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Cell Survival and Cell Death

Edited By Eric H. Baehrecke, University of Massachusetts; Douglas R. Green, St. Jude Children's Research Hospital; Sally Kornbluth, Duke University; Guy S. Salvesen, Sanford-Burnham Medical Research Institute

Due August 2013 • 300 pp. (approx.), illus. (29 4C, 51 B&W), index
Hardcover • $135 • ISBN 978-1-936113-31-6

Cell death plays a critical role in development, normal physiology, and many diseases, including cancer. This short book describes our detailed understanding of the mechanisms involved in cell death signaling, covering signal transducers, caspases, Bcl2-family proteins, mitochondrial molecules, and IAPs, as well as the survival mechanisms that antagonize them. Cell death mechanisms involved in tumor suppression and cancer are also covered.

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Mitochondria

Edited By Douglas C. Wallace, Children's Hospital of Philadelphia, University of Pennsylvania; Richard J. Youle, National Institute of Neurological Disorders and Strokes, Porter Neuroscience Research Center

Due September 2013 • 300 pp.(approx.), illus., index
Hardcover • $135 • ISBN 978-1-936113-35-4

Mitochondria are intracellular organelles that power the cell by metabolizing glucose and other energy sources to generate ATP. They are also critical in programmed cell death, and dysfunction of mitochondrial components is implicated in numerous muscle and neurodegenerative disorders, including Parkinson’s disease. This volume contains contributions examining the evolution and normal function of mitochondria in cells, as well as their roles in various pathologies.

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Mammalian Development: Networks, Switches, and Morphogenetic Processes

Edited By Patrick P.L. Tam, Children’s Medical Research Institute; W. James Nelson, Stanford University; Janet Rossant, The Hospital for Sick Children

© 2013 • 520 pp., illus. (120 4C, 21 B&W), index
Hardcover • $155 • ISBN 978-1-936113-24-8

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DNA Replication

Edited By Stephen D. Bell, Indiana University, Bloomington; Marcel Méchali, Institute of Human Genetics, CNRS, Montpellier; Melvin L. DePamphilis, National Institutes of Health, Bethesda

© 2013 • 576 pp., illus. (88 4C, 33 B&W), appendices, index
Hardcover • $135 • ISBN 978-1-936113-48-4

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Introduction to Protein-DNA Interactions: Structure, Thermodynamics, and Bioinformatics

By Gary D. Stormo, Ph.D.

© 2013 • 208 pp., illus. (78 4C, 5 B&W), index
Paperback • $45 • ISBN 978-1-936113-50-7

One of the foundations of molecular biology is how the interactions of proteins with DNA control many aspects of gene expression. Since the mid-20th century, from discoveries of the lac repressor and operator and the competition between the cI and cro proteins for the same segment of DNA, we have learned an enormous amount about the interactions of proteins with DNA and their control of fundamental processes in the cell. Introduction to Protein–DNA Interactions: Structure, Thermodynamics, and Bioinformatics describes what we know about protein–DNA interactions from the complementary perspectives of molecular and structural biology and bioinformatics and how each perspective informs the others. A particular emphasis is on how insights from experimental work can be translated into specific computational approaches to create a unified view of the field and a fuller understanding of protein–DNA interactions.

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Introduction to Protein-DNA Interactions: Structure, Thermodynamics, and Bioinformatics

By Gary D. Stormo, Ph.D.

© 2013 • 208 pp., illus. (78 4C, 5 B&W), index
Hardcover • $79 • ISBN 978-1-936113-49-1

One of the foundations of molecular biology is how the interactions of proteins with DNA control many aspects of gene expression. Since the mid-20th century, from discoveries of the lac repressor and operator and the competition between the cI and cro proteins for the same segment of DNA, we have learned an enormous amount about the interactions of proteins with DNA and their control of fundamental processes in the cell. Introduction to Protein–DNA Interactions: Structure, Thermodynamics, and Bioinformatics describes what we know about protein–DNA interactions from the complementary perspectives of molecular and structural biology and bioinformatics and how each perspective informs the others. A particular emphasis is on how insights from experimental work can be translated into specific computational approaches to create a unified view of the field and a fuller understanding of protein–DNA interactions.

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Next-Generation DNA Sequencing Informatics

Edited By Stuart M. Brown, New York University School of Medicine

© 2013 • 241 pp., illus. (48 4C & 15 B&W), index
Hardcover • $59 • ISBN 978-1-936113-87-3

Next-generation DNA sequencing (NGS) technology has revolutionized biomedical research, making complete genome sequencing an affordable and frequently used tool for a wide variety of research applications. Bioinformatics methods to support DNA sequencing have become a critical bottleneck for many researchers and organizations wishing to make use of NGS technology. This book provides a thorough introduction to the necessary informatics methods and tools for operating NGS instruments and analyzing NGS data. The book also provides extensive reference to best-practice bioinformatic methods for the most commonly used NGS technologies and applications. The book also includes reference to, and guidance on, the setup and use of essential software for NGS data analysis. This is the first book of its kind to address the informatics needs of scientists who wish to take advantage of the explosion of research opportunities offered by new DNA sequencing technologies.

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Genome Science: A Practical and Conceptual Introduction to Molecular Genetic Analysis in Eukaryotes

By David Micklos, Cold Spring Harbor Laboratory; Bruce Nash, Cold Spring Harbor Laboratory; Uwe Hilgert, University of Arizona

© 2013 • 704 pp., illus (3 4C, 606 B&W), index
Hardcover • $55 • ISBN 978-0-879698-59-1

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Protein Synthesis and Translational Control

Edited By John W.B. Hershey, University of California, Davis; Nahum Sonenberg, McGill University; Michael B. Mathews, New Jersey Medical School, University of Medicine and Dentistry of New Jersey

© 2012 • 352 pp., illustrations, index
Hardcover • $135 • ISBN 978-1-936113-46-0

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Molecular Cloning: A Laboratory Manual
(Fourth Edition)

By Michael R. Green, Howard Hughes Medical Institute, University of Massachusetts Medical School; Joseph Sambrook, Peter MacCallum Cancer Institute, Melbourne, Australia

© 2012 • 2,028 pp., illus., appendices, index
Paperback (three-volume set) • $365 $255.50 • ISBN 978-1-936113-42-2