pp., illus., glossary, index
All orders from outside of the United States, Europe, and China must be directed to Chatto and Windus, an imprint of Random House at www.randomhouse.co.uk/chatto/

Don’t miss the new podcast and online slideshow featuring Georgina Ferry discussing her book and Max Perutz.

Hardcover • $40.00 • ISBN 978-087969785-3

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Means to an End: Apoptosis and Other Cell Death Mechanisms

By Douglas R. Green, St. Jude Children’s Research Hospital

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Means to an End: Apoptosis and Other Cell Death Mechanisms

By Douglas R. Green, St. Jude Children’s Research Hospital

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Mendel's Legacy: The Origin of Classical Genetics

By Elof Axel Carlson, Professor Emeritus, State University of New York at Stony Brook

This latest book by Elof Carlson (The Unfit) is a first history of classical genetics, the era in which the chromosome theory of heredity was proposed and developed. Highly illustrated and based heavily on early 20th century original sources, the book traces the roots of genetics in breeding analysis and studies of cytology, evolution, and reproductive biology that began in Europe but were synthesized in the United States through new Ph.D. programs and expanded academic funding. Carlson argues that, influenced largely by new technologies and instrumentation, the life sciences progressed though incremental change rather than paradigm shifts, and he describes how molecular biology emerged from the key ideas and model systems of classical genetics. Readable and original, this narrative will interest historians and science educators as well as today's practitioners of genetics.

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Metabolism and Disease
(Cold Spring Harbor Symposia on Quantitative Biology LXXVI)

Edited By Terri Grodzicker, Cold Spring Harbor Laboratory; Bruce Stillman, Cold Spring Harbor Laboratory; David Stewart, Cold Spring Harbor Laboratory

© 2011 • 422 pp., illus., index
(Paperback edition does not include online access)
Paperback • $129 • ISBN 978-1-936113-57-6

This volume is based on presentations by world-renowned investigators who gathered at the 76th Cold Spring Harbor Symposium on Quantitative Biology. It reviews the latest advances in our understanding of metabolism and disease, including research on fat, exercise and rhythms; insulin resistance and sensitivity; lifespan, aging and cancer; regulation and dysregulation of metabolism; signaling and gene regulation; environment and sensing; metabolic reprogramming; clocks and intermediary metabolism; metabolism and cancer; and autophagy, timing and small RNAs.

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Metabolism and Disease

Edited By Terri Grodzicker, Cold Spring Harbor Laboratory; Bruce Stillman, Cold Spring Harbor Laboratory; David Stewart, Cold Spring Harbor Laboratory

© 2011 • 422 pp., illus., index
(Hardcover edition includes online access; call for information and registration)
Hardcover • $318 • ISBN 978-1-936113-56-9

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Methods in Yeast Genetics: A Cold Spring Harbor Laboratory Course Manual, 2005 Edition

By David C. Amberg, Upstate Medical University, Syracuse; Daniel J. Burke, University of Virginia Medical Center, Charlottesville; Jeffrey N. Strathern, National Cancer Institute

“Methods in Yeast Genetics” is a course that has been offered annually at Cold Spring Harbor Laboratory for the last thirty years. This is an updated edition of the course manual, which provides a set of teaching experiments, along with protocols and recipes for the standard techniques and reagents used in the study of yeast biology. Since the last edition of the manual was published (2000), revolutionary advances in genomics and proteomics technologies have had a significant impact on the field. This updated edition reflects these advances, and also includes new techniques involving vital staining, visualization of Green Fluorescent Protein, new drug resistance markers, high-copy suppression, Tandem Affinity Protein tag protein purification, gene disruption by double-fusion polymerase chain reaction, and many other recent developments.

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Mitochondria

Edited By Douglas C. Wallace, Children's Hospital of Philadelphia, University of Pennsylvania; Richard J. Youle, National Institute of Neurological Disorders and Strokes, Porter Neuroscience Research Center

Due September 2013 • 300 pp.(approx.), illus., index
Hardcover • $135 • ISBN 978-1-936113-35-4

Mitochondria are intracellular organelles that power the cell by metabolizing glucose and other energy sources to generate ATP. They are also critical in programmed cell death, and dysfunction of mitochondrial components is implicated in numerous muscle and neurodegenerative disorders, including Parkinson’s disease. This volume contains contributions examining the evolution and normal function of mitochondria in cells, as well as their roles in various pathologies.

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Molecular Approaches to Controlling Cancer
(Cold Spring Harbor Symposia on Quantitative Biology LXX)

Edited By Bruce Stillman, Cold Spring Harbor Laboratory; David Stewart, Cold Spring Harbor Laboratory

© 2005 • 538 pp., illus., index
(Hardcover edition includes online access; call for information and registration)
Hardcover • ~~$310~~ $62.00 • ISBN 978-087969773-0

The 2005 Cold Spring Harbor Symposium on Quantitative Biology focused on molecular strategies aimed at understanding and controlling the cancerous state. The resulting volume, with contributions from the world’s leading laboratories, covers many aspects of cancer genetics, including DNA repair, telomeres, animal models, stem cells, and therapeutic approaches.

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© 2005 • 538 pp., illus., index
(Paperback edition does not include online access)
Paperback • ~~$126~~ $25.20 • ISBN 978-087969774-7

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Molecular Biology of Aging
(Cold Spring Harbor Monograph Series 51)

Edited By Leonard P. Guarente, Massachusetts Institute of Technology, Cambridge; Linda Partridge, University College London, UK; Douglas C. Wallace, University of California, Irvine

Research into the causes of aging, and strategies to delay that process, have gained much ground and attention in recent years. This volume covers the major threads in the molecular genetics of aging, including genes that regulate aging, causes of aging, evolutionary theories of aging, and the relationship between diet and aging. Among specific topics covered are calorie restriction, mitochondria, sirtuins, telomeres, stem cells, and cancer. Each chapter is written by one or more leaders in the field, and the book presents the current status of this exciting research area and provides an invaluable source of information in a single volume.

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Molecular Biology of the Gene, Seventh Edition

By James D. Watson, Cold Spring Harbor Laboratory; Tania A. Baker, Massachusetts Institute of Technology; Alexander Gann, Cold Spring Harbor Laboratory; Michael Levine, University of California, Berkeley; Richard Losick, Harvard University

Due February 2013 • 872 pp., illus., index
Hardcover • $Not for Sale • ISBN 978-0-321-76243-6

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Molecular Cloning: A Laboratory Manual
(Fourth Edition)

By Michael R. Green, Howard Hughes Medical Institute, University of Massachusetts Medical School; Joseph Sambrook, Peter MacCallum Cancer Institute, Melbourne, Australia

© 2012 • 2,028 pp., illus., appendices, index
Paperback (three-volume set) • ~~$365~~ $255.50 • ISBN 978-1-936113-42-2

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© 2012 • 2,028 pp., illus., appendices, index
Cloth (three-volume set) • ~~$475~~ $380.00 • ISBN 978-1-936113-41-5

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Mouse Hematology: A Laboratory Manual

By Michael P. McGarry, Department of Biochemistry and Molecular Biology, Mayo Clinic Arizona; Cheryl A. Protheroe, Department of Biochemistry and Molecular Biology, Mayo Clinic Arizona; James J. Lee, Department of Biochemistry and Molecular Biology, Mayo Clinic Arizona

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Mouse Phenotypes: A Handbook of Mutation Analysis

By Virginia E. Papaioannou, Columbia University College of Physicians and Surgeons; Richard R. Behringer, University of Texas MD Anderson Cancer Center

The generation of mutant mice raises many questions about the best means of phenotypic analysis, breeding, and maintenance. The answers are now available from two experts with a wealth of detailed knowledge never previously assembled in one volume. Informal and highly practical, this handbook provides step–by–step methods for troubleshooting experiments, from the basics of gene targeting through the analysis of postnatal effects.

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Mutation: The History of an Idea from Darwin to Genomics

By Elof Axel Carlson, Professor Emeritus, State University of New York at Stony Brook; Visiting Scholar, Institute for Advanced Study, Indiana University

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My Heart vs. the Real World: Children with Heart Disease, In Photographs & Interviews

By Max S. Gerber

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Neither Gods Nor Beasts
How Science Is Changing Who We Think We Are

By Elof A. Carlson, Emeritus, State University of New York at Stony Brook

Traditional views of human nature focus on the supernatural, defining us as creatures with souls, minds, and spirits that transcend our physical attributes. In this provocative book, distinguished scientist and historian Elof Axel Carlson argues for a different understanding of ourselves based on our biology—cellular organization, genetics, life cycle, evolution, and our origins as a species. This interpretation does not negate our capacity for imagination, spiritual and emotional yearnings, or aesthetic appreciation for art, music, and literature. Carlson challenges educators, the media, and public policy makers to integrate the evidence from science more fully into our understanding of ourselves.

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The Nematode Caenorhabditis elegans
(Cold Spring Harbor Monograph Series 17)

Edited By William B. Wood, University of Colorado, Boulder

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Neurobiology of the Leech

Edited By Kenneth J. Muller, Carnegie Institution of Washington; John G. Nicholls, Stanford University School of Medicine; Gunther S. Stent, University of California, Berkeley

In the 19th century, the medicinal applications of leeches prompted basic research into their neurobiology, reproduction, development, and anatomy; subsequently, leeches became an important model for understanding the nervous system. In this monograph, each chapter provides a narrative account of experimental work on a particular area of leech neurobiology, and explains its significance for the broader field of neuroscience. The appendices describe methods for maintaining and manipulating leeches in the laboratory and include an atlas of neurons in the leech Hirudo medicinalis. Extensively illustrated, this book is a classic in the field and is considered a “must read” for neuroscientists and those interested in leech biology. It has been out of print for many years; however, some recent inquiries have prompted us to reprint it and make it available at an affordable price.

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Neuronal Guidance: The Biology of Brain Wiring

Edited By Marc Tessier-Lavigne, The Rockefeller University; Alex L. Kolodkin, Johns Hopkins University School of Medicine

© 2011 • 397 pp., illus. (87 color, 6 b/w), index
Trim size: 7” x 10”
Hardcover • ~~$135~~ $33.75 • ISBN 978-0-879698-97-3

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Next-Generation DNA Sequencing Informatics

Edited By Stuart M. Brown, New York University School of Medicine

Next-generation DNA sequencing (NGS) technology has revolutionized biomedical research, making complete genome sequencing an affordable and frequently used tool for a wide variety of research applications. Bioinformatics methods to support DNA sequencing have become a critical bottleneck for many researchers and organizations wishing to make use of NGS technology. This book provides a thorough introduction to the necessary informatics methods and tools for operating NGS instruments and analyzing NGS data. The book also provides extensive reference to best-practice bioinformatic methods for the most commonly used NGS technologies and applications. The book also includes reference to, and guidance on, the setup and use of essential software for NGS data analysis. This is the first book of its kind to address the informatics needs of scientists who wish to take advantage of the explosion of research opportunities offered by new DNA sequencing technologies.

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NF-κB: A Network Hub Controlling Immunity, Inflammation, and Cancer

Edited By Michael Karin, University of California, San Diego; Louis M. Staudt, National Cancer Institute

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Nuclear Organization and Function
(Cold Spring Harbor Symposia on Quantitative Biology LXXV)

Edited By Terri Grodzicker, Cold Spring Harbor Laboratory; David Spector, Cold Spring Harbor Laboratory; David Stewart, Cold Spring Harbor Laboratory; Bruce Stillman, Cold Spring Harbor Laboratory

© 2010 • 630 pp., illus. (202 color, 74 b&w), indexes
(Hardcover edition includes online access; call for information and registration)
Hardcover • $318.00 • ISBN 978-1-936113-07-1

This volume is based on presentations by the world-renowned investigators who gathered at the 75th annual Cold Spring Harbor Symposium on Quantitative Biology to discuss the organization and function of the cell nucleus. It reviews the latest advances in research into nuclear structure, the organization of the genome within the nucleus, and spatiotemporal coordination of nuclear processes. The topics examined include nuclear domains, chromatin organization, transcription and RNA processing, DNA replication, nuclear reprogramming, and epigenetics. Cancer, premature aging syndromes, and other diseases that may be associated with altered nuclear organization are also covered.

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© 2010 • 630 pp., illus. (202 color, 74 b&w)
(Paperback edition does not include online access)
Paperback • $129.00 • ISBN 978-1-936113-08-8

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The Nucleus

Edited By Tom Misteli, National Cancer Institute/National Institutes of Health; David L. Spector, Cold Spring Harbor Laboratory

© 2011 • 517 pp., illus. (82 color, 17 b/w), index
Trim size: 7” x 10”
Hardcover • ~~$135~~ $33.75 • ISBN 978-0-879698-94-2

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The Origins of Life

Edited By David Deamer, University of California, Santa Cruz; Jack W. Szostak, Howard Hughes Medical Institute, Massachusetts General Hospital

© 2010 • 318 pp., illus. (47 color, 50 b/w), index
Trim size: 7” x 10”
Hardcover • ~~$135~~ $33.75 • ISBN 978-1-936113-04-0

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The p53 Family

Edited By Arnold J. Levine, Institute for Advanced Study, Princeton; David P. Lane, A *Star (Agency for Science, Technology and Research), Singapore

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Pandora's Baby: How the First Test Tube Babies Sparked the Reproductive Revolution

By Robin Marantz Henig

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Parkinson's Disease

Edited By Serge Przedborski, Columbia University

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A Passion for DNA: Genes, Genomes, and Society

By James D. Watson, Cold Spring Harbor Laboratory
With an Introduction, Afterword, and Annotations by Walter Gratzer, King’s College London

© 2001 • 266 pp., index
(Published /distributed in conjunction with Oxford University Press.
Click More INFO to find special ordering instructions.)
Paperback • $16 • ISBN 978-087969609-2

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A Passion for DNA: Genes, Genomes, and Society

By James D. Watson, Cold Spring Harbor Laboratory
With an Introduction, Afterword, and Annotations by Walter Gratzer, King’s College London

© 2000 • 250 pp., index
(Published /distributed in conjunction with Oxford University Press.
Click More INFO to find special ordering instructions.)
Cloth • $26 • ISBN 978-087969581-1

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Pattern Formation during Development
(Cold Spring Harbor Symposia on Quantitative Biology LXII)

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Phage and the Origins of Molecular Biology, The Centennial Edition

Edited By John Cairns, Cold Spring Harbor Laboratory; Gunther S. Stent, University of California, Berkeley; James D. Watson, Harvard University

This hugely influential book, published in 1966 as a 60th birthday tribute to Max Delbrück, is now republished as The Centennial Edition. On first publication, the book was hailed as “[introducing] into the literature of science, for the first time, a self–conscious historical element in which the participants in scientific discovery engage in writing their own chronicle. As such, it is an important document in the history of biology...” (Journal of History of Biology). And in another review it was described as “required reading for every student of experimental biology...[who] will sense the smell and rattle of the laboratory” (Bioscience). The book was a formative influence on many of today’s leading scientists.

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Phage Display: A Laboratory Manual

By Carlos F. Barbas III, The Scripps Research Institute; Dennis R. Burton, The Scripps Research Institute; Jamie K. Scott, Simon Fraser University; Gregg J. Silverman, University of California, San Diego

© 2001 • 736 pp., illus., index
This book has been produced using print on demand technology.
Paperback • $81.00 • ISBN 978-087969740-2

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Prion Biology and Diseases, Second Edition
(Cold Spring Harbor Monograph Series 41)

Edited By Stanley B. Prusiner, University of California, San Francisco

© 2004 • 1,050 pp., illus., color plates, glossary, appendix, index
Hardcover • ~~$147~~ $29.40 • ISBN 978-087969693-1

This volume is a new edition of the most authoritative book on Prion Biology, first published in 1999 and edited by the Nobel Prize–winning founder of the field. This expanded edition has been completely updated, and includes chapters on therapeutics, and diagnostic methods and approaches.

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Protein Homeostasis

Edited By Richard I. Morimoto, Northwestern University; Dennis J. Selkoe, Brigham and Women's Hospital; Jeffrey W. Kelly, Scripps Institute

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Protein Synthesis and Translational Control

Edited By John W.B. Hershey, University of California, Davis; Nahum Sonenberg, McGill University; Michael B. Mathews, New Jersey Medical School, University of Medicine and Dentistry of New Jersey

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Protein-Protein Interactions: A Molecular Cloning Manual, Second Edition

Edited By Erica A. Golemis, Fox Chase Cancer Center, Philadelphia; Peter D. Adams, Fox Chase Cancer Center, Philadelphia

This is an updated edition of a manual that provides a thorough collection of the technical and theoretical issues involved in the study of protein associations, including standard methods, biophysical approaches, and, in a final section, a collection of computational methods for integrating and analyzing interactions.

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Proteomics:
A Cold Spring Harbor Laboratory Course Manual

By Andrew J. Link, Vanderbilt University School of Medicine, Nashville, Tennessee; Joshua LaBaer, Harvard University School of Medicine

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Proteomics:
A Cold Spring Harbor Laboratory Course Manual

By Andrew J. Link, Vanderbilt University School of Medicine, Nashville, Tennessee; Joshua LaBaer, Harvard University School of Medicine

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Regulatory RNAs
(Cold Spring Harbor Symposia on Quantitative Biology LXXI)

Edited By Bruce Stillman, Cold Spring Harbor Laboratory, New York; David Stewart, Cold Spring Harbor Laboratory, New York

© 2006 • 574 pp., illus., indexes
(Hardcover edition includes online access; call for information and registration)
Hardcover • ~~$310~~ $155.00 • ISBN 978-087969817-1

“Regulatory RNAs” was the theme of the 71st annual Cold Spring Harbor Symposium on Quantitative Biology, where scientists from around the world presented the latest advances in the biology of RNAs, including RNA interference, transcriptional and translational control, RNA editing, and the role of RNAs in biological circuits and epigenetic events. Investigators discussed the latest technologies aimed at large-scale characterization of RNAs, as well as the roles of small RNAs in development and cancer. This volume is a timely survey of this important new area of molecular biology.

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The Ribosome
(Cold Spring Harbor Symposia on Quantitative Biology LXVI)

Edited By Bruce Stillman, Cold Spring Harbor Laboratory

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RNA Worlds: From Life’s Origins to Diversity in Gene Regulation

Edited By John F. Atkins, University of Utah, University College Cork, and Trinity College Dublin; Raymond F. Gesteland, University of Utah; Thomas R. Cech, Howard Hughes Medical Institute, University of Colorado

© 2011 • 366 pp., illus. (73 color, 23 b/w), index
Trim size: 8-1/2” x 10-7/8”
Hardcover • $162.00 • ISBN 978-0-879699-46-8

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RNA: A Laboratory Manual

By Donald C. Rio, University of California, Berkeley; Manuel Ares, Jr., University of California, Santa Cruz; Gregory J. Hannon, Cold Spring Harbor Laboratory; Timothy W. Nilsen, Case Western Reserve University School of Medicine

So much has been learned about RNA in the past 10 years that the ability to purify, analyze, and manipulate RNA molecules is now essential in all kinds of bioscience. Initiating RNA research can be intimidating, but the new book RNA: A Laboratory Manual provides a broad range of up-to-date techniques presented in a functional framework, so that any investigator can confidently handle RNA and carry out meaningful experiments, from the most basic to the highly sophisticated. Originating in four of the field's most prominent laboratories, this manual provides the necessary background and strategies for approaching any RNA investigation, as well as detailed protocols and extensive tips and troubleshooting information. It is required reading for every research laboratory in the life sciences.

About the Authors

Donald C. Rio is Professor of Molecular and Cell Biology at the University of California, Berkeley. His research has focused on nucleic acid biochemistry, nucleic acid–protein interactions, nucleic acid rearrangements, and genome-wide approaches to the role of RNA binding proteins in controlling alternative pre-mRNA splicing. Dr. Rio obtained his Ph.D. with Robert Tjian at the University of California, Berkeley and did postdoctoral work with Gerald Rubin. He was Assistant and Associate Professor at MIT and Associate Member of the Whitehead Institute for Biomedical Research, prior to moving to his current position.

Manuel Ares, Jr. is Professor of Molecular, Cell & Developmental Biology at the University of California, Santa Cruz. He received a Ph.D. with Stephen H. Howell on the cell cycle of Chlamydomonas at UC San Diego (1982) and did postdoctoral work with Alan M. Weiner on snRNA transcription in HeLa cells at Yale. He joined the faculty at UC Santa Cruz in 1987 and has focused on snRNA processing, structure, and function in yeast and mammalian cells. He is currently President of the RNA Society.

Gregory J. Hannon is Professor and Howard Hughes Medical Institute Investigator at Cold Spring Harbor Laboratory. He received his Ph.D. at Case Western Reserve University working with Tim Nilsen (1992) and then moved to Cold Spring Harbor Laboratory for postdoctoral studies with David Beach. A pioneering investigator in the field of RNA interference, his laboratory has characterized many of the major complexes for small interfering RNAs and microRNAs. His lab also investigates the role of small RNAs as oncogenes and tumor suppressors and the use of RNAi libraries to identify therapeutic targets for specific disease subtypes.

Timothy W. Nilsen is Professor and Director of the Center for RNA Molecular Biology at Case Western Reserve University School of Medicine. He is also Professor of Biochemistry and of Medicine. After receiving a Ph.D. from the State University of New York at Albany working with Corrado Baglioni, he joined the faculty at CWRU (1982). His research has focused on RNA biology including the mechanism of action of interferon, the mechanism of SL-addition trans-splicing and mechanisms of regulation of alternative splicing. Currently, his laboratory is investigating the mechanism(s) of microRNA mediated gene regulation in animal cells and the structure and function of messenger ribonucleoprotiens. Dr. Nilsen became Editor in Chief of the journal RNA when it was founded in 1995 and still serves in that capacity. He is on the Editorial Board of Molecular and Cellular Biology and the Board of Reviewing Editors for Science.

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RNA molecules participate in and regulate a vast array of cellular processes, and the scientific community is now entering a new era in which some aspect of RNA biology—as a tool, a therapeutic, a diagnostic, or part of a fundamental process—is becoming increasingly important. But initiating RNA research can be intimidating, and without a thorough understanding of the challenges and complexities inherent in handling this fragile nucleic acid, forays into the RNA world can be quite frustrating. RNA: A Laboratory Manual provides a broad range of up-to-date techniques so that any investigator can confidently handle RNA and carry out meaningful experiments, from the most basic to the most sophisticated. Originating in four of the field’s most prominent laboratories and written with novices as well as more advanced researchers in mind, this manual provides the necessary background and strategies for approaching any RNA investigation in addition to detailed step-by-step protocols and extensive tips and troubleshooting information. RNA: A Laboratory Manual will enable any researcher to approach a wide variety of RNA-related problems with confidence and a high expectation of success.

About the Authors

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RNA: Life's Indispensable Molecule

By James Darnell, The Rockefeller University

In RNA: Life’s Indispensable Molecule, Jim Darnell provides a comprehensive and captivating account of RNA research, illuminated by his own life-long and celebrated engagement in the field. Darnell describes how scientists unraveled fundamental questions about the biochemical and genetic importance of RNA—how mRNAs are generated and used to produce proteins, how noncoding and catalytic RNAs mediate key cellular processes, and how RNA molecules likely initiated life on Earth. With a scope extending from the early 20th century to the present day, and with the clarity expected from an accomplished textbook author, he conveys the intellectual context in which these questions first arose and explains how the key experiments were structured and answers obtained. The book is geared towards scientists from the graduate level on up, and will particularly appeal to active investigators in RNA biology, educators of molecular biology and biochemistry, and science historians.

About the Author

James E. Darnell, Jr., M.D. has been Vincent Astor Professor at The Rockefeller University since 1974. His career has included poliovirus research with Harry Eagle at the National Institutes of Health, research with François Jacob at the Pasteur Institute in Paris, and academic appointments at the Massachusetts Institute of Technology, Albert Einstein College of Medicine, and Columbia University. He has mentored over 120 doctoral students and postdoctoral scientists. From the very beginning of his first lab at MIT, Darnell, his students and postdocs have studied RNA, its synthesis, processing, and transcriptional regulation.

Darnell is a member of the National Academy of Sciences and has received numerous awards, including the 2003 National Medal of Science and the 2002 Albert Lasker Award for Special Achievement in Medical Science. He is the coauthor, with S.E. Luria, of General Virology (Wiley) and the founding author with Harvey Lodish and David Baltimore of Molecular Cell Biology

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RNAi: A Guide to Gene Silencing

Edited By Gregory J. Hannon, Cold Spring Harbor Laboratory

The ability of double stranded RNA to inhibit the expression of genes with an appropriate sequence can be harnessed to silence target genes in vitro in a new and powerful way. This volume combines reliable RNAi protocols for a variety of species with discussion of strategies for the effective design of experiments using this important new technique that is changing the way experimental science is done.

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RNAi: A Guide to Gene Silencing

Edited By Gregory J. Hannon, Cold Spring Harbor Laboratory

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A Short Guide to the Human Genome

By Stewart Scherer

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Signaling & Gene Expression in the Immune System
(Cold Spring Harbor Symposia on Quantitative Biology LXIV)

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Single-Molecule Techniques: A Laboratory Manual

Edited By Paul R. Selvin, University of Illinois, Urbana-Champaign; Taekjip Ha, University of Illinois, Urbana-Champaign

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The Skeletal System
(Cold Spring Harbor Monograph Series 53)

Edited By Olivier Pourquié, Stowers Institute for Medical Research, Kansas City, Missouri

The thirteen chapters presented in this book summarize our current understanding of the development, biology, and evolution of the vertebrate skeleton. Written by experts in the field, chapters cover everything from the differentiation of chondrocytes, limb and craniofacial patterning, and the origins and evolution of bone to the genetics of human skeletal disease. It is a useful reference for scientists and clinicians wishing to learn how the skeleton is built and works.

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Speaking of Genetics: A Collection of Interviews

Edited By Jane Gitschier, Institute for Human Genetics, University of California, San Francisco

These 22 interviews were conducted by University of California Professor Jane Gitschier for publication in the scientific journal PLoS Genetics over the past 5 years. Here these interviews are presented as a single, stand-alone collection for the first time.

The collection makes a compelling read by capturing exhilarating moments of discovery on a wide range of genetic questions as recounted by the scientists themselves. We also hear from scientists whose careers have taken on a broader role—a University president, a master teacher, an author, the founder of a company, and an explorer. Further perspective is provided by several non-scientists whose work helps frame our understanding and practice of genetics; these include a judge, a reporter, an administrator, and an historian of science. Together, the interviews in this collection bring to life the practice and societal implications of contemporary genetics.

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Statistics at the Bench: A Step-by-Step Handbook for Biologists

By Martina Bremer, Department of Mathematics, San Jose State University, California; Rebecca W. Doerge, Departments of Statistics and Agronomy, Purdue University, Indiana

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The Statue Within: An Autobiography

By Francois Jacob
Translated by Franklin Philip

© 1995 • 326 pp., index
This book has been produced using print on demand technology.
Paper • ~~$22~~ $11.00 • ISBN 978-087969476-0

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Strategies for Protein Purification and Characterization: A Laboratory Course Manual

By Daniel R. Marshak, Cold Spring Harbor Laboratory; Mark W. Knuth, Promega Corporation, Madison, Wisconsin

© 1996 • 396 pp., illus., appendices, index
This book has been produced using print on demand technology.
Spiral binding • $48.00 • ISBN 978-087969385-5

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The Strongest Boy in the World: How Genetic Information is Reshaping Our Lives, Updated and Expanded Edition

By Philip R. Reilly

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Sydney Brenner: A Biography

By Errol C. Friedberg, University of Texas Southwestern Medical Center at Dallas

Over his long and inspiring career, the Nobel Laureate Sydney Brenner has made some of the most significant and game-changing discoveries in the field of molecular biology. But Brenner’s reach has extended well beyond his own research to inspire new generations of young scientists and to promote the development of science and biotechnology around the world. Based on his personal recollections, with contributions and correspondence from his close friends and colleagues, this book tells the lively story, not only of Brenner himself, but of what came to be known as the “golden age” of biology.About the author: Errol C. Friedberg, M.D., is the Senator Betty and Dr. Andy Andujar Distinguished Professor and Chair at the Department of Pathology, University of Texas Southwestern Medical Center at Dallas. A Fellow of the Royal College of Pathologists and recipient of the Rous Whipple Award from the American Society for Investigative Pathology, Friedberg also serves as Editor-in-Chief of the journal DNA Repair. Friedberg is the author of Cancer Answers, Correcting the Blueprint of Life: An Historical Account of the Discovery of DNA Repair Mechanisms, The Writing Life of James D. Watson, and From Rags to Riches: The Phenomenal Rise of The University of Texas Southwestern Medical Center at Dallas. He is also senior author of the textbook DNA Repair & Mutagenesis, and has edited and annotated a series of interviews published as Sydney Brenner: My Life in Science.

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Symmetry Breaking in Biology

Edited By Rong Li, The Stowers Institute for Medical Research; Bruce Bowerman, Institute of Molecular Biology and Department of Biology, University of Oregon

Symmetry breaking events are critical for the survival of living systems. They are required for cell division, development, and movement in all organisms from single-celled species to human beings. Moreover, in multicellular organisms, symmetry breaking allows the generation of cells with different fates and underpins the complex arrangement of tissues and organs achieved during embryogenesis.

Written and edited by experts in the field, this volume explores how symmetry breaking occurs in biology and the roles of these events at numerous different levels. The contributors examine the mechanisms by which cells polarize, divide asymmetrically, and produce asymmetric structures, providing examples from bacteria, yeast, plants, invertebrates, and mammals.

Including discussions of the molecular basis of polarization mechanisms, asymmetric division of stem cells during development, the generation of left-right asymmetry of the body axis in mammals, and theoretical approaches to symmetry breaking, the volume is a vital reference for molecular, cell, and developmental biologists, as well as physical scientists interested in how and why symmetry breaking occurs in living systems.

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The Synapse

Edited By Morgan Sheng, Genentech, Department of Neuroscience; Bernardo Sabatini, Harvard Medical School; Thomas C. Südhof, Stanford University School of Medicine

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Telomeres, Second Edition
(Cold Spring Harbor Monograph Series 45)

Edited By Titia de Lange, The Rockefeller University; Vicki Lundblad, The Salk Institute for Biological Sciences; Elizabeth Blackburn, University of California, San Francisco

An up–to–date survey of the current exciting state of telomere biology. Telomeres—specialized structures found at the ends of chromosomes— are essential for maintaining the integrity of chromosomes and their faithful duplication during cell division. Chapters in this volume cover telomere structure and function in a range of organisms, focusing on how they are maintained, their roles in cell division and gene expression, and how deficiencies in these structures contribute to cancers and other diseases and even aging.

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The TGF-β Family
(Cold Spring Harbor Monograph Series 50)

Edited By Rik Derynck, University of California, San Francisco; Kohei Miyazono, University of Tokyo

TGF-β is the prototype of a protein superfamily which, in humans, contains at least 35 members, including activins, inhibins, bone morphogenetic proteins, growth/differentiation factors, and Müllerian inhibiting substance. This monograph draws on the world’s leading laboratories to comprehensively cover all aspects of the biology of TGF-β and serve as a reference work for both specialists and researchers less familiar with the field.

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The Cardiovascular System
(Cold Spring Harbor Symposia on Quantitative Biology LXVII)

Normal cardiovascular function requires the concerted action of many cell types, each capable of adaptive gene expression in response to developmental, physiological, and pathological cues. The genetic basis of cardiovascular function, development, and disease is an area of intense investigation, in the hope of significant insights into the heart and vessels? basic workings and improvements in diagnosis and therapy. This latest volume in a prestigious book series presents a remarkable survey of current progress in these efforts, through the contributions of over fifty of the world's leading investigators. Sections are devoted to angiogenesis, cardiogenesis, homeostasis, development, vascular biology, and cardiovascular repair and therapy. The book is an essential source of ideas, discoveries, and references for clinical scientists and physicians interested in basic cardiac biology, hypertension, atherosclerosis, coronary artery disease, and heart failure.

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The Dog and Its Genome
(Cold Spring Harbor Monograph Series 44)

Edited By Elaine A. Ostrander, National Human Genome Research Institute, NIH; Urs Giger, School of Veterinary Medicine, University of Pennsylvania, Philadelphia; Kerstin Lindblad-Toh, Broad Institute of MIT and Harvard

Dogs of different breeds can range remarkably in size, shape, and behavior, and yet they all carry essentially the same genome, making them a particularly fascinating model for genome plasticity. The recent release of the complete sequence of the dog genome provides an exciting new context in which to consider such variation. Twenty–five chapters written by experts in the field include various aspects of morphological and behavioral variation in dogs, their origins and domestication, and their unique value as a model system for many common but complex human diseases such as diabetes and cancer.

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The Genome of Homo sapiens
(Cold Spring Harbor Symposia on Quantitative Biology LXVIII)

By Bruce Stillman, Cold Spring Harbor Laboratory; David Stewart, Cold Spring Harbor Laboratory

© 2003 • 544 pp., illus., appendices, index
(Hardcover edition includes online access; call for information and registration)
Hardcover • ~~$310~~ $62.00 • ISBN 978-087969709-9

The Human Genome Project was completed in 2003, 50 years after the discovery of the structure of DNA and 17 years after an influential debate at the annual Cold Spring Harbor Laboratory Symposium about the Project’s feasibility. The 2003 Symposium was dedicated to examining what has been learned so far from the human genome sequence. This book contains over sixty contributions from the world’s leaders in this field and covers genome structure and evolution, methods of data analysis, lessons from species comparison, and the application of sequence data to the understanding of disease.

Purchasers of the hard cover edition of this book are entitled to access to the Symposia website at www.cshl-symposium.org. The site contains the full text of the written communications from the 2003 Symposium and the Symposia held in 1998 through 2002 (Volumes LXIII–LXVII). Subscribers to the site also gain access to archive photographs and selected papers from the 60–year history of the Annual Symposium.

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The Genome of Homo sapiens
(Cold Spring Harbor Symposia on Quantitative Biology LXVIII)

By Bruce Stillman, Cold Spring Harbor Laboratory; David Stewart, Cold Spring Harbor Laboratory

© 2003 • 544 pp., illus., appendices, index
(Paperback edition does not include online access)
Paperback • ~~$126~~ $25.20 • ISBN 978-087969710-5

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The Molecular Gaze: Art in the Genetic Age

By Suzanne Anker, School of Visual Arts, New York; Dorothy Nelkin, New York University

The gene has become a cultural icon and an increasingly rich source of imagery and ideas for visual artists. Drawing on a wide range of contemporary painting and sculpture, The Molecular Gaze: Art in the Genetic Age explores the moral and bioethical questions these works address. What does it mean to be human? What is “identity” in a society of genetically manipulated individuals? Questions like these are growing louder as genetic technology advances and the public examines the ethical consequences more widely. Suzanne Anker and Dorothy Nelkin, an artist and a social scientist, have written a thought–provoking and visually fascinating book for scientists, artists, students, and general readers intrigued by the anxiety and exhilaration of the genetic age.

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The Unfit: A History of a Bad Idea

By Elof Axel Carlson, Professor Emeritus, State University of New York at Stony Brook

© 2001 • 451 pp., illus., bibliography, indexes
Book of the Year for 2001 in Amazon's Professional Science Category!
Hardcover • ~~$26~~ $6.50 • ISBN 978-087969587-3

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Times of Triumph, Times of Doubt: Science and the Battle for Public Trust

By Elof Axel Carlson, Professor Emeritus, State University of New York at Stony Brook

The intent and uses of science are a continuing preoccupation, especially in public debates on issues such as new pharmaceuticals, cloning, stem cells, genetically modified foods, and assisted reproduction. Times of Triumph, Times of Doubt, written by the eminent geneticist and historian Elof Carlson, explores the moral foundations of science and their role in these hot–button issues. Carlson chooses a variety of case histories and describes their scientific background and the part played by scientists in the application of their work, including their motivations and reactions to bad outcomes, both real and alleged. He examines why ethical lapses have occurred in these areas, why bad things happen when, for the most part, those who worked on the science had only good intentions in mind, and how such lapses can be prevented from occurring in the future. This exploration of ethics and science is important reading for those interested in issues of science and society, including journalists, theologians, legislators, lawyers, and scientists themselves.

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Transcriptional Regulation in Eukaryotes: Concepts, Strategies, and Techniques, Second Edition

By Michael F. Carey, University of California, Los Angeles; Craig L. Peterson, University of Massachusetts Medical School, Worcester; Stephen T. Smale, University of California, Los Angeles

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Translational Control in Biology and Medicine
(Cold Spring Harbor Monograph Series 48)

Edited By Michael B. Mathews, UMDNJ-New Jersey Medical School, Newark, New Jersey; Nahum Sonenberg, McGill University, Montreal, Canada; John W.B. Hershey, University of California, Davis

The new edition of this successful monograph has been both updated and broadened. Since the previous (second) edition was published in 2000, the structures of the bacterial and eukaryotic ribosomes have been published, advancing our basic understanding of translation and mechanisms involving protein and RNA regulators. In addition, as the title indicates, this edition has a new focus on the role of translational control in human development and disease. This book, with 30 chapters written by experts in the field, is essential reading for anyone interested in the process of translation, its regulation, and how its failure can be the cause of disease.

View two different sets of sample pages from the book here — and here —

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Type 1 Diabetes

Edited By Jeffrey A. Bluestone, University of California at San Francisco; Mark A. Atkinson, University of Florida, College of Medicine; Peter R. Arvan, University of Michigan Health System

Type 1 diabetes, also known as juvenile-onset or insulin-dependent diabetes mellitus (IDDM), is caused by destruction of insulin-producing β cells in the pancreas by the body’s immune system. It affects hundreds of thousands of individuals worldwide, requiring regular insulin injections to control blood glucose levels and avoid severe consequences of glucose dysregulation. Written by experts in the field, this book provides a detailed examination of our understanding of the disease process and its causes, as well as genetic risk factors, animal models of diabetes, and new treatment strategies that are being developed.

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Untangling the Double Helix
DNA Entanglement and the Action of the DNA Topoisomerases

By James C. Wang, Harvard University

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Untangling the Double Helix
DNA Entanglement and the Action of the DNA Topoisomerases

By James C. Wang, Harvard University

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We Can Sleep Later: Alfred D. Hershey and the Origins of Molecular Biology

Edited By Franklin W. Stahl, University of Oregon, Eugene

An absorbing portrait of the pioneering molecular biologist best known for demonstrating that DNA is the genetic component of phages, through essays and reminiscences from twenty–three distinguished scientists whose work and careers were influenced by the man and his science.

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What a Time I Am Having: Selected Letters of Max Perutz

Edited By Vivien Perutz

Selected by his daughter, Vivien, from Max Perutz’s voluminous correspondence, the letters reproduced here portray their author with a spontaneity and directness no autobiography could have matched. They chronicle Perutz’s adventurous life through his own vivid, erudite and humorous pen, documenting the hopes, roadblocks and moments of elation of his sixty-year quest to understand the molecular biology of hemoglobin. The first great step in this quest — unraveling the molecular structure of hemoglobin — earned Perutz the 1962 Nobel Prize in Chemistry. Narrated against a backdrop of family and friends, politics and war, literature, travels, and Max’s beloved mountains, these letters provide rare insight into the thoughts of a remarkable and very human scientist, and delightful sketches of some of the people he encountered. Starting with lively letters to a girlfriend written in his youth in Vienna and the impressions of a young scientist in Cambridge, the letters progress to the desperate pleas of an “enemy alien” interned in Canada during World War II. The diary of Perutz’s subsequent super-secret war work for the British to build a floating ice airstrip in the North Atlantic, ardent campaigning letters to scientists and politicians, and self-deprecating stories of his own mishaps written to amuse his children and grandchildren are some of the many highlights of these fascinating letters, unique in the annals of recent scientific history. This book is a companion to Georgina Ferry’s Max Perutz and the Secret of Life. Together these volumes provide a portrait of an extraordinary character in the development of molecular biology.

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Wnt Signaling

Edited By Roel Nusse, Stanford University Medical Center; Xi He, Children’s Hospital Boston; Renée van Amerongen, Stanford University Medical Center

Wnt proteins are signaling molecules that play critical roles during embryonic development and in the regeneration of adult tissues. They bind to Frizzled and LRP family receptors on the cell surface, triggering a series of events that cause β-catenin to enter the nucleus and activate transcription factors that control cell fate and cell proliferation. Mutations in components of the Wnt pathway lead to developmental defects and are common in cancer.

Written and edited by experts in the field, this collection from Cold Spring Harbor Perspectives in Biology covers all aspects of canonical Wnt signaling, as well as β-catenin-independent Wnt signaling and cross-talk with other pathways. The contributors examine the numerous Wnt ligands; their production, secretion, and interactions with components of the extracellular environment; and details of the downstream signaling pathways that mediate the effects of Wnt proteins on cells. The roles of Wnt signaling in stem cell self-renewal, cell polarity, body-axis specification, wound healing, and other aspects of normal development and physiology are also covered.

This volume includes discussion of Wnt signaling in cancer, skeletal defects, neurological disorders, and other human disease states. Thus, it is an indispensable reference for cell and developmental biologists as well as those, especially in the fields of stem cell biology and regenerative medicine, who are interested in targeting the Wnt pathway for therapeutic purposes.

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Won for All: How the Drosophila Genome Was Sequenced

By Michael Ashburner

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The Writing Life of James D. Watson

By Errol C. Friedberg, University of Texas Southwestern Medical Center

James Watson's fame as a scientist and research leader overshadows his considerable achievements as an innovator in the form and style of scientific communication. This book surveys Watson's books and essays from the perennially best–selling The Double Helix through his classic textbooks of the 1960s and 70s, polemics on ethical questions about genetic technology, to more recent works of autobiography.

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Yeast Intermediary Metabolism

By Dan G. Fraenkel, Harvard Medical School

The intermediary metabolism of small molecules is the meat and potatoes of cell function. The pathways and modes of obtaining energy, degradation and utilization of exogenous organic nutrients, and formation of the building blocks of the main macromolecules were a major focus of research in biology from the turn of the 20th century into the 1970s. Other matters have come to prominence, but the field is active, with interesting problems that are central to biology and medicine. Molecular biology developed through the use of one bacterium, Eschericha coli, with the saying “What’s true for E. coli is true for elephants.” In recent years, an analogous workhorse has been the eukaryotic microbe baker’s yeast, Saccharomyces cerevisiae, used in many studies of cell biology common to multicellular organisms. This book explains metabolism as based on Saccharomyces. The topics include central metabolic pathways; catabolism; fermentation; respiration; biosynthesis of small molecules including cofactors; the metabolism of lipids, polysaccharides, and storage molecules; inorganic ions; transport and compartments; the global analysis of metabolism; and issues of metabolic toxicity. It can be used in courses and as a reference book for research investigators.

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