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An Introduction to Nervous Systems

By Ralph J. Greenspan, The Neurosciences Institute, San Diego, California

© 2007 • 172 pp., illus., bibliography, glossary, index
Hardcover • $67.00 $33.50 • ISBN 978-087969757-0

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Experimental Design for Biologists

By David J. Glass, M.D., Novartis Institutes for Biomedical Research, Cambridge, Massachusetts

© 2007 • 206 pp., illus., index
Hardcover • $37.00 $25.90 • ISBN 978-087969735-8

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Cell Biology of Addiction

Edited By Bertha K. Madras, Harvard Medical School; Christine M. Colvis, National Institute on Drug Abuse/NIH; Jonathan D. Pollock, National Institute on Drug Abuse/NIH; Joni L. Rutter, National Institute on Drug Abuse/NIH; David Shurtleff, National Institute on Drug Abuse/NIH; Mark von Zastrow, University of California, San Francisco

© 2006 • 465 pp., illus., appendices, index
Hardcover • $129 $32.25 • ISBN 978-087969753-2

This monograph, written by experts in the field, is devoted to the molecular analysis of addiction pathways in the brain. It provides an intensive overview of the fundamentals, state–of–the–art advances, and major gaps in the cell and molecular biology of drug addiction within the broader context of neuroscience. Addiction research is a branch of neuroscience and psychology. The emphasis in this book is on hard science and the market for it will be found among research investigators and grad students within the field of neuroscience. The research presented is not only applicable to the study of drug abuse and addiction, but has clear implications for clarifying mechanisms of learning and memory, neuroadaptation, perception, volitional behavior, motivation, reward, and other disciplines of neuroscience.

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Basic Methods in Microscopy
Protocols and Concepts from Cells: A Laboratory Manual

By David L. Spector, Cold Spring Harbor Laboratory; Robert D. Goldman, Northwestern University Medical School, Chicago

© 2006 • 382 pp., illus., index
Paperback • $97.00 • ISBN 978-087969751-8

Imaging has become a vital tool for researchers in all aspects of biology. Recent advances in microscope technology, labeling techniques and gene and protein manipulation methods have led to breakthroughs in our understanding of biological processes. In order to take advantage of these techniques, biologists need to understand the fundamental techniques of microscopy. The methods found here, drawn from the popular laboratory standard manual Cells: A Laboratory Manual, provide a solid course in the basics of using the microscope in a biology laboratory.

Basic Methods in Microscopy provides an essential guide to light microscopy, fluorescence microscopy, confocal microscopy, multiphoton microscopy and electron microscopy, preparation of tissues and cells, labeling of specimens and analysis of cellular events.

This manual is an important tool for any biology researcher employing imaging as a research method.

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Prion Biology and Diseases, Second Edition
(Cold Spring Harbor Monograph Series 41)

Edited By Stanley B. Prusiner, University of California, San Francisco

© 2004 • 1,050 pp., illus., color plates, glossary, appendix, index
Hardcover • $147 $29.40 • ISBN 978-087969693-1

This volume is a new edition of the most authoritative book on Prion Biology, first published in 1999 and edited by the Nobel Prize–winning founder of the field. This expanded edition has been completely updated, and includes chapters on therapeutics, and diagnostic methods and approaches.

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RNAi: A Guide to Gene Silencing

Edited By Gregory J. Hannon, Cold Spring Harbor Laboratory

© 2003 • 436 pp., illus., index
Paperback • $75 $15.00 • ISBN 978-087969704-4

The ability of double stranded RNA to inhibit the expression of genes with an appropriate sequence can be harnessed to silence target genes in vitro in a new and powerful way. This volume combines reliable RNAi protocols for a variety of species with discussion of strategies for the effective design of experiments using this important new technique that is changing the way experimental science is done.

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RNAi: A Guide to Gene Silencing

Edited By Gregory J. Hannon, Cold Spring Harbor Laboratory

© 2003 • 436 pp., illus., index
Printed hardcover • $130 $26.00 • ISBN 978-087969641-2

The ability of double stranded RNA to inhibit the expression of genes with an appropriate sequence can be harnessed to silence target genes in vitro in a new and powerful way. This volume combines reliable RNAi protocols for a variety of species with discussion of strategies for the effective design of experiments using this important new technique that is changing the way experimental science is done.

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Neurobiology of the Leech

Edited By Kenneth J. Muller, Carnegie Institution of Washington; John G. Nicholls, Stanford University School of Medicine; Gunther S. Stent, University of California, Berkeley

© 1981 • 320 pp., illus., bibliography, indexes
Paperback • $123.00 • ISBN 978-193611309-5

In the 19th century, the medicinal applications of leeches prompted basic research into their neurobiology, reproduction, development, and anatomy; subsequently, leeches became an important model for understanding the nervous system. In this monograph, each chapter provides a narrative account of experimental work on a particular area of leech neurobiology, and explains its significance for the broader field of neuroscience. The appendices describe methods for maintaining and manipulating leeches in the laboratory and include an atlas of neurons in the leech Hirudo medicinalis. Extensively illustrated, this book is a classic in the field and is considered a “must read” for neuroscientists and those interested in leech biology. It has been out of print for many years; however, some recent inquiries have prompted us to reprint it and make it available at an affordable price.